Results 141 to 150 of about 674,558 (235)

Pressure‐Induced Changes in Intracellular pH Facilitate the Myogenic Response of Rat Small Tail Arteries

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim The myogenic response contributes considerably to blood flow autoregulation. Intracellular pH (pHi) has a substantial impact on small artery contractility. However, the role of putative pHi changes during myogenic constriction is unknown.
Ulrike Krien, Rudolf Schubert
wiley   +1 more source

Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1‐linked episodic ataxia in mice

British Journal of Pharmacology, Volume 183, Issue 20, Page 6179-6198, October 2026.
Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville, Ryan F. Yoshimura, Hanh A. Nguyen, Ruiming Zhao, Derk J. Hogenkamp, Steve A. N. Goldstein, Geoffrey W. Abbott   +6 more
wiley   +1 more source

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

Insect Molecular Biology, Volume 35, Issue 5, Page 556-575, October 2026.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour, Angelo José Rinaldi, Eulálio Gutemberg Dias dos Santos, Gabriely Teixeira Bhering Faria, Ana Márcia Escocard de Azevedo Manhães, Jorge Fernando Pereira, Alexander Machado Auad, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +8 more
wiley   +1 more source

Carbonic anhydrase inhibitor retards EBV induced B-cell transformation.

(A-B) PBMCs isolated from two individual donors (donor #1 and donor #2) were infected with GFP-EBV (MOI ~10) in the absence (DMSO control) or in the presence of 0.1 mM carbonic anhydrase inhibitor S4 for 28 days.
Chandrima Gain (8486763), Shatadru Ghosh Roy (18258328), Samaresh Malik (8486766), Subhadeep Nag (18258325), Bireswar Bhattacharya (17447583), Joyanta Biswas (18258322), Dipanjan Ghosh (5344622), Purandar Sarkar (10180880), Abhik Saha (177355)   +8 more
core   +1 more source

Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?

Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley   +1 more source

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, Volume 35, Issue 5, Page 576-593, October 2026.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

Case Report: Carbonic anhydrase inhibitor brinzolamide dramatically improved the morphology and also function of a patient with RS1 mutation. [PDF]

Front Pharmacol
Ren Y, Liu S, Rong J, Wang D, Diao M, Zhang Y, Tian S, Shang M, Song C, Guan Y, Wang Z, Pang J.   +11 more
europepmc   +1 more source

Carbonic Anhydrase Inhibitor Acetazolamide Enhances CHOP Treatment Response and Stimulates Effector T-Cell Infiltration in A20/BalbC Murine B-Cell Lymphoma. [PDF]

Int J Mol Sci, 2020
Méhes G, Matolay O, Beke L, Czenke M, Pórszász R, Mikó E, Bai P, Berényi E, Trencsényi G.   +8 more
europepmc   +1 more source

De Novo Discovery of Bioactive Cyclic Peptides via Cellular Selection of Genetically Encoded Libraries

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Genetically encoded cyclic peptide libraries can be employed in cellular selection platforms to identify cyclic peptide inhibitors for therapeutic targets by directly selecting for desired biological activities. This review systematically summarizes representative studies and suggests future opportunities for using cellular selection for de novo cyclic
Linwei Yang, Abhijit Behera, Hannah J. Meyers, Tina Wang   +3 more
wiley   +1 more source

An ureido-substituted benzenesulfonamide carbonic anhydrase inhibitor exerts a potent antitumor effect in vitro and in vivo. [PDF]

Exp Hematol Oncol
Gazzaroli G, Tavani C, Filiberti S, Massardi ML, Turati M, Garattini G, Peat TS, Pieraccini G, Angeli A, Supuran CT, Carta F, Giacomini A, Ronca R.   +12 more
europepmc   +1 more source