Results 111 to 120 of about 648,149 (287)

Use of inhibitors in physiological studies of carbonic anhydrase

, 1977
The appropriate use of acetazolamide in examining physiological function is based on the following: 1) the dissociation constant of the drug-carbonic anhydrase complex (10(-8) M); 2) the concentration needed to eliminate the catalyzed reaction (10(-4) M
T. H. Maren
core   +1 more source

Out of the active site binding pocket for carbonic anhydrase inhibitors

, 2015
A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this ...
De Simone, G., CARRADORI, Simone, Supuran, Ct, Secci, D, D'Ambrosio, K, Monti, Sm, Vullo, D, Buonanno, M   +7 more
core   +2 more sources

Exploring the binding potential of natural compounds to carbonic anhydrase of cyanobacteria through computer-based simulations

Discover Applied Sciences
Cyanobacteria in water bodies cause harmful cyanobacterial blooms, releasing toxins that degrade water quality and cause health issues. Common Harmful Algal Bloom-related disorders (HABs) include neurotoxic shellfish poisoning, ciguatera poisoning ...
Archana Padhiary, Showkat Ahmad Mir, Aiswarya Pati, Binata Nayak   +3 more
doaj   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Affinity to some inhibitors of human carbonic anhydrase-1 and bovine carbonic anhydrase

, 1996
The carbonic anhydrase Isoenzymes employed here have been purifield in high yields by affinity chromatograpy using different affinity gels(Sepharose4B-L-tyrosine-Benzensulfonamide).
Kufrevioglu, OI, ARSLAN, O
core   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source

Structure-based drug design of novel inhibitors of carbonic anhydrase for treatment of glaucoma

, 2009
In humans, there are twelve carbonic anhydrase (CA) isozymes that possess catalytic activity for the reversible hydration of carbon dioxide. Carbonic anhydrases (CAs) underpin crucial physiological and pathological processes and are thus pharmaceutical ...
Singer, Mathilde, Hofmann, Andreas, Lopez, Marie, Paul, Blessy, Poulsen, Sally-Ann   +4 more
core  

Activity of carbonic anhydrase inhibitors in breast cancer models. [PDF]

, 2016
Evaluation of carbonic anhydrase inhibitors activity in breast cancer 2D and 3D ...
Želvytė, Aušra,
core  

(Z)-N-(3-([1,1'-biphenyl]-2-yl)-4-heptyl-4-hydroxythiazolidin-2-ylidene)-4-bromobenzamide as carbonic anhydrase inhibitor: exploration of its in vitro and in silico studies

BMC Chemistry
Human Carbonic Anhydrase inhibitors (CAIs) have been clinically used to treat a variety of disorders, such as cancer, obesity, haemolytic anaemia, glaucoma, retinopathy, and epilepsy.
Aftab Ahmed, Sara Ilyas, Pervaiz Ali Channar, Syeda Abida Ejaz, Aamer Saeed, Seema Sarwar Ghumro, Mohamad Ahmad Saleem Khasawneh, Shagufta Naz Channar, Rabail Ujan, Qamar Abbas, Tuncer Hökelek   +10 more
doaj   +1 more source

Microarrayed Allergen Molecules Distinguish IgE Sensitisation to Blomia tropicalis and Dermatophagoides pteronyssinus

Allergy, EarlyView.
This study established a microarray containing a representative panel of purified Blo t and Der p allergens for the identification of patients sensitised to Blo t and/or Der p. Results indicate that the microarray based on Blo t and Der p allergens is a useful tool for the identification of Blo t‐ and/or Der p‐sensitised patients. The microarray may be
Nishelle Dsouza, Siratcha Phanthong, Huey‐Jy Huang, Milena Weber, Eszter Sarzsinszky, Petra Zieglmayer, Gabrielle Pauli, Margarete Focke‐Tejkl, Mikhail Tulaev, Nikolina Todorovic, Walter Keller, Thomas Schlederer, Luis Caraballo, Anchalee Tungtrongchitr, Rudolf Valenta, Pongsakorn Tantilipikorn, Susanne Vrtala   +16 more
wiley   +1 more source