Results 161 to 170 of about 25,630 (237)

Beyond Neddylation Inhibition: X‑ray Structures Reveal Carbonic Anhydrase Isoform Selectivity of Pevonedistat. [PDF]

ACS Med Chem Lett
Baroni C, Ferraroni M, Supuran CT, Angeli A.   +3 more
europepmc   +1 more source

Efficacy of additional topical betamethasone in persistent cystoid macular oedema after carbonic anhydrase inhibitor treatments in retinitis pigmentosa. [PDF]

BMJ Open Ophthalmol, 2018
Kitahata S, Hirami Y, Takagi S, Kime C, Fujihara M, Kurimoto Y, Takahashi M.   +6 more
europepmc   +1 more source

1‐Aryl‐6,7‐Dimethoxy‐3,4‐Dihydroisoquinoline‐2(1H)‐Sulfonamides as hCA XII Selective Inhibitors: Experimental and Theoretical Studies to Interrogate the Isoform Selectivity

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
Experimental and theoretical studies have disclosed the more relevant structural requirements for effective inhibition and an impressing selectivity toward tumor‐expressed hCA XII isoform over hCA II. Human carbonic anhydrase XII (hCA XII) represents an important pharmacological target for different types of cancer.
Federico Ricci, Anna Di Fiore, Andrea Angeli, Laura De Luca, Francesca Mancuso, Davide Esposito, Giuseppina De Simone, Claudiu T. Supuran, Rosaria Gitto   +8 more
wiley   +1 more source

Novel Inhibitors of Carbonic Anhydrase I and II Identified by High Throughput Virtual Screening and Validated by X‐Ray Crystallography

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
High‐throughput virtual screening identifies novel carbonic anhydrase II ligands from large chemical libraries, enabling rapid hit discovery. Structural validation by X‐ray crystallography confirms the predicted binding modes and reveals key protein–ligand interactions.
Asher L. Brandt, Joseph Venditto, Marta Ferraroni, Claudiu T. Supuran, Andrea Angeli   +4 more
wiley   +1 more source

Isoxazole-Thiazole Hybrids: Synthesis, Structural Characterisation, Carbonic Anhydrase Inhibition, and Molecular Docking Studies. [PDF]

Molecules
Berber N, Türkeri ÖN, Başoğlu F, Çıkrıkcı K, Ergün A, Gencer N.   +5 more
europepmc   +1 more source

X-ray analysis of complexes of carbonic anhydrase II with 1,3-oxazole-containing sulfonamide derivatives elucidates the structural basis for their exceptionally high inhibitory potency. [PDF]

Acta Crystallogr F Struct Biol Commun
Stoliarskaia MY, Borisevich SS, Myaskov EO, Shetnev AA, Korsakov MK, Nikonov OS.   +5 more
europepmc   +1 more source

Neuroprotective and Renoprotective Potential of a Hydroethanolic Extract From the Aerial Parts of Mattiastrum paphlagonicum Bornm. (Boraginaceae). [PDF]

Chem Biodivers
Kayabaş Avşar A, Büker E, Yildirim E, Casoni D, Cobzac SCA.   +4 more
europepmc   +1 more source

Glycosyl Coumarins as Selective Inhibitors of Tumor-Associated Carbonic Anhydrase IX and XII: Synthesis, Structure-Activity Relationships, and Molecular Modeling. [PDF]

Int J Mol Sci
Le Pors MS, Aznar I, Giovannuzzi S, Supuran CT, Lavecchia MJ, Colinas PA.   +5 more
europepmc   +1 more source

Functional integration of LCIB, a component of the algal carbon-concentrating mechanism, enhances carbon assimilation, nitrogen-use efficiency, and biomass in tobacco. [PDF]

Front Plant Sci
Barsoum M, Buntru M, Schillberg S, Nölke G.   +3 more
europepmc   +1 more source

Systematic modeling of porphyrin-based photosensitizers for inhibiting Mycobacterium tuberculosis β-Carbonic Anhydrases. [PDF]

Sci Rep
Manaithiya A, Bhowmik R, Ray R, Merabti A, Richeter S, Carta F, Supuran CT, Clément S, Winum JY, Aspatwar A.   +9 more
europepmc   +1 more source