Results 11 to 20 of about 130,822 (183)

Carbonic Anhydrase II Deficiency: Unusual Presentation of the Arabic Mutation. A Case Report. [PDF]

Glob Pediatr Health
Carbonic anhydrase II deficiency is an extremely rare inborn error of metabolism that constitutes a triad osteopetrosis, renal tubular acidosis and intracerebral calcification.
Alayed Y, Alghamdi W, Alyousef R.
europepmc   +2 more sources

Low-Avidity Antibodies to Carbonic Anhydrase-I and -II in Autoimmune Chronic Pancreatitise [PDF]

The Scientific World Journal, 2002
Antibodies (Abs) to carbonic anhydrase (isoforms CA-I and CA-II) have been considered pathogenic factors in the development of autoimmune pancreatitis.
Maria J. Bartolomé, Gonzalo de las Heras, Marcos López-Hoyos   +2 more
doaj   +2 more sources

Aspirin: A Suicide Inhibitor of Carbonic Anhydrase II. [PDF]

Biomolecules, 2020
Carbonic anhydrase II (CAII) is a metalloenzyme that catalyzes the reversible hydration/dehydration of CO2/HCO3−. In addition, CAII is attributed to other catalytic reactions, including esterase activity. Aspirin (acetyl-salicylic acid), an everyday over-
Andring J, Combs J, McKenna R.
europepmc   +2 more sources

In silico Analysis of Selected Four-Leaf Water Clover (Marsilea species) Constituents as Human Acetyl Cholinesterase (hAchE), Carbonic Anhydrase II (hCA-II), and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Agents.

J Pharm Bioallied Sci
A four-leaf water clover (Marsilea species) has been reported to exhibit various biological activities. In the present study, we aimed to evaluate 23 selected constituents of a four-leaf water clover (Marsilea species) as potent inhibitory agents of ...
Rithanyaa R, Radhakrishnan N.
europepmc   +2 more sources

Bioinformatics approach based research of profile protein carbonic anhydrase II analysis as a potential candidate cause autism for the variation of learning subjects biotechnology [PDF]

JPBI (Jurnal Pendidikan Biologi Indonesia), 2017
This study aims to determine the needs of learning variations on Biotechnology courses using bioinformatics approaches. One example of applied use of bioinformatics in biotechnology course is the analysis of protein profiles carbonic anhydrase II as a ...
Dian Eka A. F. Ningrum, Mohamad Amin, Betty Lukiati   +2 more
doaj   +2 more sources

Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
A series of sulfamide fragments has been synthesised and investigated for human carbonic anhydrase inhibition. One of the fragments showing greater selectivity for cancer-related isoforms hCA IX and XII was co-crystalized with hCA II showing significant ...
Tatiana Sharonova, Petr Zhmurov, Stanislav Kalinin, Alessio Nocentini, Andrea Angeli, Marta Ferraroni, Mikhail Korsakov, Claudiu T. Supuran, Mikhail Krasavin   +8 more
doaj   +1 more source

Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111.
Mazin A. A. Najm, Walaa R. Mahmoud, Azza T. Taher, Safinaz E-S. Abbas, Fadi M. Awadallah, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran   +7 more
doaj   +1 more source

Microwave assisted solvent-free mannich bases: synthesis, characterization and effects of these compounds on HCA I and HCA II isozymes

Macedonian Journal of Chemistry and Chemical Engineering, 2021
Mannich bases (2a–d) of aromatic amines were synthesized by using a conventional microwave technique under solvent-free conditions and characterized by IR and NMR (1H and 13C) and elemental analysis.
Bülent Büyükkıdan, Nurgün Büyükkıdan, Metin Bülbül, Melek Yılmaz, Evren Derrun Arslanbay, Ekrem Tunca   +5 more
doaj   +1 more source

The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cardiovascular diseases are the leading cause of mortality worldwide. In recent years, the relationship between carbonic anhydrase inhibitors and atherosclerosis has attracted attention.
Onur Argan, Kübra Çıkrıkçı, Aybike Baltacı, Nahit Gencer   +3 more
doaj   +1 more source

Alpha-glucosidase and carbonic anhydrase inhibition studies of Pd(II)-hydrazide complexes

Arabian Journal of Chemistry, 2017
This study focused on the synthesis and characterization of hydrazide ligands and their respective Pd(II) complexes and used high throughput screening to determine their α-glucosidase and carbonic anhydrase II enzyme inhibition activities.
Qurrat-ul-Ain, Uzma Ashiq, Rifat Ara Jamal, Muhammad Saleem, Mohammad Mahroof-Tahir   +4 more
doaj   +1 more source