Results 31 to 40 of about 978 (138)

The Emerging Role of Carbon-Ion Radiotherapy

Frontiers in Oncology, 2016
Carbon-ion radiotherapy (CIRT) has progressed rapidly in technological delivery, indications, and efficacy. Owing to a focused dose distribution in addition to high linear energy transfer and subsequently high relative biological effect, CIRT is uniquely
Daniel K Ebner, Daniel K Ebner, Tadashi eKamada   +2 more
doaj   +1 more source

Biological Guided Carbon-Ion Microporous Radiation to Tumor Hypoxia Area Triggers Robust Abscopal Effects as Open Field Radiation

Frontiers in Oncology, 2020
Recently, a growing number of studies focus on partial tumor irradiation to induce the stronger non-target effects. However, the value of partial volume carbon ion radiotherapy (CIRT) targeting hypoxic region of a tumor under imaging guidance as well as ...
Qingting Huang, Qingting Huang, Qingting Huang, Yun Sun, Yun Sun, Weiwei Wang, Weiwei Wang, Lien-Chun Lin, Lien-Chun Lin, Yangle Huang, Jing Yang, Jing Yang, Xiaodong Wu, Xiaodong Wu, Lin Kong, Lin Kong, Jiade Jay Lu, Jiade Jay Lu   +17 more
doaj   +1 more source

Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review

Frontiers in Oncology, 2021
Adenoid cystic carcinoma (ACC) is a rare, basaloid, epithelial tumor, arising mostly from salivary glands. Radiation therapy can be employed as a single modality for unresectable tumors, in an adjuvant setting after uncomplete resection, in case of high ...
Pierre Loap, Pierre Loap, Pierre Loap, Barbara Vischioni, Maria Bonora, Rossana Ingargiola, Sara Ronchi, Viviana Vitolo, Amelia Barcellini, Lucia Goanta, Ludovic De Marzi, Ludovic De Marzi, Ludovic De Marzi, Remi Dendale, Remi Dendale, Roberto Pacelli, Laura Locati, Laura Locati, Valentin Calugaru, Valentin Calugaru, Hamid Mammar, Hamid Mammar, Stefano Cavalieri, Stefano Cavalieri, Youlia Kirova, Youlia Kirova, Ester Orlandi   +26 more
doaj   +1 more source

Secondary cancers after carbon‐ion radiotherapy and photon beam radiotherapy for uterine cervical cancer: A comparative study

Cancer Medicine, 2022
Background There are limited studies on the risk of secondary cancers after carbon‐ion radiotherapy (CIRT). We assessed the incidence of secondary cancers in patients treated with CIRT for cervical cancer.
Yuki Nitta, Hiroto Murata, Noriyuki Okonogi, Kazutoshi Murata, Masaru Wakatsuki, Kumiko Karasawa, Shingo Kato, Shigeru Yamada, Takashi Nakano, Hiroshi Tsuji   +9 more
doaj   +1 more source

Carbon ion radiotherapy boosts anti-tumour immune responses by inhibiting myeloid-derived suppressor cells in melanoma-bearing mice

Cell Death Discovery, 2021
Numerous studies have shown that carbon ion radiotherapy (CIRT) induces anti-cancer immune responses in melanoma patients, yet the mechanism remains elusive.
Heng Zhou, Pengfei Yang, Haining Li, Liying Zhang, Jin Li, Tianyi Zhang, Chengyan Sheng, Jufang Wang   +7 more
doaj   +1 more source

Carbon Ion Radiotherapy Evokes a Metabolic Reprogramming and Individualized Response in Prostate Cancer

Frontiers in Public Health, 2021
Introduction: Carbon ion radiotherapy (CIRT) is a novel treatment for prostate cancer (PCa). However, the underlying mechanism for the individualized response to CIRT is still not clear.
Renli Ning, Renli Ning, Renli Ning, Yulei Pei, Yulei Pei, Yulei Pei, Ping Li, Ping Li, Ping Li, Wei Hu, Wei Hu, Wei Hu, Yong Deng, Yong Deng, Yong Deng, Zhengshan Hong, Zhengshan Hong, Zhengshan Hong, Yun Sun, Yun Sun, Yun Sun, Qing Zhang, Qing Zhang, Qing Zhang, Xiaomao Guo, Xiaomao Guo, Xiaomao Guo   +26 more
doaj   +1 more source

Estimating the Number of Patients Eligible for Carbon Ion Radiotherapy in the United States [PDF]

International Journal of Particle Therapy, 2020
Purpose: Carbon ion radiotherapy (CIRT) is an emerging radiotherapy modality with potential advantages over conventional photon-based therapy, including exhibiting a Bragg peak and greater relative biological effectiveness, leading to a higher degree of ...
Timothy D. Malouff, MD, Laura A. Vallow, MD, Danushka Seneviratne, MD, PhD, Anita Mahajan, MD, Robert L. Foote, MD, Bradford Hoppe, MD, Chris Beltran, PhD, Steven J. Buskirk, MD, Sunil Krishnan, MBBS, MD, Daniel M. Trifiletti, MD   +9 more
doaj   +1 more source

Carbon ion radiotherapy of hepatocellular carcinoma provides excellent local control: The prospective phase I PROMETHEUS trial

JHEP Reports
Background & Aims: Inoperable hepatocellular carcinoma (HCC) can be treated by stereotactic body radiotherapy. However, carbon ion radiotherapy (CIRT) is more effective for sparing non-tumorous liver. High linear energy transfer could promote therapy
Philipp Hoegen-Saßmannshausen, Patrick Naumann, Paula Hoffmeister-Wittmann, Semi Ben Harrabi, Katharina Seidensaal, Fabian Weykamp, Thomas Mielke, Malte Ellerbrock, Daniel Habermehl, Christoph Springfeld, Michael T. Dill, Thomas Longerich, Peter Schirmacher, Arianeb Mehrabi, De-Hua Chang, Juliane Hörner-Rieber, Oliver Jäkel, Thomas Haberer, Stephanie E. Combs, Jürgen Debus, Klaus Herfarth, Jakob Liermann   +21 more
doaj   +1 more source

Mechanisms of Therapeutic Resistance and Recent Advances in Glioblastoma Treatment

Immunology &Cell Biology, Volume 104, Issue 7, Page 711-728, August 2026.
Three interconnected processes in glioblastoma (GBM) biology: initiation, stratification, and immunosuppression. 1) Initiation: GBM initiation is proposed to occur through migration of TERT mutation‐bearing neural stem cells from the subventricular zone to the frontal and temporal cortices, where a subsequent oncogenic transformation drives their ...
Emerson Achari, Farah Ahmady‐Nield, Amit Sharma, Ingo G. H. Schmidt‐Wolf, Jarek Maciaczyk, Rodney B. Luwor, Adrian A. Achuthan   +6 more
wiley   +1 more source

Preliminary exploration of clinical factors affecting acute toxicity and quality of life after carbon ion therapy for prostate cancer

Radiation Oncology, 2019
Purpose To assess toxicity and quality-of-life (QOL) after carbon ion radiotherapy (CIRT) at the Shanghai Proton and Heavy Ion Center (SPHIC) and identify clinical factors that correlate with urinary, bowel and sexual function.
Yafang Zhang, Ping Li, Qi Yu, Shuang Wu, Xue Chen, Qing Zhang, Shen Fu   +6 more
doaj   +1 more source