Carbonic anhydrase from Apis mellifera: purification and inhibition by pesticides
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 Carbonic anhydrase (CA) enzymes have been shown to play an important role in ion transport and in pH regulation in several organisms. Despite this information and the wealth of knowledge regarding the significance of CA enzymes, few studies have been ...
Ercan Soydan +5 more
doaj +1 more source
Longitudinal Photoreceptor Phenotype Observation and Therapeutic Evaluation of a Carbonic Anhydrase Inhibitor in a X-Linked Retinoschisis Mouse Model. [PDF]
Front Med (Lausanne), 2022 Liu M +5 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher +6 more
wiley +1 more source
Arylsulfonamido-alkyl-sulfamates act as inhibitors of bovine carbonic anhydrase II
European Journal of Medicinal Chemistry ReportsA small library of arylsulfonamido-alkyl sulfamates was prepared by a two-step synthesis from readily available starting materials. The compounds were tested for their ability to inhibit bovine carbonic anhydrase II.
Toni C. Denner +2 more
doaj +1 more source
Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as "Antidiabesity" Agents Based on Repurposing and Morphing of WB-4101. [PDF]
J Med Chem, 2022 Artasensi A +9 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville +6 more
wiley +1 more source
In vitro and in vivo activities of the carbonic anhydrase inhibitor, dorzolamide, against vancomycin-resistant enterococci. [PDF]
PeerJ, 2021 Abutaleb NS +3 more
europepmc +1 more source
Australian and New Zealand Glaucoma Society (ANZGS) Consensus on Interventional Glaucoma
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background Traditional reactive ‘wait and see’ approaches in glaucoma management often result in unacceptable rates of permanent vision loss. This consensus defines a proactive ‘interventional glaucoma’ framework tailored for the Australian and New Zealand healthcare context. Methods A modified Delphi consensus process was utilised, consisting
Graham A. Lee +12 more
wiley +1 more source
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background This trial aimed to evaluate the efficacy of oral acetazolamide in reducing cystoid fluid collections (CFC) and improving visual function in patients with X‐linked retinoschisis (XLRS). Methods In this investigator‐initiated, single centre, open‐label, randomised controlled trial, XLRS patients aged ≥ 12 years with fovea‐involving ...
Jonathan Hensman +15 more
wiley +1 more source
Carbonic anhydrase inhibitor induces otic hair cell apoptosis via an intrinsic pathway and ER stress in zebrafish larvae. [PDF]
Toxicol Rep, 2021 Matsumoto H +6 more
europepmc +1 more source