Results 191 to 200 of about 25,630 (237)
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Carborane‐Based Carbonic Anhydrase Inhibitors
Angewandte Chemie International Edition, 2013CA inhibitors: Human carbonic anhydrases (CAs) are diagnostic and therapeutic targets. Various carborane cages are shown to act as active-site-directed inhibitors, and substitution with a sulfamide group and other substituents leads to compounds with high selectivity towards the cancer-specific isozyme IX.
Brynda, J. (Jiří) +8 more
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Safety of carbonic anhydrase inhibitors
Expert Opinion on Drug Safety, 2014Carbonic anhydrase (CA) inhibitors have an impressive safety record despite the multiple functions that CA isozymes serve because they are not fully inhibited with most dosing. While reducing the targeted CA-dependent process sufficiently for disease control, residual activity and uncatalyzed rates in combination with compensations are adequate to ...
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Carbonic Anhydrase Inhibitors as Anticonvulsant Agents
Current Topics in Medicinal Chemistry, 2007Seizures are one of the most common neurological disorders in clinical medicine. Triggering mechanisms by which seizures form remain unclear, but are related to a rapid change in ionic composition, including an increase of intracellular potassium concentration and pH shifts within the brain.
A. Thiry +3 more
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Nature, 1967
CARBONIC anhydrase is present in the frog gastric mucosa and fish gill which actively transport chloride, and it has been observed that carbonic anhydrase inhibitors of the sulphonamide type decrease net chloride active transport in these tissues1,2. Zadunaisky3 has reported that chloride is actively transported by the frog cornea, and 95–100 per cent ...
S, Kitahara, K R, Fox, C A, Hogben
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CARBONIC anhydrase is present in the frog gastric mucosa and fish gill which actively transport chloride, and it has been observed that carbonic anhydrase inhibitors of the sulphonamide type decrease net chloride active transport in these tissues1,2. Zadunaisky3 has reported that chloride is actively transported by the frog cornea, and 95–100 per cent ...
S, Kitahara, K R, Fox, C A, Hogben
openaire +2 more sources
1985
Inhibitors of carbonic anhydrase presently have a limited role in the treatment of epilepsy. Inorganic anions, such as I−, CN−, SH−, CNO−, SCN−, and Br−, and sulfonamides are inhibitors of the enzyme carbonic anhydrase (Maren 1967). Both bromides and sulfonamides have been used in the treatment of epilepsy in man.
J. E. Riggs, R. C. Griggs
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Inhibitors of carbonic anhydrase presently have a limited role in the treatment of epilepsy. Inorganic anions, such as I−, CN−, SH−, CNO−, SCN−, and Br−, and sulfonamides are inhibitors of the enzyme carbonic anhydrase (Maren 1967). Both bromides and sulfonamides have been used in the treatment of epilepsy in man.
J. E. Riggs, R. C. Griggs
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Glaucoma and the Applications of Carbonic Anhydrase Inhibitors
2013Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) has pharmacologic applications in the treatment of glaucoma, a disease affecting a large number of people and characterized by an elevated intraocular pressure (IOP). At least three isoforms, CA II, IV and XII are targeted by the sulfonamide inhibitors, some of which are clinically used drugs ...
SCOZZAFAVA, ANDREA +1 more
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