Results 11 to 20 of about 66,240 (319)

Synthesis and Enzymatic Evaluation of a Small Library of Substituted Phenylsulfonamido-Alkyl Sulfamates towards Carbonic Anhydrase II [PDF]

Molecules
A small library of 79 substituted phenylsulfonamidoalkyl sulfamates, 1b–79b, was synthesized starting from arylsulfonyl chlorides and amino alcohols with different numbers of methylene groups between the hydroxyl and amino moieties yielding intermediates
Toni C. Denner, Niels V. Heise, Ahmed Al-Harrasi, René Csuk   +3 more
doaj   +2 more sources

Azobenzene-based inhibitors of human carbonic anhydrase II [PDF]

Beilstein Journal of Organic Chemistry, 2015
Aryl sulfonamides are a widely used drug class for the inhibition of carbonic anhydrases. In the context of our program of photochromic pharmacophores we were interested in the exploration of azobenzene-containing sulfonamides to block the catalytic ...
Leander Simon Runtsch, David Michael Barber, Peter Mayer, Michael Groll, Dirk Trauner, Johannes Broichhagen   +5 more
doaj   +4 more sources

N-Cycloamino substituent effects on the packing architecture of ortho-sulfanilamide molecular crystals and their in silico carbonic anhydrase II and IX inhibitory activities. [PDF]

Acta Crystallogr C Struct Chem, 2022
Kolade SO, Izunobi JU, Gordon AT, Hosten EC, Olasupo IA, Ogunlaja AS, Asekun OT, Familoni OB.   +7 more
europepmc   +3 more sources

Arylsulfonamido-alkyl-sulfamates act as inhibitors of bovine carbonic anhydrase II

European Journal of Medicinal Chemistry Reports
A small library of arylsulfonamido-alkyl sulfamates was prepared by a two-step synthesis from readily available starting materials. The compounds were tested for their ability to inhibit bovine carbonic anhydrase II.
Toni C. Denner, Niels V. Heise, René Csuk   +2 more
doaj   +2 more sources

Comparative Analysis of Carbonic Anhydrase-II Expression Across Undescended Testes Sprague Dawley Model with Coenzyme Q10 Treatment. [PDF]

Acta Inform Med
Nurhadi P, Daryanto B, Purnomo AF, Kusworini, Alfandy TN.   +4 more
europepmc   +3 more sources

Carbonic Anhydrase II Deficiency in a Saudi Woman [PDF]

Clinical Medicine Insights: Case Reports, 2015
Objective Carbonic anhydrase (CA) II deficiency is a rare autosomal recessive disorder caused by mutation in the CA II gene that leads to osteopetrosis, renal tubular acidosis (RTA), and cerebral calcification.
Omar N. Alhuzaim, Ohoud M. Almohareb, Safiya M. Sherbeeni   +2 more
doaj   +4 more sources

In silico Analysis of Selected Four-Leaf Water Clover (Marsilea species) Constituents as Human Acetyl Cholinesterase (hAchE), Carbonic Anhydrase II (hCA-II), and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Agents

Journal of Pharmacy and Bioallied Sciences
A four-leaf water clover (Marsilea species) has been reported to exhibit various biological activities. In the present study, we aimed to evaluate 23 selected constituents of a four-leaf water clover (Marsilea species) as potent inhibitory agents of ...
Rithanyaa Ramesh, Radhakrishnan Narayanaswamy   +1 more
doaj   +2 more sources

Relationship between Changes in the Protein Folding Pathway and the Process of Amyloid Formation: The Case of Bovine Carbonic Anhydrase II. [PDF]

Int J Mol Sci, 2022
Melnik BS, Katina NS, Ryabova NA, Marchenkov VV, Melnik TN, Karuzina NE, Nemtseva EV.   +6 more
europepmc   +3 more sources

Synthesis of New 1H-1,2,3-Triazole Analogs in Aqueous Medium via “Click” Chemistry: A Novel Class of Potential Carbonic Anhydrase-II Inhibitors

Frontiers in Chemistry, 2021
A series of novel 1H-1,2,3-triazole analogs (9a–j) were synthesized via “Click” chemistry and Suzuki–Miyaura cross-coupling reaction in aqueous medium. The compounds were evaluated for their carbonic anhydrase-II enzyme inhibitory activity in vitro.
Satya Kumar Avula, Majid Khan, Majid Khan, Sobia Ahsan Halim, Ajmal Khan, Samia Ahmed Al-Riyami, Rene Csuk, Biswanath Das, Ahmed Al-Harrasi   +8 more
doaj   +1 more source

Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
A series of sulfamide fragments has been synthesised and investigated for human carbonic anhydrase inhibition. One of the fragments showing greater selectivity for cancer-related isoforms hCA IX and XII was co-crystalized with hCA II showing significant ...
Tatiana Sharonova, Petr Zhmurov, Stanislav Kalinin, Alessio Nocentini, Andrea Angeli, Marta Ferraroni, Mikhail Korsakov, Claudiu T. Supuran, Mikhail Krasavin   +8 more
doaj   +1 more source