Results 91 to 100 of about 674,558 (235)

A novel thiadiazole-based dual inhibitor of carbonic anhydrase-IX and epidermal growth factor receptor targeting cancer: A combined and approach

Journal of Chemical Research
The co-expression of epidermal growth factor receptor and carbonic anhydrase-IX in aggressive tumors such as triple-negative breast cancer contributes to therapeutic resistance through proliferative signaling and hypoxia-mediated adaptation.
Eslam B Elkaeed, Hazem Elkady, Walid E Elgammal, Hazem A Mahdy, Dalal Z Husein, Ibrahim M Ibrahim, Hanan A Al-ghulikah, Ibrahim H Eissa, Ahmed M Metwaly   +8 more
doaj   +1 more source

Carbonic Anhydrase Inhibitor Modulation of Intraocular Pressure Is Independent of Soluble Adenylyl Cyclase. [PDF]

J Ocul Pharmacol Ther, 2023
Wiggins SV, Schreiner R, Ferreira J, Marmorstein AD, Levin LR, Buck J.   +5 more
europepmc   +1 more source

Microarrayed Allergen Molecules Distinguish IgE Sensitisation to Blomia tropicalis and Dermatophagoides pteronyssinus

Allergy, EarlyView.
This study established a microarray containing a representative panel of purified Blo t and Der p allergens for the identification of patients sensitised to Blo t and/or Der p. Results indicate that the microarray based on Blo t and Der p allergens is a useful tool for the identification of Blo t‐ and/or Der p‐sensitised patients. The microarray may be
Nishelle Dsouza, Siratcha Phanthong, Huey‐Jy Huang, Milena Weber, Eszter Sarzsinszky, Petra Zieglmayer, Gabrielle Pauli, Margarete Focke‐Tejkl, Mikhail Tulaev, Nikolina Todorovic, Walter Keller, Thomas Schlederer, Luis Caraballo, Anchalee Tungtrongchitr, Rudolf Valenta, Pongsakorn Tantilipikorn, Susanne Vrtala   +16 more
wiley   +1 more source

Efficacy of dorzolamide in improving ocular blood flow in patients with open-angle glaucoma: The Indian carbonic anhydrase inhibitor trial. [PDF]

Indian J Ophthalmol, 2023
Srikanth K, Khurana DA.
europepmc   +1 more source

Clinical and molecular features of PRCD‐associated retinopathy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To describe the clinical and genetic characteristics of patients with biallelic disease‐causing variants in the PRCD (Progressive Rod‐Cone Degeneration) gene. Methods Multicentre, retrospective cohort study of 19 patients from 13 families across nine reference centres in six countries.
Vasil Kostin, Karolina Kaminska, Marco Cattaneo, Enrico Ambrosini, Carmen Ayuso, Almudena Ávila‐Fernández, Béatrice Bocquet, Luisa Coutinho‐Santos, Benedetto Falsini, Lidia Fernandez‐Caballero Palomeque, Bohdan Kousal, Petra Liskova, Inmaculada Martín‐Mérida, María Juliana Ballesta‐Martínez, Daan Panneman, Susanne Roosing, Isabelle Meunier, José M. Millán, Monika Pankievič, Irene Perea‐Romero, Virginie Peter, Giorgio Placidi, Cristina Santos, Francesca Simonelli, Ana Berta Sousa, Francesco Testa, Marie Vajter, Marianna Weener, Mathieu Quinodoz, Carlo Rivolta, Giacomo Calzetti   +30 more
wiley   +1 more source

Response to comments on: Efficacy of dorzolamide in improving ocular blood flow in patients with open-angle glaucoma: The Indian carbonic anhydrase inhibitor trial. [PDF]

Indian J Ophthalmol, 2023
Ariga M, Nivean PD.
europepmc   +1 more source

Intraluminal stent removal after Paul glaucoma implant surgery: Intraocular pressure reduction and safety outcomes

Acta Ophthalmologica, EarlyView.
Abstract Purpose To evaluate the outcomes of intraluminal stent removal from the Paul glaucoma implant (PGI). Methods A retrospective observational study of all cases undergoing PGI stent removal from August 2022 to August 2025 at a single Danish tertiary centre. Primary endpoints were intraocular pressure (IOP) and IOP‐lowering medications.
Anne Studsgaard, Iben Bach Damgaard, Niklas Telinius   +2 more
wiley   +1 more source

Research progress on molecular mechanism of neuroprotective effects of acetazolamide under acute hypoxic exposure

环境与职业医学
Acute hypoxic exposure can induce functional brain impairment, driven by molecular mechanisms including mitochondrial dysfunction, intracellular calcium overload, glial cell activation and inflammatory responses, blood-brain barrier disruption, and ...
Qi FU, Yu WANG, Ruili GUAN, Yuankang ZOU, Kejun DU   +4 more
doaj   +1 more source

Inhibitory Effects and Kinetic-Docking Studies of Xanthohumol From Cones Against Carbonic Anhydrase, Acetylcholinesterase, and Butyrylcholinesterase

Natural Product Communications, 2019
Xanthohumol is an essential prenyl flavonoid of Humulus lupulus L. cones, and the taste of beer is due to this compound. Lately, xanthohumol has earned significant interest due to its potential anticancer, antigenotoxic, and adipogenesis effects. In this
Tuba Aydin, Murat Senturk, Cavit Kazaz, Ahmet Cakir   +3 more
doaj   +1 more source

Renal carbonic anhydrase

, 1982
Carbonic anhydrase is a zinc metalloenzyme widely distributed throughout the tissues of the body. This enzyme exists in a number of isozymic forms in most mammalian species.
R. E. Bulger, D. C. Dobyan
core   +1 more source