Results 61 to 70 of about 2,446,860 (342)

Peptide‐Based Biomaterials as a Promising Tool for Cancer Radiotherapy

Advanced Science, EarlyView.
This review provides a systematic overview of peptide‐based biomaterials in tumor radiotherapy, covering their roles as both radiosensitizers and radiopharmaceuticals. Peptide‐based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted‐peptide‐modified ...
Qian Wang, Xinhui Chu, Jianfeng Liu
wiley   +1 more source

Prospects for the application of inhibitors of carbonic anhydrase isoforms IX and XII in oncology

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Human carbonic anhydrase isoforms IX and XII play a key role in maintaining acid-base balance in solid tumors, creating a favorable microenvironment for the growth, invasion and metastasis of tumor cells.
S. А. Kalinin, Т. V. Sharonova, А. М. Malkova, S. V. Ageev, К. N. Semenov, V. V. Sharoyko   +5 more
doaj   +1 more source

Overcoming the Limits of Hypoxia in Photodynamic Therapy: A Carbonic Anhydrase IX-Targeted Approach.

Journal of the American Chemical Society, 2017
A major challenge in photodynamic cancer therapy (PDT) is avoiding PDT-induced hypoxia, which can lead to cancer recurrence and progression through activation of various angiogenic factors and significantly reduce treatment outcomes.
H. Jung, Jiyou Han, Hu Shi, Seyoung Koo, Hardev Singh, Hyo-Jin Kim, J. Sessler, J. Lee, Jong-Hoon Kim, Jong Seung Kim   +9 more
semanticscholar   +1 more source

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

Advanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex von Kriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot   +18 more
wiley   +1 more source

Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation

Brazilian Journal of Medical and Biological Research, 2001
We studied the relationship between alpha- and beta-adrenergic agonists and the activity of carbonic anhydrase I and II in erythrocyte, clinical and vessel studies. Kinetic studies were performed.
Puscas I., Coltau M., Gilau L., Pasca R., Domuta G., Baican M., Hecht A.   +6 more
doaj  

Microbially induced calcium carbonate precipitation through CO2 sequestration via an engineered Bacillus subtilis

Microbial Cell Factories
Background Microbially induced calcium carbonate precipitation has been extensively researched for geoengineering applications as well as diverse uses within the built environment. Bacteria play a crucial role in producing calcium carbonate minerals, via
Katie A. Gilmour, Prakriti Sharma Ghimire, Jennifer Wright, Jamie Haystead, Martyn Dade-Robertson, Meng Zhang, Paul James   +6 more
doaj   +1 more source

Carbonic Anhydrase Inhibition and the Management of Hypoxic Tumors

Metabolites, 2017
Hypoxia and acidosis are salient features of many tumors, leading to a completely different metabolism compared to normal cells. Two of the simplest metabolic products, protons and bicarbonate, are generated by the catalytic activity of the metalloenzyme
C. Supuran
semanticscholar   +1 more source

Brachyury‐Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment

Advanced Science, EarlyView.
This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong, Wenxiao Shi, Xingzhu Liu, Hang Yu, Yinghui Wu, Yanzhang Xia, Caichun Yue, Chongkai Yang, Cong Shen, Renjun Pei, Tianwen Xin, Hailong Pei, Jun Shen   +12 more
wiley   +1 more source

Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients

Clinical Ophthalmology, 2010
Adam M Moss, Alon Harris, Brent Siesky, Deepam Rusia, Kathleen M Williamson, Yochai ShoshaniDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USAAbstract: Topical hypotensive therapy with both timolol and carbonic
Adam M Moss, Alon Harris, Brent Siesky, et al   +3 more
doaj  

Recurrent hyperammonaemia in a patient with carbonic anhydrase VA deficiency

JIMD Reports, 2022
Carbonic anhydrase VA deficiency is a recently described inherited cause of paediatric hyperammonaemia. Most published cases describe patients with only one episode of hyperammonaemia whilst others report patients who had up to three metabolic crises ...
Christopher Stockdale, Ann Bowron, Marie Appleton, Ruth Richardson, Mark Anderson   +4 more
doaj   +1 more source