Results 111 to 120 of about 187,315 (266)

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Sugar conformations that enhance cleavage of glycosidic bonds in carbohydrate-active enzymes [PDF]

, 2015
Carbohydrate-active enzymes select particular conformations of one sugar of their carbohydrate substrates to enhance catalysis. The evolution of this conformation during catalysis, known as the catalytic itinerary, is of fundamental interest in ...
Raich, Lluís, Rovira, Carme
core   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Discovery and industrial application of lytic polysaccharide mono-oxygenases

, 2015
The recent discovery of the copper dependent lytic polysaccharide monooxygenases (LPMOs) has opened the door to a vast area of research within several fields.
Salomon Johansen, Katja,
core  

Climate Change Threatens Micronutrient Density of European Winter Wheat

Advanced Science, EarlyView.
Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao, Jennifer Michel, Eline Lorer, Markus Weinmann, Jacques Le Gouis, Claire Léon, Sibille Perrochon, David Alvarez, Vincent Leemans, Iñaki Balanzategui Guijarro, Jordi Moya Laraño, Sara Sánchez Moreno, Symanczik Sarah, Waibel Matthias, Hervé Vanderschuren, Cécile Thonar, Pierre Delaplace, Dominique Van Der Straeten   +17 more
wiley   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Carbohydrate-active enzymes involved in rice cell wall metabolism

Plant cell walls are complex, multifunctional structures, built up of polysaccharides and proteins. The configuration and abundance of cell wall constituents determine cellular elongation and plant growth. The emphasis of this review is on rice, a staple
Van Damme, ElsLA25LA51LA55LA59LA62LA638010016464310000-0001-9848-766XF67A8F2E-F0ED-11E1-A9DE-61C894A0A6B4, Desmet, TomLA250019944645878010015014360000-0002-5788-3022F61853C2-F0ED-11E1-A9DE-61C894A0A6B4, De Coninck, TiboLA250001502087428020032103320000-0003-1600-26796D74B094-2298-11E5-B7DC-237BB5D1D7B1   +2 more
core   +2 more sources

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Carbohydrate bioengineering : proceedings of an international conference, Elsinore, Denmark, April 23-26, 1995 /

The Carbohydrate Bioengineering Meeting held in Elsinore, Denmark, April 23-26, 1995, gathered 230 scientists, mostly from Europe, with interest in carbohydrate analysis and structure; carbohydrates in medicine and glycopathology; structure, function ...
Petersen, Steffen B., Svensson, Birte., Pedersen, Sven., Carbohydrate Bioengineering Meeting(1995 :Helsingør, Denmark)   +3 more
core  

Carbohydrate active enzymes and ligninases in metagenome (see also File S4).

, 2013
Carbohydrate active enzymes and ligninases in metagenome (see also File S4).
Martin Allgaier (222799), John M. Gladden (162494), Patrik S. G. Chain (435193), Steven W. Singer (162486), Errol W. Robinson (328862), Joshua T. Aldrich (435194), Blake A. Simmons (108789), Philip Hugenholtz (13833), Carrie D. Nicora (230020), Ljiljana Pasa-Tolic (154807), Patrik D'haeseleer (101469), Stephanie A. Malfatti (124718), Susannah G. Tringe (43680)   +12 more
core   +1 more source