Results 61 to 70 of about 130,822 (183)

Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1/SLC4A1

Journal of Physiology, 2013
•  Controversial results have been reported on the hypothesis that the cytosolic carbonic anhydrase II (CAII) of the red cell is largely bound to the cell's Cl−/HCO3− exchanger AE1, forming a ‘metabolon complex’ that greatly enhances transport activity ...
S. Al-Samir, Symeon Papadopoulos, Renate J. Scheibe, J. Meissner, J. Cartron, W. Sly, S. Alper, G. Gros, V. Endeward   +8 more
semanticscholar   +1 more source

Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism.

Biochemistry, 2007
Human carbonic anhydrase II (HCA II) is a zinc-metalloenzyme that catalyzes the reversible interconversion of CO2 and HCO3-. The rate-limiting step of this catalysis is the transfer of a proton between the Zn-bound solvent molecule and residue His64.
S. Z. Fisher, C. M. Maupin, M. Budayova-Spano, L. Govindasamy, C. Tu, M. Agbandje-McKenna, David N. Silverman, Gregory A. Voth, R. McKenna   +8 more
semanticscholar   +1 more source

Metalloprotein-inhibitor binding: human carbonic anhydrase II as a model for probing metal-ligand interactions in a metalloprotein active site.

Inorganic Chemistry, 2013
An ever-increasing number of metalloproteins are being discovered that play essential roles in physiological processes. Inhibitors of these proteins have significant potential for the treatment of human disease, but clinical success of these compounds ...
David P. Martin, Z. S. Hann, Seth M. Cohen   +2 more
semanticscholar   +1 more source

M1-Type Macrophages Secrete TNF-α to Stimulate Vascular Calcification by Upregulating CA1 and CA2 Expression in VSMCs

Journal of Inflammation Research, 2023
Xianqin Song,1 Yu Song,1 Quanping Ma,2 Kehua Fang,3 Xiaotian Chang1 1Medical Research Center of the Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 2Clinical Laboratory, The fourth People’s Hospital of Jinan ...
Song X, Song Y, Ma Q, Fang K, Chang X
doaj  

Entrapment of Carbon Dioxide in the Active Site of Carbonic Anhydrase II*♦

Journal of Biological Chemistry, 2008
The visualization at near atomic resolution of transient substrates in the active site of enzymes is fundamental to fully understanding their mechanism of action.
J. Domsic, B. S. Avvaru, Chae Un Kim, S. Gruner, M. Agbandje-McKenna, D. Silverman, R. McKenna   +6 more
semanticscholar   +1 more source

Overexpression of carbonic anhydrase II and Ki-67 proteins in prognosis of gastrointestinal stromal tumors.

World Journal of Gastroenterology, 2013
AIM To investigate the expression and prognostic value of carbonic anhydrase II (CA II) and Ki-67 in gastrointestinal stromal tumors (GISTs). METHODS One hundred and thirteen GIST patients admitted to Chinese People's Liberation Army General Hospital ...
Licheng Liu, Wen-tong Xu, Xin Wu, P. Zhao, Ya-li Lv, Lin Chen   +5 more
semanticscholar   +1 more source

N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome.

Proceedings of the National Academy of Sciences of the United States of America, 1988
Electrophoretic screening of (C57BL/6J x DBA/2J)F1 progeny of male mice treated with N-ethyl-N-nitrosourea revealed a mouse that lacked the paternal carbonic anhydrase II (CA II).
S. Lewis, R. Erickson, L. Barnett, P. Venta, R. Tashian   +4 more
semanticscholar   +1 more source

Energetics and dynamics of the proton shuttle of carbonic anhydrase II. [PDF]

Cell Mol Life Sci, 2023
Raum HN, Fisher SZ, Weininger U.
europepmc   +1 more source

Stereochemistry matters: Inhibition of carbonic anhydrase II by amino acid derived sulfamates depends on their absolute configuration

European Journal of Medicinal Chemistry Reports
Aminoalcohols were converted into the corresponding enantiomeric phenylsulfonamide sulfamates. These compounds proved to be inhibitors of carbonic anhydrase II.
Toni C. Denner, Elsa L. Klett, Niels V. Heise, René Csuk   +3 more
doaj  

A short, strong hydrogen bond in the active site of human carbonic anhydrase II.

Biochemistry, 2010
The crystal structure of human carbonic anhydrase II (HCA II) obtained at 0.9 A resolution reveals that a water molecule, termed deep water, Dw, and bound in a hydrophobic pocket of the active site forms a short, strong hydrogen bond with the zinc-bound ...
B. S. Avvaru, Chae Un Kim, Katherine H. Sippel, S. Gruner, M. Agbandje-McKenna, D. Silverman, R. McKenna   +6 more
semanticscholar   +1 more source