Summary Carbonic anhydrases (CAs) are ubiquitous metalloenzymes that catalyze the reversible hydration of CO2, enabling fundamental processes in organisms across all domains of life. Among all CAs, the role of mitochondrial βCA remains poorly understood. Here, we identify a mitochondrial βCA, βCA6, as a key regulator of branched‐chain amino acid (BCAA)
Naveen Sharma +2 more
wiley +1 more source
An atlas of plant selenium metabolism
Summary Selenium (Se) is not only a rare and toxic element but also an essential micronutrient for humans and animals that is often in short supply. Terrestrial plants do not require Se, but it can have growth‐promoting or negative effects, depending on the exposure level.
Jeroen van der Woude +3 more
wiley +1 more source
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Papillomacular retinoschisis associated with glaucoma: Response to topical carbonic anhydrase inhibitor. [PDF]
Haruta M, Handa S, Yoshida S.
europepmc +1 more source
Role of Histidine‐Containing Peptoids in Accelerating the Kinetics of Calcite Growth
Amphiphilic histidine‐containing peptoids mimic carbonic anhydrase (CA) to accelerate calcite step growth. In the presence of Zn2+, they promote the deprotonation of HCO3−, the desolvation of Ca2+, and the reorganization of interfacial hydration layers, thereby reducing the activation barrier for calcite growth.
Mingyi Zhang +5 more
wiley +1 more source
Maize Anther Development Involves Translated Open Reading Frames From 3′ Untranslated Regions
This study examined the translation activity across ten stages of maize anther development, integrating transcriptome and small‐peptide data. It linked mutations in translated 3' ORFs to anther sterility, exemplified by Zm00001eb417050_3' ORF (known as APV1). In addition, the data indicated that maize anthers could assimilate CO2 through the stomata in
Chunyu Wang +8 more
wiley +1 more source
The Evolution of Giant Clam Science: From Foundational Studies to Emerging Frontiers
This review synthesizes nearly two centuries of giant clam research, identifying dominant themes, knowledge gaps, and emerging opportunities. Ecology, physiology, aquaculture, genomics, and biomineralization dominate the field, whereas anatomy and biotechnology remain underexplored. Future progress requires stronger integration of genomics, physiology,
Anthony Fam +4 more
wiley +1 more source
A practical and efficient CBr4‐mediated metal‐free route for sulfonamide synthesis is presented under batch, ultrasonic, and continuous‐flow conditions. The protocol demonstrates excellent substrate scope, reduced reaction times, and mild operating conditions, highlighting a scalable alternative to traditional iodine‐mediated methods in modern ...
Alageswaran Jayaram +6 more
wiley +1 more source
Carbonic Anhydrase Inhibitor Acetazolamide Enhances CHOP Treatment Response and Stimulates Effector T-Cell Infiltration in A20/BalbC Murine B-Cell Lymphoma. [PDF]
Méhes G +8 more
europepmc +1 more source
6-Methylsulfinylhexyl isothiocyanate activates carbonic anhydrase-dependent HCO<sub>3</sub> <sup>-</sup>/H<sup>+</sup>/Na<sup>+</sup>/Ca<sup>2+</sup> transport via SLC4As-NHE-NCX-PMCA axis in odontoblasts. [PDF]
Abstract figure legend 6‐Methylsulfinylhexyl isothiocyanate (6‐MSITC, hexaraphane), a wasabi sulfinyl compound, activates intracellular carbonic anhydrase (CA)‐mediated sequential HCO3−, Na+, H+ and Ca2+ transport through an activation axis involving HCO3−‐transporting solute carrier family 4 (SLC4As), the Na+–H+ exchanger (NHE), the Na+–Ca2+ exchanger
Furusawa Y +9 more
europepmc +2 more sources

