Results 141 to 150 of about 3,400,908 (256)

Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy.

Carbon ion radiotherapy shows great potential as a cure for X-ray-resistant tumors. Basic research suggests that the strong cell-killing effect induced by carbon ions is based on their ability to cause complex DNA double-strand breaks (DSBs).
478013, 478012, 478015, 478014, Shibata, Atsushi, 478011, 478010, Ohno, Tatsuya, Nakano, Takashi, Iwanaga, Mototaro, 小此木 範之, Kanai, Tatsuaki, Okonogi, Noriyuki, 中野 隆史, Noda, Shin-Ei, 478009, 478006, 478005, 478008, 478007, 478002, Matsumura, Akihiko, 478001, 478004, 478003, 478000, Tsuchida, Keisuke, 小林 大二郎, 大野 達也, Murata, Kazutoshi, Kobayashi, Daijiro, Niimi, Atsuko, Oike, Takahiro, 478016   +33 more
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Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, Volume 13, Issue 61, 3 November 2026.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Dose constraints in the rectum and bladder following carbon-ion radiotherapy for uterus carcinoma: a retrospective pooled analysis.

Carbon-ion radiotherapy (C-ion RT) provides better dose distribution in cancer treatment compared to photons. Additionally, carbon-ion beams provide a higher biological effectiveness, and thus a higher tumor control probability.
754201, 754189, 754200, 754203, 754202, 754186, 754188, 754187, Kato, Shingo, Nakano, Takashi, Wakatsuki, Masaru, Miyasaka, Yuhei, Okonogi, Noriyuki, Fukahori, Mai, Ohkubo, Yu, 754197, 754196, 754199, 754198, 754193, 754192, 754195, 754194, 754191, 754190, Kamada, Tadashi, Tsuji, Hiroshi   +26 more
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Colonic Explosion During Argon Plasma Coagulation: A Systematic Review of Risk Factors, Prevention, and Management

JGH Open, Volume 10, Issue 11, November 2026.
ABSTRACT Introduction Argon plasma coagulation (APC) is a non‐contact electrocoagulation technique widely used for hemostasis in gastrointestinal endoscopy. Despite its safety, rare but catastrophic complications such as colonic explosions have been reported.
Fariha Hasan, Ayesha Liaquat, Ishan Bhalgat, Ahmer Khan, Hareesha Rishab Bharadwaj, Dushyant Singh Dahiya, Shahryar Khan, Christina Tofani, Apeksha Shah, Anthony Infantolino   +9 more
wiley   +1 more source

Carbon ion radiotherapy in NIRS

Carbon ion radiotherapy in NIRS
High linear energy transfer (LET) charged particle therapy with carbon ions has been of interest in the treatment of malignant tumors because of better dose localization in the tumor volume and greater biologic effectiveness. In 1984, the Heavy Ion Medical Accelerator in Chiba (HIMAC) was constructed at the National Institute of Radiological Sciences ...
openaire   +1 more source

Multi-institutional Study of Carbon-ion Radiotherapy for Locally Advanced Pancreatic Cancer: Japan Carbon-ion Radiation Oncology Study Group (J-CROS) Study 1403 Pancreas.

The aim of this multi-institutional study was to evaluate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for locally advanced pancreatic cancer (LAPC).journal ...
Shinoto, Makoto, Kawashiro, Shohei, Ohno, Tatsuya, Okamoto, Masahiko, 745630, Nakano, Takashi, 745631, 745632, 745633, 745634, 745624, 745625, 745626, 745627, 745628, 745629, Nemoto, Kenji, Isozaki, Yuka, 745640, 745620, 745621, 745622, 745623, 745635, 745636, Kamada, Tadashi, 745637, 745638, 745639, 745619, Tsuji, Hiroshi, Yamada, Shigeru, Shioyama, Yoshiyuki   +32 more
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Alzheimer's Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 11, November 2026.
Alzheimer's disease involves Aβ/tau aggregation, neuroinflammation, BBB leakage, gut–brain dysfunction, and mitochondrial damage, causing neuronal loss. Nanodelivery enables combined small‐molecule and targeted therapies. Disease‐modifying biologics/chemicals, including anti‐Aβ antibodies, raise safety and access concerns. Exercise, cognitive training,
Gaoshuang Fu, Mingmin Pan, Qingling Sun, Guangxin Yue, Tong Lei   +4 more
wiley   +1 more source

Safety and Efficacy of Carbon-ion Radiotherapy Alone for Stage III Non-small Cell Lung Cancer.

We evaluated the efficacy and safety of carbon-ion radiotherapy (CIRT) alone for Stage III non-small-cell lung cancer (NSCLC).journal ...
866119, 866129, Nakajima, Mio, Yamamoto, Naoyoshi, Hayashi, Kazuhiko, Nomoto, Akihiro, 866120, 866131, 866130, 866122, Ogawa, Kazuhiko, Anzai, Makoto, 866121, Tsuji, Hiroshi, 866132, 866124, 866123, 866126, 866125, 866128, 866127   +20 more
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Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source

Carbon Ion Radiotherapy in Bone and Soft Tssue Sarcomas

The Heavy Ion Medical Accelerator in Chiba (HIMAC) is the world first heavy ion accelerator complex dedicated to medical use in a hospital environment.
Imaizumi, Takeshi, 554396, 554397, 554398, 554399, 554395, Okada, Tohru, 554404, 554405, 554406, 今泉 猛, 554407, 554400, 554401, 554402, 554403, 今井 礼子, 岡田 徹, 554408, 辻井 博彦, 辻 比呂志, Imai, Reiko, Matsunobu, Akira, 鎌田 正, Tsujii, Hirohiko, Kamada, Tadashi, 松延 亮, Tsuji, Hiroshi   +27 more
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