Results 111 to 120 of about 695,880 (253)

Discovery of Strecker-type α-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry

, 2017
A new type of carbonic anhydrase inhibitors was identified via differential scanning fluorimetry (DSF) screening. The compounds displayed interesting inhibition profile against human carbonic anhydrase isoforms I, II, IX and XII with an obvious ...
Mikhail Krasavin (820851), Roman Stavniichuk (2563918), Petro Borysko (2563921), Claudiu T. Supuran (24658), Sergey Zozulya (26170), Daniela Vullo (818130)   +5 more
core   +1 more source

From productive coupling to catalytic commitment: An evolutionarily tuned interdomain connector in Leishmania Aha1 orchestrates Hsp90 activation

The FEBS Journal, EarlyView.
LbAha1 activates LbHsp90 through a multistep mechanism in which productive N‐domain docking precedes ATP‐driven rearrangement and linker ordering. The LbAha1 linker transitions from a flexible to helical state, stabilizing an asymmetric, catalytically competent closed complex.
Paulo Roberto Dores‐Silva, Thiago Vargas Seraphim, Karine Minari, Izabella Rodrigues Fonseca da Silva, Winston Pinheiro Claro Gomes, Leijiane Figueira de Sousa, Arthur Moraes Franco da Rocha, Leandro Ramos Souza Barbosa, Jeremiah Stanson Joseph, Júlio César Borges   +9 more
wiley   +1 more source

Optic nerve oxygen tension in pigs and the effect of carbonic anhydrase inhibitors

, 1999
To evaluate how the oxygen tension of the optic nerve (ONP(O)2) is affected by the administration of the carbonic anhydrase inhibitors dorzolamide and acetazolamide and by alterations in oxygen and carbon dioxide in the breathing ...
Bang, K, Stefánsson, E, Jensen, P K, Eysteinsson, T, Dollerup, J, la Cour, M, Kiilgaard, Jens Folke, Scherfig, E   +7 more
core   +1 more source

Rational drug design: Binding free energy differences of carbonic anhydrase inhibitors

, 1989
The free energy perturbation method has been applied to calculate the binding energy of sulphonamide inhibitors to carbonic anhydrase; the agreement with experiment gives further evidence for the reliability of this method even for anionic inhibitors and
C. A. Reynolds, W. G. Richards, MENZIANI, Maria Cristina   +2 more
core   +1 more source

A novel rare splice variant of the human voltage‐dependent proton channel hHV1

The FEBS Journal, EarlyView.
Alternative splicing of the human HVCN1 gene produces a rare, very‐long proton channel isoform (hHV1‐vl) containing an additional 47 amino acids at its N terminus. This variant was detected in human tissues, including choroid plexus epithelial cells and lymphomas. Compared with the conventional long isoform (hHV1‐l), hHV1‐vl activates more slowly while
Gustavo Chaves, Karl‐Matthäus C. Herold, Christian Derst, Christophe Jardin, Iryna Mahorivska, Carolin S. Jäger, Arne Franzen, Boris Musset   +7 more
wiley   +1 more source

Finding the sweet spot: An exploration of environmental factors to optimize Ulva carbohydrate content and composition

Journal of Phycology, EarlyView.
Abstract Green macroalgae from the Ulva genus are rich in polysaccharides of interest, including ulvan, starch, and cellulose. However, their content and structure are impacted by environmental factors, which poses challenges for industrial applications, especially in the context of climate change.
Julie Grivotte, Zoë A. Popper
wiley   +1 more source

Carbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vessels

, 2005
Carbonic anhydrase inhibitors (CAIs) increase blood flow in the brain and probably also in the optic nerve and retina. Additionally they elevate the oxygen tension in the optic nerve in the pig.
Stefánsson, Einar, Pedersen, Daniella Bach, Bang, Kurt, Eysteinsson, Thor, la Cour, Morten, Kiilgaard, Jens Folke, Wiencke, Anne Kathrine, Koch Jensen, Peter   +7 more
core   +1 more source

Embryonal degreening and seed longevity require plastid LEA proteins

New Phytologist, EarlyView.
Working model of how plastidial LEA proteins aid the remodelling of photosynthetic structures during degreening of Arabidopsis seed embryos. LEA42 and LEA48 support thylakoid proteostasis and membrane remodelling in embryonal cells during late seed maturation by maintaining a local physicochemical environment compatible with protein turnover and ...
Dennis Brandt, Ana Carolina Vilchez, Jürgen Eirich, Paulina Heinkow, Lea Hembach, Ke Zheng, Pedro Barreto, Jan‐Ole Niemeier, Lando Lebok, Ivo Feussner, Felix Buchert, Alexey Amunts, Kristina Kühn, David Macherel, Till Ischebeck, Michael Melzer, Iris Finkemeier, Markus Schwarzländer   +17 more
wiley   +1 more source

Time‐series multi‐omics analysis of micronutrient stress in Sorghum bicolor reveals iron and zinc crosstalk and regulatory network conservation

Plant Biology, EarlyView.
Overlap between Fe and Zn responsive gene regulatory networks (GRNs) were found, indicative of micronutrient crosstalk, and conservation of root and leaf GRNs and genes suggests strong constraint on homeostasis networks in plants. Abstract Micronutrient stress impacts growth, biomass production, and grain yield in crops.
A. Mishra, A. Bhat, S. Kumari, R. Sharma, J. Braynen, D. Tadesse, S. El Alaoui, S. Seaver, N. Grosjean, D. Ware, M. Xie, T. Paape   +11 more
wiley   +1 more source

Vision outcomes in dogs with primary glaucoma surgically treated with lensectomy and endolaser cyclophotocoagulation after an Ahmed valve gonioimplantation failure

Veterinary Ophthalmology, Volume 28, Issue 2, Page 207-217, March 2025.
Abstract Objective The aim of this study was to retrospectively evaluate vision outcomes of dogs with primary angle closure glaucoma (PACG) that underwent Ahmed valve gonioimplantation (AVG) followed by lensectomy and endolaser cyclophotocoagulation (ECP) with or without bleb resection after AVG failure.
Bactelius Turicea, Christian L. Munevar, Sydney G. Edwards, Lana L. Linton   +3 more
wiley   +1 more source