Results 41 to 50 of about 5,754,497 (140)

Regulation of retinal proteome by topical antiglaucomatous eye drops in an inherited glaucoma rat model. [PDF]

PLoS ONE, 2012
Examination of the response of the retinal proteome to elevated intraocular pressure (IOP) and to the pharmacological normalization of IOP is crucial, in order to develop drugs with neuroptorective potential.
Maurice Schallenberg, Verena Prokosch, Solon Thanos   +2 more
doaj   +1 more source

A Combined in Silico and Structural Study Opens New Perspectives on Aliphatic Sulfonamides, a Still Poorly Investigated Class of CA Inhibitors

Biology, 2023
Aliphatic sulfonamides are an interesting class of carbonic anhydrase inhibitors (CAIs) proven to be effective for several carbonic anhydrase (CA) isoforms involved in pathologic states. Here we report the crystallographic structures of hCA II in complex
Emma Langella, Davide Esposito, Simona Maria Monti, Claudiu T. Supuran, Giuseppina De Simone, Vincenzo Alterio   +5 more
doaj   +1 more source

Challenges for the development of a biotic ligand model predicting copper toxicity in estuaries and seas [PDF]

, 2012
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 SETAC.An effort is ongoing to develop a biotic ligand model (BLM) that predicts copper (Cu) toxicity in estuarine and marine ...
Anna de Polo, Scrimshaw, MD, Mark D. Scrimshaw, de Polo, A   +3 more
core   +1 more source

Shell formation and bone strength in laying hens [PDF]

, 2013
In Sweden almost 3.8% of all eggs are ruined due to cracked eggshells as shell quality declines with age during the laying period. This is a concern for food safety as well as an economical problem.
Wistedt, Anna
core   +1 more source

Synthesis, Molecular Docking Analysis, ADMET and Drug Likeness Prediction of a Benzenesulfonamide Derivative Analogue of SLC-0111

Medical Sciences Forum, 2022
Carbonic anhydrases are metalloenzymes that regulate the interconversion of CO2 and H2CO3, a reaction involved in many physiological processes. A disfunction of these enzymes is known to induce many diseases such as glaucoma, epilepsy and cancer.
Yousra Ouafa Bouone, Abdeslem Bouzina, Nour-Eddine Aouf   +2 more
doaj   +1 more source

Glycolysis-related protein expression in thyroid cancer

Tumor Biology, 2017
We aimed to demonstrate the differences in the expression of glucose metabolism–related proteins according to the thyroid cancer subtypes and investigate the implications of these differences.
Ji Hae Nahm, Hye Min Kim, Ja Seung Koo
doaj   +1 more source

Synthesis carbonic anhydrase enzyme inhibition and antioxidant activity of novel benzothiazole derivatives incorporating glycine, methionine, alanine, and phenylalanine moieties

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Thirteen novel benzothiazole derivatives incorporating glycine, methionine, alanine, and phenylalanine were synthesised by facile acylation reactions through benzotriazole or DCC mediated reactions and their structures were identified by 1H-NMR, 13C-NMR,
Deniz Üzeroğlu Payaz, F. Zehra Küçükbay, Hasan Küçükbay, Andrea Angeli, Claudiu T. Supuran   +4 more
doaj   +1 more source

CARBONIC ANHYDRASE AS A MARKER OF OSTEOCLAST ACTIVITY IN THE REPAIR ZONE OF LONG BONE FRACTURE

Acta Biomedica Scientifica, 2012
In an experimental model of long bone fractures studied osteoclastic activity in the fracture zone. We used histological staining methods and histochemical staining with antibodies to carbonic anhydrase type II.
I. A. Shurygina, M. G. Shurygin, L. V. Rodionova, V. Ph. Lebedev, N. N. Dremina   +4 more
doaj  

Synthesis, characterization and in vitro inhibition of metal complexes of pyrazole based sulfonamide on human erythrocyte carbonic anhydrase isozymes I and II

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Sulfonamides represent an important class of biologically active compounds. A sulfonamide possessing carbonic anhydrase (CA) inhibitory properties obtained from a pyrazole based sulfonamide, ethyl 1-(3-nitrophenyl)-5-phenyl-3-((5-sulfamoyl-1,3,4 ...
Nurgün Büyükkıdan, Bülent Büyükkıdan, Metin Bülbül, Rahmi Kasımoğulları, Samet Mert   +4 more
doaj   +1 more source

Diarylethene derivatives and their applications. Salen derivatives in molecular recognition [PDF]

, 2010
A small series of aromatic water-soluble salophen derivates containing Fe(III), Ni(II) and Ti(IV) were synthesized and tested for their ability to recognize amino acids. In the case of the Fe(III)-salophen derivative no binding could be observed for any
Vomasta, Daniel
core   +1 more source