Carbazole Derivatives as Potential Antimicrobial Agents [PDF]
Molecules, 2022 Microbial infection is a leading cause of death worldwide, resulting in around 1.2 million deaths annually. Due to this, medicinal chemists are continuously searching for new or improved alternatives to combat microbial infections.
Siddappa A. Patil +5 more
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Carbazole Derivatives as Antiviral Agents: An Overview [PDF]
Molecules, 2019 Viruses represent the most common cause of infectious diseases worldwide and those with rapid propagation and high infection rates cause human and animal pandemics. These fast-spreading diseases are generally treated with antiviral drugs but, often, drug
Anna Caruso +7 more
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Antiviral Activities of Carbazole Derivatives against Porcine Epidemic Diarrhea Virus In Vitro [PDF]
Viruses, 2021 Porcine epidemic diarrhea virus (PEDV), an enteric coronavirus, causes neonatal pig acute gastrointestinal infection with a characterization of severe diarrhea, vomiting, high morbidity, and high mortality, resulting in tremendous damages to the swine ...
Zheng Chen +11 more
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Design, synthesis, molecular docking and biological evaluation of new carbazole derivatives as anticancer, and antioxidant agents [PDF]
BMC Chemistry, 2023 Background The carbazole skeleton is an important structural motif occurring naturally or synthesized chemically and has antihistaminic, antioxidant, antitumor, antimicrobial, and anti-inflammatory activities.
İrfan Çapan +5 more
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Preparation and property analysis of antioxidant of carbazole derivatives [PDF]
BMC Chemistry, 2023 Carbazole derivatives can be used as antioxidants in the lubricating oil industry. The alkylation of carbazole with 2-chloro-2-methylpropane and 2-bromopropane catalyzed by anhydrous aluminum chloride was studied.
Zhi-quan Zhang +3 more
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Carbazole Derivatives’ Binding to c-KIT G-Quadruplex DNA [PDF]
Molecules, 2018 The binding affinities of three carbazole derivatives to the intramolecular G-quadruplex (GQ) DNA formed by the sequence 5′-AGGGAGGGCGCTGGGAGGAGGG-3′, derived from the c-KIT 1 oncogene region, were investigated. All carbazole cationic ligands
Agata Głuszyńska +4 more
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Carbazole Derivatives as STAT Inhibitors: An Overview [PDF]
Applied Sciences, 2021 The carbazole class is made up of heterocyclically structured compounds first isolated from coal tar. Their structural motif is preponderant in different synthetic materials and naturally occurring alkaloids extracted from the taxonomically related ...
Anna Caruso +5 more
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Structural diversity-guided optimization of carbazole derivatives as potential cytotoxic agents [PDF]
Frontiers in Chemistry, 2023 Carbazole alkaloids, as an important class of natural products, have been widely reported to have extensive biological activities. Based on our previous three-component reaction to construct carbazole scaffolds, we introduced a methylene group to provide
Zilin Gao +6 more
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Palindromic carbazole derivatives: unveiling their antiproliferative effect via topoisomerase II catalytic inhibition and apoptosis induction [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryHuman DNA topoisomerases are essential for crucial cellular processes, including DNA replication, transcription, chromatin condensation, and maintenance of its structure.
Mateusz Olszewski +8 more
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Repurposing anti-inflammatory drugs for fighting planktonic and biofilm growth. New carbazole derivatives based on the NSAID carprofen: synthesis, in silico and in vitro bioevaluation [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionOne of the promising leads for the rapid discovery of alternative antimicrobial agents is to repurpose other drugs, such as nonsteroidal anti-inflammatory agents (NSAIDs) for fighting bacterial infections and antimicrobial resistance.MethodsA
Florea Dumitrascu +14 more
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