Results 31 to 40 of about 40,327 (214)

Long-Term Clinical and Ecological Impact of an Antimicrobial Stewardship Program on the Incidence of Carbapenem-Resistant Klebsiella pneumoniae Infections in a High-Endemic Hospital

Antibiotics
Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) is currently a serious global concern. Antimicrobial stewardship programs (ASPs) are one of the key strategies to overcome this resistance.
Teresa López-Viñau, Montserrat Muñoz-Rosa, Lidia Mª Ruiz-Lara, Lucrecia García-Martínez, Isabel Machuca, Irene Gracia-Ahufinger, Rafael Ruiz Montero, Juan José Castón, Ángela Cano, Elisa Ruiz-Arabi, José Ramón del Prado, Inmaculada Salcedo, Luis Martínez-Martínez, Julián Torre-Cisneros   +13 more
doaj   +1 more source

Synergistic Inhibition of MRSA by Chenodeoxycholic Acid and Carbapenem Antibiotics

Antibiotics, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) has posed a severe global health threat. In this study, we screened an antibiotic and non-antibiotic combination that provides a viable strategy to solve this issue by broadening the antimicrobial ...
Kaiyu Cui, Weifeng Yang, Shuang Liu, Dongying Li, Lu Li, Xing Ren, Yanan Sun, Gaiying He, Shuhua Ma, Jidan Zhang, Qing Wei, Yi Wang   +11 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Breaking Through Resistance: Carbapenem-Resistant Nocardia?!—A Case Report

Medicina
Nocardia is an emerging bacterial disease that often affects patients with compromised immune systems. As the number of patients undergoing solid organ transplants continues to rise, and as more cancer survivors are treated with long-term immune ...
Vlad-Sabin Ivan, Paul-Gabriel Ciubotaru, Liviu Cirin, Florin Giru, Dan Costachescu, Daniel-Florin Lighezan, Roxana Buzas   +6 more
doaj   +1 more source

Carbapenem-Nonsusceptible Acinetobacter baumannii, 8 US Metropolitan Areas, 2012–2015

Emerging Infectious Diseases, 2018
In healthcare settings, Acinetobacter spp. bacteria commonly demonstrate antimicrobial resistance, making them a major treatment challenge. Nearly half of Acinetobacter organisms from clinical cultures in the United States are nonsusceptible to ...
Sandra N. Bulens, Sarah H. Yi, Maroya S. Walters, Jesse T. Jacob, Chris Bower, Jessica Reno, Lucy Wilson, Elisabeth Vaeth, Wendy Bamberg, Sarah J. Janelle, Ruth Lynfield, Paula Snippes Vagnone, Kristin Shaw, Marion Kainer, Daniel Muleta, Jacqueline Mounsey, Ghinwa Dumyati, Cathleen Concannon, Zintars Beldavs, P. Maureen Cassidy, Erin C. Phipps, Nicole Kenslow, Emily B. Hancock, Alexander J. Kallen   +23 more
doaj   +1 more source

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings

British Journal of Clinical Pharmacology, EarlyView.
Abstract Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these objectives.
Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala   +3 more
wiley   +1 more source

Carbapenem-Resistant Gram-Negative Bacterial Infections at a Tertiary Health Care Center in Nepal: An Observational Study

Journal of Nepal Medical Association
Introduction: Carbapenems are last-resort antibiotics and are considered the drugs of choice for infections caused by multi-drug-resistant bacteria. During the last several years, there has been an alarming global increase in the detection and spread of
Dimpi Konwar, Navin Kumar Chaudhary, Poonam Yadav   +2 more
doaj   +1 more source

Iron Acquisition and Siderophore Release by Carbapenem-Resistant Sequence Type 258 Klebsiella pneumoniae

mSphere, 2018
Klebsiella pneumoniae is rapidly acquiring resistance to all known antibiotics, including carbapenems. Multilocus sequence type ST258 (sequence type 258), carrying a gene encoding the K.
Victoria I. Holden, Meredith S. Wright, Sébastien Houle, Abigail Collingwood, Charles M. Dozois, Mark D. Adams, Michael A. Bachman   +6 more
doaj   +1 more source

Relationship between continuous infusion meropenem PK/PD target attainment and C‐reactive protein dynamics in onco‐haematologic patients with febrile neutropenia

British Journal of Clinical Pharmacology, EarlyView.
Aim Meropenem is a second‐line antimicrobial agent in the treatment of febrile neutropenia in onco‐haematological patients. A population pharmacokinetic/pharmacodynamic (PK/PD) analysis for assessing the relationship between meropenem exposure and C‐reactive protein (C‐RP) over time was conducted.
Chun Liu, Pier Giorgio Cojutti, J. G. Coen van Hasselt, Michele Bartoletti, Maddalena Giannella, Pierluigi Zinzani, Pierluigi Viale, Federico Pea   +7 more
wiley   +1 more source

Nocardiosis in Renal Allograft Recipients

Journal of Global Infectious Diseases
Introduction: The aim of the study was to study the clinical profile and outcomes of nocardiosis in renal allograft recipients. Methods: This was a retrospective study of clinical outcomes in consecutive renal allograft recipients with Nocardia infection
Chilaka Rajesh, Athul Thomas, Jeethu Joseph Eapen, Sabina Yusuf, Elenjickal Elias John, Anna T. Valson, Suceena Alexander, Vinoi George David, Joy Sarojini Michael, Santosh Varughese   +9 more
doaj   +1 more source