Results 41 to 50 of about 978 (138)

Feasibility Study of Combined Systemic Therapy and Carbon‐Ion Radiotherapy for Hepatocellular Carcinoma Patients

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background Recent advances in systemic therapy, including tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs), have improved outcomes for hepatocellular carcinoma (HCC) and enabled downstaging strategies that allow subsequent local treatments. Carbon‐ion radiotherapy (CIRT) can provide excellent tumor control with minimal
Daijiro Kobayashi, Kei Shibuya, Yuhei Miyasaka, Kenichiro Araki, Yuichi Yamazaki, Ken Shirabe, Tatsuya Ohno   +6 more
wiley   +1 more source

Efficacy and safety of carbon‐ion radiotherapy for the malignant melanoma: A systematic review

Cancer Medicine, 2020
Malignant melanomas (MMs) were the fifth most common cancer in men and the sixth most common cancer in women in 2018, respectively. These are characterized by high metastatic rates and poor prognoses.
Chengcheng Li, Qiuning Zhang, Zheng Li, Shuangwu Feng, Hongtao Luo, Ruifeng Liu, Lina Wang, Yichao Geng, Xueshan Zhao, Zhen Yang, Qiang Li, Kehu Yang, Xiaohu Wang   +12 more
doaj   +1 more source

A data analysis framework for in vivo monitoring in carbon-ion radiotherapy (CIRT): towards 3D reconstruction of interfractional anatomical changes

Physics in Medicine & Biology
Abstract Objectives. Carbon-ion radiotherapy is a cancer treatment modality with exceptional precision and effectiveness compared to conventional x-ray therapy. Our goal is to support maintaining its precise dose administration throughout a multi-fractional radiation treatment by detecting ...
Patrice Schlegel, Rebekka Kirchgaessner, Pamela Ochoa Parra, Laurent Kelleter, Michael Gertz, Ralf Mikut, Oliver Jäkel, Maria Martišíková   +7 more
openaire   +3 more sources

Feasibility of upright carbon ion radiotherapy for prostate cancer: Dosimetric comparison between supine and upright postures

Medical Physics, Volume 53, Issue 7, July 2026.
Abstract Background Carbon ion radiotherapy (CIRT) in the upright posture is a treatment technique which delivers carbon ion beams from a fixed direction to patients who sit or stand on a rotating chair. Although various potential advantages of the upright positioning have been discussed, feasibility of upright CIRT for prostate cancer has not been ...
Yusuke Nomura, Taku Inaniwa, Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Hideyuki Mizuno, Shunsuke Yonai, Yoshiyuki Iwata, Kohei Oguma, Junichi Fukada, Naoyuki Shigematsu, Atsuya Takeda, Hitoshi Ishikawa, Masahiro Jinzaki   +13 more
wiley   +1 more source

Combining radiotherapy with CAR‐T cell therapy for solid tumors: Challenges, mechanisms, and future directions

Precision Radiation Oncology, Volume 10, Issue 2, Page 192-204, June 2026.
Radiotherapy enhances CAR‐Tcell therapy by increasing antigenicity, improving trafficking, and reshaping the tumor microenvironment. Despite its dual effects, including potential immune suppression, understanding these mechanisms enables the development of strategies to maximize synergy in solid tumors.
Leran Qiu, Xingyu Zhou, Jiao Xue, Xiaokang Zhang, Songbing Qin   +4 more
wiley   +1 more source

A future directions of renal cell carcinoma treatment: combination of immune checkpoint inhibition and carbon ion radiotherapy

Frontiers in Immunology
Renal cell carcinoma (RCC) is considered radio- and chemo-resistant. Immune checkpoint inhibitors (ICIs) have demonstrated significant clinical efficacy in advanced RCC. However, the overall response rate of RCC to monotherapy remains limited.
Zhouhang Zheng, Zhouhang Zheng, Tianci Yang, Tianci Yang, Yixuan Li, Yixuan Li, Pei Qu, Pei Qu, Zhiang Shao, Zhiang Shao, Yuan Wang, Yuan Wang, Wei Chang, Shahzad Muhammad Umar, Jufang Wang, Jufang Wang, Nan Ding, Nan Ding, Wei Wang   +18 more
doaj   +1 more source

Outcomes of orbital malignancies treated with eye-sparing surgery and adjuvant particle radiotherapy: a retrospective study

BMC Cancer, 2019
Background To report the clinical experience of eye sparing surgery (ESS) and adjuvant carbon-ion or proton radiotherapy (CIRT or PRT) for orbital malignancies. Methods An analysis of the retrospective data registry from the Shanghai Proton and Heavy Ion
Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade J. Lu   +6 more
doaj   +1 more source

A new perspective on radiotherapy in the comprehensive treatment of cancer

Precision Radiation Oncology, Volume 10, Issue 2, Page 165-183, June 2026.
Radiotherapy remains a key component in the comprehensive management of cancer. Its effectiveness is significantly improved through strategic combinations with chemotherapy, targeted therapy, and immunotherapy, providing a range of therapeutic outcomes from cure to palliative care.
Yingze Ma, Hongxuan Yu, Shijie Shang, Shixin Shan, Dawei Chen   +4 more
wiley   +1 more source

In Vitro Effects of Photon Beam and Carbon Ion Radiotherapy on the Perineural Invasion of Two Cell Lines of Neurotropic Tumours

Life, 2023
Primary mucosal melanoma (PMM) and pancreatic ductal adenocarcinoma (PDAC) are two aggressive malignancies, characterized by intrinsic radio-chemoresistance and neurotropism, a histological feature resulting in frequent perineural invasion (PNI ...
Alexandra Charalampopoulou, Amelia Barcellini, Giuseppe Emanuele Frittitta, Giorgia Fulgini, Giovanni Battista Ivaldi, Giuseppe Magro, Marco Liotta, Ester Orlandi, Marco Giuseppe Pullia, Paola Tabarelli de Fatis, Angelica Facoetti   +10 more
doaj   +1 more source

Hypofractionated Spot Scanning Proton Therapy for Head and Neck Mucosal Melanoma: A Retrospective Analysis With Quality‐of‐Life Outcome

Head &Neck, Volume 48, Issue 5, Page 1208-1217, May 2026.
ABSTRACT Objective To evaluate clinical outcomes and quality of life (QOL) following hypofractionated spot‐scanning proton therapy (SSPT) for head and neck malignant mucosal melanoma (HNMM). Methods This retrospective study included 39 patients treated with SSPT (60–64 Gy[RBE] in 15–16 fractions) between 2013 and 2023.
Koichiro Nakajima, Hiromitsu Iwata, Gaku Takano, Daiki Kojima, Yukiko Hattori, Yusuke Tsuzuki, Shuou Sudo, Kensuke Hayashi, Toshiyuki Toshito, Hideo Fukano, Hiroyuki Ogino, Akio Hiwatashi   +11 more
wiley   +1 more source