Results 111 to 120 of about 42,053 (258)

Movement Disorders in Developmental and Epileptic Encephalopathies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Monogenic developmental and epileptic encephalopathies (DEE) frequently feature co‐occurring movement disorders. Gene discovery has expanded epilepsy‐dyskinesia syndromes (EDS) from classic associations such as stereotypies in Rett syndrome to PRRT2‐related infantile seizures with paroxysmal dyskinesia and crouched gait in SCN1A ...
Shekeeb Mohammad, Darius Ebrahimi‐Fakhari, Hugo Morales‐Briceno   +2 more
wiley   +1 more source

Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia [PDF]

, 2013
<p>Background Comparative analysis of tissue-specific transcriptomes is a powerful technique to uncover tissue functions. Our FlyAtlas.org provides authoritative gene expression levels for multiple tissues of Drosophila melanogaster (1).
Chintapalli, V.R., Davies, S.A., Dow, J.A.T., Herzyk, P., Wang, J.   +4 more
core   +2 more sources

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors

Molecules, 2016
Phenols are among the largest and most widely distributed groups of secondary metabolites within the plant kingdom. They are implicated in multiple and essential physiological functions.
Anastasia Karioti, Fabrizio Carta, Claudiu T. Supuran   +2 more
doaj   +1 more source

An overview of carbohydrate-based carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Carbonic anhydrases (CAs) are metalloenzymes responsible for the reversible hydration of carbon dioxide to bicarbonate, a fundamental reaction involved in various physiological and pathological processes.
Doretta Cuffaro, Elisa Nuti, Armando Rossello   +2 more
doaj   +1 more source

Current Knowledge and Attitudes Concerning Cost-Effectiveness in Glaucoma Pharmacotherapy: A Glaucoma Specialists Focus Group Study. [PDF]

, 2020
Background:Rising healthcare costs motivate continued cost-reduction efforts. To help lower costs associated with open-angle glaucoma (OAG), a prevalent, progressive disease with substantial direct and indirect costs, clinicians need to understand the ...
Cioffi, George A, Feldman, Robert M, Feldman, Robert M, Liebmann, Jeffrey M, Weinreb, Robert N   +4 more
core  

Measuring Binding of Protein to Gel-Bound Ligands Using Magnetic Levitation [PDF]

, 2012
This paper describes the use of magnetic levitation (MagLev) to measure the association of proteins and ligands. The method starts with diamagnetic gel beads that are functionalized covalently with small molecules (putative ligands).
Mace, Charles R., Mirica, Katherine A., Phillips, Scott T., Shapiro, Nathan D., Shevkoplyas, Sergey S., Soh, Siowling, Taran, Olga, Whitesides, George M.   +7 more
core   +2 more sources

Parallel Analysis of Acidic and Basic Proteoforms in Cell Lysates via Native Cation and Anion Exchange Chromatography—Native Mass Spectrometry

PROTEOMICS, EarlyView.
ABSTRACT Comprehensive characterization of proteoforms in complex biological systems remains a significant challenge. While native ion‐exchange chromatography (IEC) hyphenated with native mass spectrometry (nMS) is a powerful tool for resolving proteoforms, three critical limitations persist: restricted volatile buffers causing nonlinear pH gradients ...
Ziran Zhai, Hafsa Zakri, Matteo Damian, Francesco G. Mutti, Garry Corthals, Andrea F. G. Gargano   +5 more
wiley   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

Evaluation of Benzenesulfonamide Derivatives; Quinazoline and Sulfonamide Selectively Targeting Carbonic Anhydrase XII for Tumor Microenvironment Modulation in Human Breast Cancer Cells

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Tumor cells evolve adaptive mechanisms to function optimally within an acidic microenvironment. This adaptation is driven by the enhanced metabolic activity of tumors, which frequently results in acidosis and hypoxia.
HIBA NABIL MIRAN, GHAITH ALI JASIM, TAREQ HAFDHI ABIDTAWFEEQ, AMMAR A. IBRAHIM AL-AZZAWI   +3 more
doaj   +1 more source