Results 101 to 110 of about 25,630 (237)

Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley   +1 more source

Experimental Carbonic Anhydrase Inhibitors for the Treatment of Hypoxic Tumors

Journal of Experimental Pharmacology, 2020
Claudiu T Supuran Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Florence 50019, ItalyCorrespondence: Claudiu T SupuranNeurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Via ...
Supuran CT
doaj  

Structural insights into θ‐type carbonic anhydrases 3 and 4: Tuning the directionality of CO2 hydration in a diatom

The FEBS Journal, EarlyView.
θ‐CA3 from a marine diatom has an N‐terminal transmembrane helix and two homologous catalytic domains. The enzyme functions as a dimer, with active sites formed near the dimer interface. A bicarbonate ion binds on the symmetry axis of the dimer and forms hydrogen bonds with both monomers, thereby activating θ‐CA3 and tuning CO2 hydration activity ...
Hiroto Negoro, Atsuki Ohsawa, Ginga Shimakawa, Hideaki Tanaka, Yusuke Matsuda, Genji Kurisu   +5 more
wiley   +1 more source

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

Insect Molecular Biology, EarlyView.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour, Angelo José Rinaldi, Eulálio Gutemberg Dias dos Santos, Gabriely Teixeira Bhering Faria, Ana Márcia Escocard de Azevedo Manhães, Jorge Fernando Pereira, Alexander Machado Auad, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +8 more
wiley   +1 more source

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, EarlyView.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

CO2‐sensitive K+ channel traffic affects stomata and whole‐plant water use

Journal of Integrative Plant Biology, EarlyView.
CO2‐responsive regulation of membrane trafficking influences the density of the potassium ion (K+) channel KAT1 at the plasma membrane. CO2‐sensitive traffic, dependent on trafficking by the SNARE SYP121, impacts stomatal gas exchange and plant growth.
Zhiyi Yu, Sakharam Waghmare, Sahar Farami, Michael R. Blatt, Rucha Karnik   +4 more
wiley   +1 more source

Dietary L‐Tyrosine Sustains Egg Production and Quality by Modulating Promoter CpG Methylation, Gene Expression, and Hormone Profiles in Reproductive Signalling Pathways of Aged Laying Hens

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Managing prolactin (PRL)‐mediated reproductive suppression is critical for maintaining egg production in commercial laying hens. L‐tyrosine (TYR), a precursor of dopamine (DA), may counteract age‐related reproductive decline by suppressing PRL, thereby sustaining productivity and egg quality in late‐phase laying hens.
Hasan Hüseyin İpçak
wiley   +1 more source

Extending the Farquhar–von Caemmerer–Berry photosynthesis model to account for various photorespiratory bypasses

New Phytologist, EarlyView.
We extend a widely used C3‐photosynthesis model to account for various photorespiratory bypasses, thereby, providing a useful resource and framework that enforces future novel bypass work and scrutinize if the results go counter to theory. Our model analyses show that of the 17 published bypass pathways, full‐decarboxylating bypasses (that have been ...
Xinyou Yin, Kaining Jin, Guoxin Chen, Tiegang Lu   +3 more
wiley   +1 more source

Time‐series multi‐omics analysis of micronutrient stress in Sorghum bicolor reveals iron and zinc crosstalk and regulatory network conservation

Plant Biology, EarlyView.
Overlap between Fe and Zn responsive gene regulatory networks (GRNs) were found, indicative of micronutrient crosstalk, and conservation of root and leaf GRNs and genes suggests strong constraint on homeostasis networks in plants. Abstract Micronutrient stress impacts growth, biomass production, and grain yield in crops.
A. Mishra, A. Bhat, S. Kumari, R. Sharma, J. Braynen, D. Tadesse, S. El Alaoui, S. Seaver, N. Grosjean, D. Ware, M. Xie, T. Paape   +11 more
wiley   +1 more source

Vision outcomes in dogs with primary glaucoma surgically treated with lensectomy and endolaser cyclophotocoagulation after an Ahmed valve gonioimplantation failure

Veterinary Ophthalmology, Volume 28, Issue 2, Page 207-217, March 2025.
Abstract Objective The aim of this study was to retrospectively evaluate vision outcomes of dogs with primary angle closure glaucoma (PACG) that underwent Ahmed valve gonioimplantation (AVG) followed by lensectomy and endolaser cyclophotocoagulation (ECP) with or without bleb resection after AVG failure.
Bactelius Turicea, Christian L. Munevar, Sydney G. Edwards, Lana L. Linton   +3 more
wiley   +1 more source