Results 171 to 180 of about 2,453,486 (333)

Topiramate for the treatment of neonatal seizures and beyond

open access: yesEpilepsia, EarlyView.
Abstract Acute symptomatic neonatal seizures are one of the most common neurological disorders in newborns admitted to neonatal intensive care units and require prompt treatment. Up to 50% of neonatal seizures are refractory to first‐line medications such as phenobarbital (PB), and another 30% fail second‐line therapy.
Wolfgang Löscher, Janet S. Soul
wiley   +1 more source

Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine setting of oxygen/glucose deprivation followed by re-oxygenation and is associated with improved neuronal function in ischemic rats

open access: yesHeliyon
Carbonic anhydrases constitute a family of metalloenzymes vital for maintaining acid-base balance and regulating pH in physio-pathological processes. These findings suggest carbonic anhydrases as potential therapeutic targets for treating pH-associated ...
Sara Amiranda   +13 more
doaj  

A Spectrophotometric Method for the Assay of Carbonic Anhydrase Activity. [PDF]

open access: bronze, 1963
Per Olof Nyman   +4 more
openalex   +1 more source

Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α‐glycosidase enzymes inhibitors: The novel N,N′‐bis‐cyanomethylamine and alkoxymethylamine derivatives

open access: yesJournal of biochemical and molecular toxicology, 2018
Parham Taslimi   +7 more
semanticscholar   +1 more source

Unconventional structure and function of PHD domains from additional sex combs‐like proteins

open access: yesThe FEBS Journal, EarlyView.
A plant homeodomain (PHD) at the C terminus of additional sex combs‐like (ASXL) proteins is recurrently truncated in disease. In the current study, the ASXL PHD was shown not to bind histone modifications. Instead, a complex between the ASXL PHD and methyl CpG‐binding domain proteins 5 and 6 (MBD5/6) was investigated.
Cameron J. Reddington   +4 more
wiley   +1 more source

Facile synthesis of aminobiphenyl sulfonamides via Chan-Lam coupling and their biological evaluation as potent carbonic anhydrase inhibitors. [PDF]

open access: yesSci Rep
Sharif M   +9 more
europepmc   +1 more source

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