Results 181 to 190 of about 47,659 (268)

Sex‐specific elevated incidence of glaucoma associated with topiramate versus valproate or lamotrigine in epilepsy, not migraine: A population‐based cohort study

open access: yesEpilepsia, Volume 67, Issue 4, Page 1690-1702, April 2026.
Abstract Objective Topiramate has been linked to increased glaucoma risk, potentially through mechanisms involving ocular fluid shifts. However, comparative risks vs other antiseizure medications (ASMs) and variation by sex or indication remain uncertain.
Cuiling Wei   +10 more
wiley   +1 more source

Sialidosis type I: How to alleviate disabling myoclonic seizures?—A multicenter analysis of eight cases and review of the literature

open access: yesEpilepsia Open, Volume 11, Issue 2, Page 577-591, April 2026.
Abstract Objective Sialidosis type I (ST‐1) is an autosomal‐recessive, very rare, progressive lysosomal storage disorder caused by pathogenic variants in NEU1. It is clinically characterized by progressive ataxia, myoclonic seizures (MS), bilateral tonic–clonic seizures (BTCS), and distinctive ophthalmological findings.
Janina Gburek‐Augustat   +15 more
wiley   +1 more source

Phytochemical Diversity, Nutritional Values, and Biological Properties of Halopithys incurva (Hudson) Batters, 1902

open access: yesFood Science &Nutrition, Volume 14, Issue 4, April 2026.
Halopithys incurva is a red macroalga distributed across the Mediterranean Sea and North‐East Atlantic, with occasional reports from the Indian Ocean. It exhibits a rich chemical diversity, including isoflavones, bromophenols, MAAs, pigments, phycobiliproteins, primary metabolites, and neuroactive compounds.
Youssra Aalilou   +9 more
wiley   +1 more source

Preinfusion risk factors for the development of severe neurotoxicity following CART therapy in pediatric patients

open access: yesHemaSphere, Volume 10, Issue 4, April 2026.
Abstract Neurotoxicity is a common and potentially life‐threatening complication after chimeric antigen receptor T‐cell therapy (CART) for pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). The only consistently demonstrated clinical risk factor for severe neurotoxicity in prior studies is high, preinfusion bone marrow disease burden (DB).
Caroline Diorio   +18 more
wiley   +1 more source

A microRNA expression signature in infant t(4;11) KMT2A::AFF1+ BCP‐ALL uncovers novel therapeutic targets

open access: yesHemaSphere, Volume 10, Issue 4, April 2026.
Abstract Infants and children with KMT2A::AFF1+ leukemia have a dismal prognosis and are therefore in urgent need for more efficient and less aggressive therapy. In this study, we investigated three microRNAs that are downregulated in KMT2A::AFF1+ B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL): miR‐194, miR‐99b, and miR‐125a‐5p.
Camille Malouf   +13 more
wiley   +1 more source

Carbonic anhydrase inhibitors:

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2013
Derya Ekinci   +4 more
openaire   +1 more source

Population Pharmacokinetic Modeling of Intravenous Topiramate in Patients with Epilepsy or Migraine

open access: yesThe Journal of Clinical Pharmacology, Volume 66, Issue 4, April 2026.
Abstract Topiramate (TPM) is approved for seizures and migraine prophylaxis and is used off‐label for several neuropsychiatric conditions. The available dosage forms, including tablets and sprinkle capsules, are unsuitable for patients who may be unable to take medicine orally.
Adeboye O. Bamgboye   +7 more
wiley   +1 more source

Proteomic Profiling of Human Extracellular Vesicles Reveals Diagnostic Biomarkers for Colon Adenocarcinoma

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
Proteomic profiling of tissue explant‐ and plasma‐derived extracellular vesicles identified colon adenocarcinoma‐associated and healthy‐associated EV proteins. A 10‐protein EV panel enabled highly sensitive blood‐based detection of colon adenocarcinoma, showed marked postoperative changes, and retained performance in an independent validation cohort ...
Yura Seo   +33 more
wiley   +1 more source

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