Results 161 to 170 of about 47,659 (268)

Synthesis and Characterization of Sulfonamide‐Schiff Bases, and Investigation of Cytotoxic, Antioxidant, HDAC, and Apoptotic Activities in Human Colon Cancer Cells (DLD‐1 and HT‐29)

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
New sulfonamide‐Schiff bases were synthesized, characterized, and investigated for their cytotoxic, antioxidant, HDAC, and apoptotic activities in human colon cancer cells (DLD‐1 and HT‐29). Compounds 3c and 3d emerged as promising candidates to act as selective therapeutic agents by targeting the p38/MAPK‐ERK1 pathway in colorectal cancer.
Seda Mesci, Berna Kocaman, Aliye Gediz Erturk, Emine Bagdatli, Burak Yazgan, Tuba Yildirim   +5 more
wiley   +1 more source

Topiramate‐induced acute angle closure with suprachoroidal effusion: Insights from a novel ultra‐wide‐field OCT device

Acta Ophthalmologica, Volume 104, Issue 3, Page e356-e359, May 2026.
Michael Hafner, Nicolas Pensel, Nicolas C. D. Scherer, Marc J. Mackert, Siegfried G. Priglinger, Leonie F. Keidel, Maximilian J. Gerhardt   +6 more
wiley   +1 more source

Effects of Supramolecular Interactions on E/Z‐Isomerizations in Water and Their Importance for Biological Applications

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
Biomimetic supramolecular hosts in water affect outcomes and behavior of E/Z‐isomerizations. A deeper understanding of such effects can pave the way to understanding photochemical processes in more complex biological environments. The review displays examples of supramolecular hosts affecting the outcomes of E/Z‐isomerizations and subsequently ...
Doğan Akbulut, Gianna Pölderl, Line Næsborg   +2 more
wiley   +1 more source

Case Report: Carbonic anhydrase inhibitor brinzolamide dramatically improved the morphology and also function of a patient with RS1 mutation. [PDF]

Front Pharmacol
Ren Y, Liu S, Rong J, Wang D, Diao M, Zhang Y, Tian S, Shang M, Song C, Guan Y, Wang Z, Pang J.   +11 more
europepmc   +1 more source

Adaptive and Biochemical Responses of Dictyosphaerium sp. AM‐2024a to Environmental Conditions and Microplastic Interactions: Synergy of Biofuel Production With Pollution Mitigation

Biotechnology and Applied Biochemistry, Volume 73, Issue 2, Page 768-781, April 2026.
ABSTRACT This study investigates the physiological and biochemical responses of a newly isolated microalgal strain, Dictyosphaerium sp. AM‐2024a, identified through 18S rDNA sequencing, under varying environmental conditions and microplastic (MP) interactions.
Khushboo Iqbal, Arti Mishra, Smitha Mony Sreedharan   +2 more
wiley   +1 more source

A novel sulfamoylphenyl-dihydro-thiadiazole derivative as a dual EGFR and carbonic anhydrase inhibitor for cancer therapy. [PDF]

PLoS One
Eissa IH, Elkady H, Elgammal WE, Mahdy HA, Husein DZ, Amin FG, Elsheshiny AAA, Abdelfattah SS, Alsfouk AA, Elkaeed EB, Metwaly AM.   +10 more
europepmc   +1 more source

Use of Computational Models to Investigate Human Targets of Small Ubiquitous Molecules

ChemBioChem, Volume 27, Issue 8, April 2026.
Chemoinformatics and atomistic modeling were combined to identify protein targets of environmentally and occupationally relevant chemical compounds. A public database linking chemicals, genes, phenotypes, and diseases was used for validation. The study highlights the potential and limitations of these fast, low‐cost computational approaches for early ...
Elena Frasnetti, Francesco Frigerio, Fabrizio Cinquini, Stefano A. Serapian, Silvia Pavoni, Giorgio Colombo   +5 more
wiley   +1 more source

An ureido-substituted benzenesulfonamide carbonic anhydrase inhibitor exerts a potent antitumor effect in vitro and in vivo. [PDF]

Exp Hematol Oncol
Gazzaroli G, Tavani C, Filiberti S, Massardi ML, Turati M, Garattini G, Peat TS, Pieraccini G, Angeli A, Supuran CT, Carta F, Giacomini A, Ronca R.   +12 more
europepmc   +1 more source

Carbon Dioxide‐Mediated Chemical Processes in Aqueous Solutions

Chemistry – A European Journal, Volume 32, Issue 13, 1 April 2026.
CO2 in water operates as a tunable electrophilic switch, inducing reversible pH and ion speciation changes that modulate nucleophilic reactivity and soft‐matter structure, influencing material properties. This Perspective highlights how CO2‐responsive aqueous systems and smart polymers enable controllable reactions, separations, and capture processes ...
Betty A. Kustiana, Anand Sharadha‐Ravi Ayyar, Adam J. Sowers, Adedeji Adebukola Adelodun, Margarita Poderyte, Ji‐Woong Lee   +5 more
wiley   +1 more source

Bacterial Carbonic Anhydrase Inhibitor CAI0019 Demonstrates Efficacy in <i><i>Enterococcus faecium</i></i> Septicemic Peritonitis Mouse Model While Sparing the Microbiome. [PDF]

ACS Infect Dis
Abutaleb NS, Holly KJ, Metcalfe CK, Abouelkhair AA, Tharra PR, Shrinidhi A, Abdelsattar AS, Burgo V, Melotte G, Akin-Olabiyi T, Knoblauch S, Ramaswamy R, Woodson C, Thirumalaikumar VP, Rodriguez JA, Yeo FJ, Snell OC, Nocentini A, Sundararajan A, Olson MR, Supuran CT, Seleem MN, Flaherty DP.   +22 more
europepmc   +1 more source