Results 151 to 160 of about 674,558 (235)

A novel sulfamoylphenyl-dihydro-thiadiazole derivative as a dual EGFR and carbonic anhydrase inhibitor for cancer therapy. [PDF]

PLoS One
Eissa IH, Elkady H, Elgammal WE, Mahdy HA, Husein DZ, Amin FG, Elsheshiny AAA, Abdelfattah SS, Alsfouk AA, Elkaeed EB, Metwaly AM.   +10 more
europepmc   +1 more source

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, Renzo Luisi   +9 more
wiley   +2 more sources

Carbonic anhydrase based environmental bioanalysis

, 2004
Carbonic anhydrase (CA) is a metalloenzyme catalizing the reversible idratation of CO2 in H+ and HCO3-. It is an ubiquitous enzyme in bacteria, plant and animal kingdoms, playing a fundamental role in a number of physiolgical processes. Previous studies
E. Erroi, GIORDANO, Maria Elena, LIONETTO, Maria Giulia, CARICATO, Roberto, SCHETTINO, Trifone   +4 more
core  

Bacterial Carbonic Anhydrase Inhibitor CAI0019 Demonstrates Efficacy in <i><i>Enterococcus faecium</i></i> Septicemic Peritonitis Mouse Model While Sparing the Microbiome. [PDF]

ACS Infect Dis
Abutaleb NS, Holly KJ, Metcalfe CK, Abouelkhair AA, Tharra PR, Shrinidhi A, Abdelsattar AS, Burgo V, Melotte G, Akin-Olabiyi T, Knoblauch S, Ramaswamy R, Woodson C, Thirumalaikumar VP, Rodriguez JA, Yeo FJ, Snell OC, Nocentini A, Sundararajan A, Olson MR, Supuran CT, Seleem MN, Flaherty DP.   +22 more
europepmc   +1 more source

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, Volume 32, Issue 35, 19 September 2026.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm, Jachym Hrusak, Paul E. Reyes‐Gutierrez, Milan Vrabel   +6 more
wiley   +1 more source

Investigating the Anti-Inflammatory Potential of SLC-0111: A Carbonic Anhydrase Inhibitor Targeting Cyclooxygenase-Mediated Inflammatory Pathways in a Carrageenan-Induced Rat Model. [PDF]

J Biochem Mol Toxicol
Doğan A, Yanılmaz EMB, Karakoc G, Parlar A, Annaç E, Lolak N, Akocak S.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, Volume 20, Issue 9, Page 2296-2322, September 2026.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Lasamide, a Potent Human Carbonic Anhydrase Inhibitor from the Market: Inhibition Profiling and Crystallographic Studies. [PDF]

ACS Med Chem Lett
Baroni C, D'Agostino I, Renzi G, Kilbile JT, Tamboli Y, Ferraroni M, Carradori S, Capasso C, Carta F, Supuran CT.   +9 more
europepmc   +1 more source

Charting Morphotoxicity With Complementary Embryo Models

Advanced Healthcare Materials, Volume 15, Issue 35, 18 September 2026.
Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx, Pauline L. Balder, Romy M. L. Verhagen, Vinidhra Shankar, Barry Jutten, Pinak Samal, Timo Rademakers, Clemens A. van Blitterswijk, Stefan Giselbrecht, Erik J. Vrij   +9 more
wiley   +1 more source

Carbonic anhydrase inhibitor alleviates retinal barrier toxicity in paclitaxel-induced retinopathy and macular edema by inhibiting CAXIV. [PDF]

Int Ophthalmol
Ye YT, Niu YL, Zhou ZY, Sun Y, Chang TF, Jing YT, Bai Q, Chu ZJ.   +7 more
europepmc   +1 more source