Results 51 to 60 of about 66,240 (319)

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold [PDF]

, 2019
A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1).
Akdemir, A., Amoroso, R., Angeli, A., Carradori, S., Cirilli, R., De Filippis, B., De Monte, C., Guglielmi, P., Maccallini, C., Rotondi, G., Secci, D., Supuran, C. T.   +11 more
core   +2 more sources

Revisiting Zinc Coordination in Human Carbonic Anhydrase II [PDF]

Inorganic Chemistry, 2012
Carbonic anhydrase (CA, general abbreviation for human carbonic anhydrase II) is a well-studied, zinc-dependent metalloenzyme that catalyzes hydrolysis of carbon dioxide to the bicarbonate ion. The apo-form of CA (apoCA, CA where Zn(2+) ion has been removed) is relatively easy to generate, and reconstitution of the human erythrocyte CA has been ...
He, Song, David L, Wilson, Erik R, Farquhar, Edwin A, Lewis, Joseph P, Emerson   +4 more
openaire   +2 more sources

Stereochemistry matters: Inhibition of carbonic anhydrase II by amino acid derived sulfamates depends on their absolute configuration

European Journal of Medicinal Chemistry Reports
Aminoalcohols were converted into the corresponding enantiomeric phenylsulfonamide sulfamates. These compounds proved to be inhibitors of carbonic anhydrase II.
Toni C. Denner, Elsa L. Klett, Niels V. Heise, René Csuk   +3 more
doaj   +1 more source

Bioinformatics Tools for the Analysis of Active Compounds Identified in Ranunculaceae Species

Pharmaceuticals, 2023
The chemical compounds from extracts of three Ranunculaceae species, Aconitum toxicum Rchb., Anemone nemorosa L. and Helleborus odorus Waldst. & Kit.
Cătălina Mareş, Ana-Maria Udrea, Nicoleta Anca Şuţan, Speranţa Avram   +3 more
doaj   +1 more source

Biophysical evidence for intrinsic disorder in the C-terminal tails of the epidermal growth factor receptor (EGFR) and HER3 receptor tyrosine kinases [PDF]

, 2016
The epidermal growth factor receptor (EGFR)/ErbB family of receptor tyrosine kinases includes oncogenes important in the progression of breast and other cancers, and they are targets for many drug development strategies.
Bose, Ron, Keppel, Theodore R, Monsey, John, Murray, Elisa M, Sarpong, Kwabena, Zhu, Jian   +5 more
core   +2 more sources

3D multi-agent models for protein release from PLGA spherical particles with complex inner morphologies [PDF]

, 2008
In order to better understand and predict the release of proteins from bioerodible micro- or nanospheres, it is important to know the influences of different initial factors on the release mechanisms.
A Göpferich, A Göpferich, A Göpferich, A Göpferich, A Göpferich, A Zhao, AC Kilic, Ana Barat, C Nicholson, F Kang, Heather J. Ruskin, J Siepmann, JM Kisler, K Kosmidis, K Zygourakis, KD Vlugt-Wensink, M Sandor, M Zhang, Martin Crane, Q ul Ain, RP Batycky, S Feng, X Lam   +22 more
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

SYNTHESIS, BIOCHEMICAL AND IN SILICO EXPLORATION OF NOVEL IMIDAZOLE BASED 1,2,3-TRIAZOLES AS POTENTIAL HIT AGAINST CARBONIC ANHYDRASE II ISOZYME [PDF]

Química Nova
This study aimed to synthesize novel compounds as more effective carbonic anhydrase II inhibitors. For this purpose, 2-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)-4,5-diphenyl-1H-imidazole (3) was reacted with 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde ...
Mumtaz Hussain, Pervaiz Ali Channar, Aisha A. Alsfouk, Syeda Abida Ejaz, Mubashir Aziz, Zahid Hussain, Ghulam Abbas Kandhro, Hafiz Muhammad Attaullah, Rabail Ujhan, Mushtaque Ali Jakhrani, Aamer Saeed, Qamar Abbas, Laith Abualigah   +12 more
doaj   +1 more source

Method of Using Carbonic Anhydrase to Detect Hemolysis [PDF]

, 2011
A method and a test for using carbonic anhydrase (CA), particularly CA-I or CA-II, as a biomarker ofhemolysis. The method and test detect hemolysis by determining a percentage erythrocyte hemolysis in a specimen or sample of blood based upon ...
Kline, Jeffrey A., Zagorski, John
core  

The structure of a tetrameric α-carbonic anhydrase fromThermovibrio ammonificansreveals a core formed around intermolecular disulfides that contribute to its thermostability [PDF]

, 2014
Carbonic anhydrase enzymes catalyse the reversible hydration of carbon dioxide to bicarbonate. A thermophilic Thermovibrio ammonificans α-carbonic anhydrase (TaCA) has been expressed in Escherichia coli and structurally and biochemically characterized ...
Berg, Svein, Isupov, Michail N., James, Paul, Kotlar, Hans Kristian, Lioliou, Maria, Littlechild, Jennifer A., Saneei, Vahid, Sayer, Christopher   +7 more
core   +1 more source