Results 31 to 40 of about 5,754,497 (140)

Investıgatıon of the Effects of Favipiravir and Oseltamivir Active Substances Used in the Treatment of Covid-19 on Carbonic Anhydrase I-II Isoenzymes and Acetylcholine Enzyme Activities in Vitro

Cumhuriyet Science Journal, 2023
Covid-19, originating from Wuhan, China, is a worldwide health problem. Immune system abnormalities caused by covid-19 lead to infections, septic shock, and severe multi-organ dysfunction.
Sueda Arık, Ümit Muhammet Koçyiğit
doaj   +1 more source

A new role for carbonic anhydrase 2 in the response of fish to copper and osmotic stress: Implications for multi-stressor studies [PDF]

, 2014
Copyright @ 2014 de Polo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
de Polo Anna, Scrimshaw, Mark D., Scrimshaw Mark D., Scrimshaw, MD, De Polo, A, Margiotta-Casaluci, Luigi; id_orcid, Margiotta-Casaluci, L, Margiotta-Casaluci Luigi, Lockyer, AE, Mark D. Scrimshaw (637445), Lockyer Anne E., de Polo, Anna, Anna de Polo, Anne E. Lockyer (107520), Luigi Margiotta-Casaluci, Margiotta-Casaluci, Luigi, Mark D Scrimshaw, Luigi Margiotta-Casaluci (637444), Lockyer, Anne E., Anna de Polo (637443), Anne E Lockyer   +20 more
core   +1 more source

Carbonic anhydrase inhibitory properties of some uracil derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Inhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4–12) to inhibit human CA I (hCA I) and II (hCA II) isoenzymes. The KI
Emir Alper Türkoğlu, Murat Şentürk, Claudiu T. Supuran, Deniz Ekinci   +3 more
doaj   +1 more source

Bioinformatics Tools for the Analysis of Active Compounds Identified in Ranunculaceae Species

Pharmaceuticals, 2023
The chemical compounds from extracts of three Ranunculaceae species, Aconitum toxicum Rchb., Anemone nemorosa L. and Helleborus odorus Waldst. & Kit.
Cătălina Mareş, Ana-Maria Udrea, Nicoleta Anca Şuţan, Speranţa Avram   +3 more
doaj   +1 more source

Interaction of Coumarin, Daphnetin, Fraxetin from Natural Materials with Carbanoic anhydrase II in Inhibiting Glaucoma

Sains Natural
This article explores the interaction of Coumarin compounds and their derivatives obtained from natural extracts with Carbonic anhydrase II protein in inhibiting Glaucoma computationally.
Rismi Verawati, Fajri Ikhsan, Okta Suryani   +2 more
doaj   +1 more source

Stereochemistry matters: Inhibition of carbonic anhydrase II by amino acid derived sulfamates depends on their absolute configuration

European Journal of Medicinal Chemistry Reports
Aminoalcohols were converted into the corresponding enantiomeric phenylsulfonamide sulfamates. These compounds proved to be inhibitors of carbonic anhydrase II.
Toni C. Denner, Elsa L. Klett, Niels V. Heise, René Csuk   +3 more
doaj   +1 more source

Microsecond Simulation Analysis of Carbonic Anhydrase – II in Complex with (+)- Cathechin Revealed Molecular Interactions Responsible for Its Amelioration Effect on Fluoride Toxicity [PDF]

, 2020
Fluorosis is a chronic condition caused by overexposure to fluoride, marked by impaired dental, skeletal, and non-skeletal health. In presence of excess fluoride ions, in severe cases calcification of the ligaments observed.
Pavan Kumar, Pindi, Pulala Raghuveer, Yadav, Sadam DV, Satyanarayana, Hussain, Syed   +3 more
core   +1 more source

Selective inhibition of carbonic anhydrase IX by sulphonylated 1,2,3-triazole incorporated benzenesulphonamides capable of inducing apoptosis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
In search of selective carbonic anhydrase (CA) IX inhibitors endowed with apoptotic inducing properties, we designed and synthesised two subsets of 4- and 3-(5-aryl-(4-phenylsulphonyl)-1H-1,2,3-triazol-1-yl)benzenesulphonamides.
Kiran Siwach, Amit Kumar, Harish Panchal, Rajiv Kumar, Jitender Kumar Bhardwaj, Andrea Angeli, Claudiu T. Supuran, Pawan K. Sharma   +7 more
doaj   +1 more source

Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
4-(3-(4-Substituted-phenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamides (9–16) were successfully synthesized and their chemical structures were confirmed by 1H NMR, 13C NMR, and HRMS spectra.
Halise Inci Gul, Ebru Mete, Parham Taslimi, Ilhami Gulcin, Claudiu T. Supuran   +4 more
doaj   +1 more source

SYNTHESIS, BIOCHEMICAL AND IN SILICO EXPLORATION OF NOVEL IMIDAZOLE BASED 1,2,3-TRIAZOLES AS POTENTIAL HIT AGAINST CARBONIC ANHYDRASE II ISOZYME [PDF]

Química Nova
This study aimed to synthesize novel compounds as more effective carbonic anhydrase II inhibitors. For this purpose, 2-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)-4,5-diphenyl-1H-imidazole (3) was reacted with 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde ...
Mumtaz Hussain, Pervaiz Ali Channar, Aisha A. Alsfouk, Syeda Abida Ejaz, Mubashir Aziz, Zahid Hussain, Ghulam Abbas Kandhro, Hafiz Muhammad Attaullah, Rabail Ujhan, Mushtaque Ali Jakhrani, Aamer Saeed, Qamar Abbas, Laith Abualigah   +12 more
doaj   +1 more source