Results 201 to 210 of about 47,659 (268)

ZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH [PDF]

, 2015

core   +1 more source

OSA Endotyping as Targets for Treatment. How Far Have We Come?

Respirology, Volume 31, Issue 4, Page 339-351, April 2026.
ABSTRACT Obstructive sleep apnoea (OSA) is highly prevalent and is associated with significant impairments in quality of life and comorbidity. The most common treatment employed is continuous positive airway pressure (CPAP), especially in moderate and severe cases.
Walter T. McNicholas, Sara Op de Beeck, Pasquale Tondo, Johan Verbraecken, Maria R. Bonsignore   +4 more
wiley   +1 more source

Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice. [PDF]

Int J Mol Sci, 2017
Noma N, Fujii G, Miyamoto S, Komiya M, Nakanishi R, Shimura M, Tanuma SI, Mutoh M.   +7 more
europepmc   +1 more source

pH‐Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid–base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal ...
Albrecht Schwab, Micol Rugi, Pawel Swietach, Wiktoria Błaszczak, Ivana Novak, Ganga Deshar, Stine Falsig Pedersen, Renata Ialchina, Albin Sandelin, Jiayi Yao, Stephan J. Reshkin, Rosa A. Cardone, Tiago M. A. Carvalho, Annarosa Arcangeli, Rayhana Bouazzi, Franco N. D'Alessandro, Natalia Prevarskaya, Madelaine M. Audero, Halima Ouadid‐Ahidouch, Julie Schnipper, Luis A. Pardo, Xiaoyi Shi, Frauke Alves, Jakub Mitręga, Anna Trauzold, Sofie E. Hagelund, György Panyi, Marco Cozzolino, Clemens M. W. G. Löwik, Laura Mezzanotte, Roisin McMorrow, Andreas Pahl, Torsten Hechler, Elena Papacharisi, Alessandra Fiorio Pla, Ildiko Szabo, Verena Hofschröer, Zoltán Pethő   +37 more
wiley   +1 more source

Synthesis, Bioactivity and Molecular Modeling Studies on Benzimidazole Derivatives and Its Isosteres as Potent AChE/BChE and GSK3β Inhibitors for Alzheimer's Disease

Chemical Biology &Drug Design, Volume 107, Issue 4, April 2026.
Compounds 1j, 1l, 2b, 2j, 3g, and 3l were found to have potent anti‐Alzheimer agents for AChE, BChE inhibitions, neuroprotective effects in the presence of H2O2 and GSK3β inhibitions. ABSTRACT A series of benzimidazoles and its analogs (benzoxazoles and benzothiazoles) bearing a benzohydrazide‐hydrazones moiety at the 2‐position were designed and ...
Gözde Sayar, Sulunay Parlar, Ayse Hande Tarikogullari, Mumin Alper Erdoğan, Guliz Armagan, Vildan Alptuzun   +5 more
wiley   +1 more source

Update on diagnosis, nonpharmacological treatment and prevention of Equine Gastric Ulcer Syndrome (EGUS)

Equine Veterinary Education, Volume 38, Issue 4, Page 206-219, April 2026.
Summary The term Equine Gastric Ulcer Syndrome (EGUS) has been used since 1999. As there are important differences, the terms Equine Squamous Gastric Disease (ESGD) and Equine Glandular Gastric Disease (EGGD) were introduced in 2015. Risk factors like dietary management, training regimens and drug side effects, as described for NSAIDs, predispose ...
R. Lensing, A. K. Barton
wiley   +1 more source

Trefoil Factor‐3 Is a Hypoxia‐Triggered Pro‐Tumorigenic Factor in Hepatoblastoma

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Background & Aims Hepatoblastoma (HB) is the most common malignant liver tumour in children. Despite improved survival in low‐risk disease, outcomes for advanced or relapsed HB remain poor, emphasising the need for new therapeutic targets.
Luz A. Martínez‐Pérez, M. Ujue Latasa, Iker Uriarte, Amaya López‐Pascual, Jasmin Elurbide, Pavel Strnad, Sona Frankova, Eva Sticova, Ondrej Fabian, Maria Arechederra, Eva Santamaria, Josepmaria Argemi, Bruno Sangro, Beatrice Foglia, Maurizio Parola, Melva Gutiérrez‐Angulo, Stefano Cairo, Ramón Bataller, Pau Sancho‐Bru, Maria L. Martinez‐Chantar, Jose J. G. Marin, Andrea Castaneda, Carolina Armengol, Carmen Berasain, Maite G. Fernandez‐Barrena, Matias A. Ávila   +25 more
wiley   +1 more source

X-ray analysis of complexes of carbonic anhydrase II with 1,3-oxazole-containing sulfonamide derivatives elucidates the structural basis for their exceptionally high inhibitory potency. [PDF]

Acta Crystallogr F Struct Biol Commun
Stoliarskaia MY, Borisevich SS, Myaskov EO, Shetnev AA, Korsakov MK, Nikonov OS.   +5 more
europepmc   +1 more source

Multi‐proteomic profiling indicates potential regulatory signatures underlying rice resistance to Magnaporthe oryzae

The Plant Journal, Volume 126, Issue 2, April 2026.
SUMMARY Omics‐driven approaches can capture systemic plant responses to pathogens. While transcriptomics is a mainstay, it alone cannot capture post‐translational modifications or protein abundance. Because of this, we employed multi‐proteomics to compare the proteome, phosphoproteome, and acetylome of two rice genotypes differing in resistance to ...
Priscila A Auler, Christian Montes‐Serey, Luis W. P. Arge, Gaoyuan Song, Justin Walley, Marcio C. Silva‐Filho   +5 more
wiley   +1 more source

Neuroprotective and Renoprotective Potential of a Hydroethanolic Extract From the Aerial Parts of Mattiastrum paphlagonicum Bornm. (Boraginaceae). [PDF]

Chem Biodivers
Kayabaş Avşar A, Büker E, Yildirim E, Casoni D, Cobzac SCA.   +4 more
europepmc   +1 more source