Results 41 to 50 of about 130,822 (183)

A Combined in Silico and Structural Study Opens New Perspectives on Aliphatic Sulfonamides, a Still Poorly Investigated Class of CA Inhibitors

Biology, 2023
Aliphatic sulfonamides are an interesting class of carbonic anhydrase inhibitors (CAIs) proven to be effective for several carbonic anhydrase (CA) isoforms involved in pathologic states. Here we report the crystallographic structures of hCA II in complex
Emma Langella, Davide Esposito, Simona Maria Monti, Claudiu T. Supuran, Giuseppina De Simone, Vincenzo Alterio   +5 more
doaj   +1 more source

Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles

IUCrJ, 2014
Human carbonic anhydrases are zinc metalloenzymes that catalyze the hydration and dehydration of CO2 and HCO3 −, respectively. X-ray crystal structures of a variant of human carbonic anhydrase II in complex with four imidazole derivatives (imidazole, 1 ...
M. Aggarwal, Bhargav Kondeti, C. Tu, C. M. Maupin, D. Silverman, R. McKenna   +5 more
semanticscholar   +1 more source

Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
4-(3-(4-Substituted-phenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamides (9–16) were successfully synthesized and their chemical structures were confirmed by 1H NMR, 13C NMR, and HRMS spectra.
Halise Inci Gul, Ebru Mete, Parham Taslimi, Ilhami Gulcin, Claudiu T. Supuran   +4 more
doaj   +1 more source

Inactivation and adsorption of human carbonic anhydrase II by nanoparticles.

Langmuir, 2014
The enzymatic activity of human carbonic anhydrase II (HCAII) was studied in the presence of nanoparticles of different nature and charge. Negatively charged nanoparticles inhibit HCAII whereas no effect is seen for positively charged particles.
Anna Assarsson, I. Pastoriza‐Santos, C. Cabaleiro-Lago   +2 more
semanticscholar   +1 more source

SYNTHESIS, BIOCHEMICAL AND IN SILICO EXPLORATION OF NOVEL IMIDAZOLE BASED 1,2,3-TRIAZOLES AS POTENTIAL HIT AGAINST CARBONIC ANHYDRASE II ISOZYME [PDF]

Química Nova
This study aimed to synthesize novel compounds as more effective carbonic anhydrase II inhibitors. For this purpose, 2-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)-4,5-diphenyl-1H-imidazole (3) was reacted with 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde ...
Mumtaz Hussain, Pervaiz Ali Channar, Aisha A. Alsfouk, Syeda Abida Ejaz, Mubashir Aziz, Zahid Hussain, Ghulam Abbas Kandhro, Hafiz Muhammad Attaullah, Rabail Ujhan, Mushtaque Ali Jakhrani, Aamer Saeed, Qamar Abbas, Laith Abualigah   +12 more
doaj   +1 more source

Synthesis, Molecular Docking Analysis, ADMET and Drug Likeness Prediction of a Benzenesulfonamide Derivative Analogue of SLC-0111

Medical Sciences Forum, 2022
Carbonic anhydrases are metalloenzymes that regulate the interconversion of CO2 and H2CO3, a reaction involved in many physiological processes. A disfunction of these enzymes is known to induce many diseases such as glaucoma, epilepsy and cancer.
Yousra Ouafa Bouone, Abdeslem Bouzina, Nour-Eddine Aouf   +2 more
doaj   +1 more source

Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance Carbonic anhydrases catalyze the fast interconversion of carbon dioxide and water into bicarbonate and proton. In this study, we use the method of high-pressure cryocooling to capture the gaseous carbon dioxide in crystals of carbonic ...
Chae Un Kim, HyoJin Song, B. S. Avvaru, S. Gruner, Sangyoun Park, R. McKenna   +5 more
semanticscholar   +1 more source

Regulation of retinal proteome by topical antiglaucomatous eye drops in an inherited glaucoma rat model. [PDF]

PLoS ONE, 2012
Examination of the response of the retinal proteome to elevated intraocular pressure (IOP) and to the pharmacological normalization of IOP is crucial, in order to develop drugs with neuroptorective potential.
Maurice Schallenberg, Verena Prokosch, Solon Thanos   +2 more
doaj   +1 more source

Glycolysis-related protein expression in thyroid cancer

Tumor Biology, 2017
We aimed to demonstrate the differences in the expression of glucose metabolism–related proteins according to the thyroid cancer subtypes and investigate the implications of these differences.
Ji Hae Nahm, Hye Min Kim, Ja Seung Koo
doaj   +1 more source

Synthesis, characterization and in vitro inhibition of metal complexes of pyrazole based sulfonamide on human erythrocyte carbonic anhydrase isozymes I and II

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Sulfonamides represent an important class of biologically active compounds. A sulfonamide possessing carbonic anhydrase (CA) inhibitory properties obtained from a pyrazole based sulfonamide, ethyl 1-(3-nitrophenyl)-5-phenyl-3-((5-sulfamoyl-1,3,4 ...
Nurgün Büyükkıdan, Bülent Büyükkıdan, Metin Bülbül, Rahmi Kasımoğulları, Samet Mert   +4 more
doaj   +1 more source