Results 141 to 150 of about 25,630 (237)

Oral Spermidine Supplementation Preserves Submandibular Gland Function After Radiotherapy: Mechanistic Insights and Use in a Phase II Randomized Clinical Trial

MedComm, Volume 7, Issue 8, August 2026.
Radiotherapy‐induced xerostomia severely impairs quality of life. Integrated multiomics, organoids, murine models, and a randomized Phase II trial identified spermidine as a key radiation‐responsive metabolite. Oral spermidine preserved salivary gland function, maintained acinar cell integrity through Golgi‐mediated posttranslational modifications ...
Yu Min, Kun Gao, Yingtong Liu, Lei Dai, Xingchen Peng   +4 more
wiley   +1 more source

Obstructive Sleep Apnea: Epidemiology, Pathophysiology, Complications, Diagnosis, Management, and Emerging Fibrosis‐Linked Remodeling

MedComm, Volume 7, Issue 8, August 2026.
Obstructive sleep apnea (OSA) is characterized by recurrent upper‐airway collapse, which generates key nocturnal stressors including intermittent hypoxia, sleep fragmentation, intrathoracic pressure stress, and sympathetic activation. These physiological disturbances converge on shared biological mechanisms, including oxidative stress, inflammation ...
Nhi Ho Thi Thuy, Thị Hằng Giang Phan, Ali Hussein Eid, Paola Maccioccu, Stefania Camboni, Gavino Casu, Anna Maria Posadino, Roberta Giordo, Gianfranco Pintus   +8 more
wiley   +1 more source

Metabolite‐Driven Biological Activity of Mandragora autumnalis and Spartium junceum: A Comparative LC‐MS/MS Study on Antioxidant, Cholinesterase, and Carbonic Anhydrase Inhibition

ChemistryOpen, Volume 15, Issue 8, August 2026.
Low‐molecular‐weight phenolic acids in M. autumnalis were associated with antioxidant activity, AChE, and hCA inhibition effects, whereas flavonoid‐rich S. junceum displayed BChE‐oriented inhibition effect and antibacterial activity. LC‐MS/MS‐based metabolite profiling linked distinct chemical compositions to bioactivity patterns, supporting further ...
Kubra Aslan, Esra Elbir, Yusuf Bicakci, Silanur Ozdogan, Mustafa Abdullah Yilmaz, Ilhami Gulcin   +5 more
wiley   +1 more source

Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding. [PDF]

PeerJ, 2018
Smirnov A, Zubrienė A, Manakova E, Gražulis S, Matulis D.   +4 more
europepmc   +1 more source

Human Nasal and Bronchial Epithelium in Cystic Fibrosis: Differences in Expression of Airway pH Regulatory Proteins

Pediatric Pulmonology, Volume 61, Issue 8, August 2026.
ABSTRACT Background Decreased apical bicarbonate transport into the airway surface liquid (ASL) has been associated with decreased ASL pH, which can have adverse respiratory effects. However, the human CF epithelium can normalize ASL pH. Thus, we hypothesized that pH regulatory proteins other than the CFTR could be altered in the CF epithelium ...
Michael D. Davis, Laura Smith, Yi Zhao, Rania Abdul Rahman, Faiza Khalid, James Chmiel, Katie Boyne, Ivana A. Daniels, Benjamin Gaston, Nadzeya Marozkina   +9 more
wiley   +1 more source

DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity

Small, Volume 22, Issue 43, 3 August 2026.
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley   +1 more source

Advancing Treatment of Degenerative Eye Diseases at the Nanoscale

Smart Medicine, Volume 5, Issue 4, August 2026.
Nanotherapeutics possess the potential to overcome longstanding bottlenecks in treating degenerative ophthalmic diseases. With a highly tunable surface chemistry, nanotechnology platforms can be customized to navigate specific anatomical barriers in the eye and target pathways of diseases.
Li Yao Jin, Evashiniee G. P. Selvam, Qinsong Mei, Chi D. Luu, Yeannie H. Y. Yap, Daniel B. L. Teh   +5 more
wiley   +1 more source

Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice. [PDF]

Int J Mol Sci, 2017
Noma N, Fujii G, Miyamoto S, Komiya M, Nakanishi R, Shimura M, Tanuma SI, Mutoh M.   +7 more
europepmc   +1 more source

Retinal oxygen saturation and retinal vessel diameter in glaucoma patients before and after trabeculectomy

Acta Ophthalmologica, Volume 104, Issue 5, Page 544-550, August 2026.
Abstract Purpose To compare retinal vessel oxygen saturations and diameters before, 1 and 3 months after trabeculectomy. Methods Retinal oxygen saturations and vessel diameters were obtained using retinal oximetry. The effect of the postoperative intraocular pressure (IOP) decrease on the arteriovenous difference (AV‐difference) was evaluated ...
S. Kemp, A. Ahmadzadeh, B. Schmidt, O. N. Klefter, L. Kessel, D. Bach‐Holm   +5 more
wiley   +1 more source

Levetiracetam inhibits the Na+ HCO3− transporter Ncbe/NBCn2 (Slc4a10) in the choroid plexus of mice

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Aim The Na+‐dependent Cl−/HCO3− exchanger Ncbe/NBCn2 (Slc4a10) constitutes a major basolateral HCO3− uptake pathway in the choroid plexus and contributes to cerebrospinal fluid secretion and pH regulation. This study examined whether levetiracetam inhibits Ncbe/NBCn2‐mediated transport and alters cerebrospinal fluid acid–base balance ...
Laura Øllegaard Johnsen, Lasse Messell Desdorf, Nicoline Stærke Jensen, Jeppe Praetorius, Helle Hasager Damkier   +4 more
wiley   +1 more source