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The development of antibiotics remains one of the great advances in medicine. Antibiotics have saved countless lives. Unfortunately, the widespread use of antimicrobials has led to the development of antimicrobial resistance.
David Sotello +2 more
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Carbapenems in clinical practice
Increasing frequency of infections caused by multi-drug resistant organisms is currently observed in the adult and pediatric population. It is the clinician’s responsibility to use wide-spectrum antibiotics when appropriate, where such a potent treatment
S.O. Kramarov, V.V. Yevtushenko
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Introduction: The contribution of efflux systems to drug resistance in Enterobacteriaceae is becoming increasingly appreciated. This study phenotypically analyzed the role of efflux mechanisms in resistance to ertapenem, doripenem, and tigecycline among ...
Joel Filgona +2 more
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Among the many different structurally distinct classes of beta-lactams, the carbapenem class is regarded as that which is most potent and which has the widest spectrum of antimicrobial activity. Rapidly bactericidal, and demonstrating time-dependent killing, carbapenemes have a spectrum of antimicrobial activity that includes Gram-positive and Gram ...
openaire +2 more sources
Risk factors for hospital infections caused by carbapanem-resistant Acinetobacter baumannii
Introduction: Acinetobacter baumannii is one of major causative agents of severe, life-threatening hospital infections (HIs), especially in intensive care units (ICUs).
Zorana M Djordjevic +5 more
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In clinical settings, rapid and accurate diagnosis of antibiotic resistance is essential for the efficient treatment of bacterial infections. Conventional methods for antibiotic resistance testing are time consuming, while molecular methods such as PCR ...
Wei Liu +9 more
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This item has no abstract. Use the links below to access the full text.
Atul Khajuria +3 more
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Relevance: The two systems for determining the susceptibility of bacteria to antimicrobial drugs, CLSI and EUCAST, are recommended for use in the global system of epidemiological surveillance of antimicrobial resistance of the World Health Organization ...
L. A. Kornoukhova +3 more
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A new carbapenem antibiotic — biapenem — previously used only in Japan and Southeast Asia, was registered in Russia in 2021. The article analyzes the antimicrobial, pharmacokinetic, and clinical characteristics of biapenem in detail, provides ...
S. V. YAKOVLEV, M. P. SUVOROVA
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Since the end of 2019, the Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, affecting people worldwide.
Corneliu Ovidiu Vrancianu +6 more
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