Results 121 to 130 of about 695,880 (253)

Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII)

, 2015
Carbonic anhydrases (CAs) are widespread metalloenzymes in higher vertebrates including humans. A series of phenolic compounds, including guaiacol, 4-methylguaiacol, 4-propylguaiacol, eugenol, isoeugenol, vanillin, syringaldehyde, catechol, 3-methyl ...
Passaponti, Maurizio, SUPURAN, Claudiu T., GÜLÇİN, İlhami, Scozzafava, Andrea   +3 more
core   +1 more source

Ocular mucous membrane pemphigoid: A retrospective study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Neda Cramer, Johannes Mohr, Rotraut Mössner, Christian van van Oterendorp   +3 more
wiley   +1 more source

Micropulse transscleral cyclophotocoagulation in canine glaucoma: A retrospective study evaluating sweep velocity

Veterinary Ophthalmology, Volume 28, Issue 2, Page 293-305, March 2025.
Abstract Objective To report preliminary results of MP‐TSCP in canine patients with glaucoma while evaluating sweep velocity, treatment efficacy, and safety utilizing standardized surgical parameters. Animal studied Client‐owned dogs that underwent MP‐TSCP at a veterinary referral hospital. Procedure Medical records of 19 eyes (14 dogs) treated with MP‐
Valeria Benitez‐Vera, Dineli Bras, Fabiano Montiani‐Ferreira   +2 more
wiley   +1 more source

Intermittent hypoxia interventions for inducing ventilatory acclimatization to high altitude?

Experimental Physiology, EarlyView.
Abstract Accumulation of ∼200 h of hypoxia exposure (pre‐acclimatization) has been suggested to prevent the development of acute mountain sickness when a person is subsequently exposed to high altitude. These pre‐exposures are typically undertaken intermittently at or near the place of residence, primarily during sleep in hypoxic tents, and are likely ...
Martin Burtscher, Axel Kleinsasser, Johannes Burtscher, Katharina Hüfner, Erik R. Swenson, Peter Hackett, Hannes Gatterer   +6 more
wiley   +1 more source

Benzenesulfonamide decorated dihydropyrimidin(thi)ones: carbonic anhydrase profiling and antiproliferative activity [PDF]

<jats:p>One-step synthesis and a chemical similarity-based screening provide new tumor-associated carbonic anhydrase (CA) inhibitors for anticancer application.</jats:p ...
Governa, Paolo, carta, fabrizio, TAVANI, CAMILLA, angeli, andrea, Supuran, Claudiu T., D'Agostino, Ilaria, RONCA, Roberto, Manetti, Fabrizio, Renzi, Gioele, Carradori, Simone, massardi, Maria luisa, Supuran, Claudiu, Ferraroni, Marta, ASLAN, Hakan   +13 more
core   +1 more source

Mechanism of Pingchuanning in Attenuating Asthma Based on UHPLC‐Q‐Orbitrap HRMS and Network Pharmacology Analysis

Biomedical Chromatography, Volume 40, Issue 12, December 2026.
ABSTRACT An ultrahigh‐performance liquid chromatography coupled with quadrupole‐Orbitrap high‐resolution mass spectrometry (UHPLC‐Q‐Orbitrap HRMS) method was applied to characterize Pingchuanning (PCN) decoction and its absorbed serum constituents in asthmatic rats.
Yue Zhang, Yiwen Ding, Weidong Chen, Yuanbo Bi, Yanyan Wang, Weidong Ye, Xiangming Fang   +6 more
wiley   +1 more source

Treat Ankylosing Spondylitis with Methazolamide

International Journal of Medical Sciences, 2011
Background: Increased bone resorption and new bone information are two characteristics of ankylosing spondylitis (AS). Much evidence has shown that carbonic anhydrase inhibitors can restrain bone resorption.
Xiaotian Chang, Xinfeng Yan, Yunzhong Zhang
doaj  

A CRITICAL EVALUATION OF THE HISTOCHEMICAL METHODS FOR CARBONIC ANHYDRASE

, 1972
The histochemical methods for carbonic anhydrase are not based on the postulated dehydration of HCO3–. The staining is caused by the formation of an unknown reactive Co compound in the surface layer secondary to enzyme-independent alkalinization of the ...
THOMAS F. MUTHER
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, Volume 20, Issue 11, Page 2918-2935, November 2026.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Inhibitory, Anticancer Efficacy and Structural Insights of a Novel Ethyl 1‐Hydroxy‐3‐Oxo‐1‐Phenylisoindoline‐2‐Sulfonate Compound Selectively Targeting Human CA IX and CA XII Carbonic Anhydrase, Ferroptosis‐Mediated Cell Death

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Carbonic anhydrase (CA) isoforms IX and XII are critical in anticancer drug development due to their essential roles in regulating pH and hypoxic conditions. In this study, the inhibitory potential of ethyl‐1‐hydroxy‐3‐oxo‐1‐phenylisoindoline‐2‐sulfonate (1), synthesized via click chemistry, was evaluated against hCA IX and hCA XII.
Funda Keteci, Songul Bayrak, Ufuk Atmaca, Mustafa Özkaraca, Azada Aliyeva, Buket Bakan   +5 more
wiley   +1 more source