Results 1 to 10 of about 2,446,860 (342)
Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been
Claudia Melis +9 more
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Quantitative Characterization of the Chemical Space Governed by Human Carbonic Anhydrases and selenium-containing derivatives of solfonamides [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2022 Due to the fact that different isoforms of carbonic anhydrase play distinct physiological roles, their diseases/disorders involvement are different as well.
Behnam Rasti
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Carbonic anhydrase inhibitors for the treatment of glaucoma
Медицинская этика, 2023 Glaucoma is the leading cause of irreversible blindness. Its leading symptom and the most important initial link of the disease pathogenesis is represented by an increase of intraocular pressure (IOP).
V. Strakhov +6 more
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Identification of a carbonic anhydrase–Rubisco complex within the alpha-carboxysome
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Rubisco is responsible for the majority of inorganic carbon assimilation on Earth. To ensure efficient CO2 fixation, cyanobacteria and many autotrophic proteobacteria concentrate CO2 in the carboxysome, a bacterial organelle encapsulating ...
Cecilia Blikstad +8 more
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Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review
Current Issues in Molecular Biology, 2023 Osteopetrosis is a rare hereditary illness generated by failure in osteoclasts resulting in elevated bone densities. Patients with osteopetrosis possess several complications, like dental caries, earlier teeth loss, delayed eruption, malformed crowns and
Zikra Alkhayal +3 more
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Microbiology Spectrum, 2023 The ADC (AmpC) β-lactamase is universally present in the Acinetobacter baumannii chromosome, suggesting it may have a yet-to-be-identified cellular function. Using peptidoglycan composition analysis, we show that overexpressing the ADC-7 β-lactamase in A.
Jennifer M. Colquhoun +6 more
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Carbonic anhydrase is involved in calcification by the benthic foraminifer Amphistegina lessonii [PDF]
Biogeosciences, 2021 Marine calcification is an important component of the global carbon cycle. The mechanism by which some organisms take up inorganic carbon for the production of their shells or skeletons, however, remains only partly known.
S. de Goeyse +4 more
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Cancers, 2020 The acidic tumour microenvironment is now recognized as a tumour phenotype that drives cancer somatic evolution and disease progression, causing cancer cells to become more invasive and to metastasise.
Shen-Han Lee, J. Griffiths
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Frontiers in Chemistry, 2021 A series of novel 1H-1,2,3-triazole analogs (9a–j) were synthesized via “Click” chemistry and Suzuki–Miyaura cross-coupling reaction in aqueous medium. The compounds were evaluated for their carbonic anhydrase-II enzyme inhibitory activity in vitro.
Satya Kumar Avula +8 more
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Elucidating the role of metal ions in carbonic anhydrase catalysis
Nature Communications, 2020 Why metalloenzymes often show dramatic changes in their catalytic activity when subjected to chemically similar but non-native metal substitutions is a long-standing puzzle.
Jin Kyun Kim +7 more
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