Results 131 to 140 of about 11,242 (227)

Audiovestibular Outcomes After Parathyroidectomy in Primary Hyperparathyroidism

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
ABSTRACT Objective To prospectively evaluate audiovestibular outcomes following parathyroidectomy in patients with primary hyperparathyroidism (pHPT) using a comprehensive battery of audiological, vestibular, and patient‐reported outcome measures. Methods This prospective observational study included 31 adult patients undergoing parathyroidectomy for ...
Erdem Köroğlu, Halil Erdem Özel, Seda Erem Basmaz, Melikşah Çakır   +3 more
wiley   +1 more source

Oral Spermidine Supplementation Preserves Submandibular Gland Function After Radiotherapy: Mechanistic Insights and Use in a Phase II Randomized Clinical Trial

MedComm, Volume 7, Issue 8, August 2026.
Radiotherapy‐induced xerostomia severely impairs quality of life. Integrated multiomics, organoids, murine models, and a randomized Phase II trial identified spermidine as a key radiation‐responsive metabolite. Oral spermidine preserved salivary gland function, maintained acinar cell integrity through Golgi‐mediated posttranslational modifications ...
Yu Min, Kun Gao, Yingtong Liu, Lei Dai, Xingchen Peng   +4 more
wiley   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Radiobiology studies of gold nanoparticle‐enhanced radiosensitization in proton therapy

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Approximately 50%$\%$ of newly diagnosed cancer patients worldwide receive radiotherapy, most commonly with X‐rays. Proton therapy has emerged as a promising alternative, offering complementary advantages over conventional X‐rays due to its highly localized energy deposition at the Bragg peak, thereby reducing radiation exposure to ...
N. Fuster‐Martínez, D. H. Saucedo‐Cuberes, M. C. Jiménez‐Ramos, D. Esperante, J. M. Espino, J. Fuster, J. F. Belén‐Aguilar, L. González‐López, P. Huertas, S. Jimeno, I. Mingarro, D. Pascual, D. Suárez‐García, M. J. García‐Murria   +13 more
wiley   +1 more source

An ion treatment planning framework for inclusion of nanodosimetric ionization detail through cluster dose

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Nanodosimetry relates the cumulative or statistical moments of Ionization Detail (ID) with biological endpoints of relevance to cancer radiotherapy using charged particles. This association suggests to develop an additional physics‐detailed layer of modeling that may complement biological modeling and treatment planning.
Simona Facchiano, Ramon Ortiz, Remo Cristoforetti, Naoki D‐Kondo, Oliver Jäkel, Bruce Faddegon, Niklas Wahl   +6 more
wiley   +1 more source

Carbon ion radiotherapy at NIRS

Carbon ion radiotherapy at NIRS
In 1994, carbon ion radiotherapy was begun at the National Institute of Radiological Sciences using the Heavy Ion Medical Accelerator in Chiba, which was the worlds 􀂿rst heavy ion accelerator complex dedicated to medical use in a hospital environment. Among several types of ion species, carbon ions were selected for cancer therapy because they
openaire  

Photon minibeam‐based LATTICE radiotherapy for small and medium‐sized tumors: A dosimetric planning study

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Lattice radiotherapy (LRT) is a spatially fractionated technique that delivers three‐dimensional high‐dose vertices within tumors. However, conventional LRT is constrained by geometric limitations when applied to small and medium‐sized tumor volumes, primarily due to the large beam sizes that restrict optimal lattice pattern ...
Wei Wu, Nimita Shinde, Jiaxin Li, Isabelle Vanhaezebrouck, Kai Jiang, Yuting Lin, Qiang Li, Hao Gao   +7 more
wiley   +1 more source

Estimating the Sodium Content: A Case Series of Benign and Malignant Renal Tumours Using 23Na‐MRI at 3 T

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
23Na‐MRI at 3 T was applied to estimate TSC in patients with kidney tumours of different pathologies, which are indistinguishable on conventional imaging methods. The apparent TSC was significantly higher in renal oncocytomas (benign) compared to chromophobe renal cell carcinomas (malignant): 162 ± 58 mM vs. 71 ± 2 mM (p < 0.05).
Ines Horvat‐Menih, Jonathan R. Birchall, Maria J. Zamora‐Morales, Alice Bebb, Joshua D. Kaggie, Frank Riemer, Andrew B. Gill, Andrew N. Priest, Marta Wylot, Iosif A. Mendichovszky, Anne Y. Warren, James Jones, James N. Armitage, Thomas J. Mitchell, Grant D. Stewart, Mary A. McLean, Ferdia A. Gallagher   +16 more
wiley   +1 more source

Targeting and Energy‐Depleting Biomimetic Nanoparticles for Enhancing Combined Chemo‐Sonodynamic Therapy Against Esophageal Cancer

Rare Metals, Volume 45, Issue 8, August 2026.
ABSTRACT Esophageal cancer is the seventh leading cause of cancer death, and the energy depletion in cancer cells can be achieved through synergistic therapy. The integration of sonodynamic therapy and chemotherapy offers a promising comprehensive treatment strategy for esophageal cancer.
Mengya Li, Ruimei Jin, Shengxi Zhou, Jingan Li, Kun Zhang   +4 more
wiley   +1 more source