Results 101 to 110 of about 23,970 (278)

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Human Carbonic Anhydrase Inhibitors

ACS Medicinal Chemistry Letters
Humans encode 15 isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), which catalyzes the interconversion between CO2 and bicarbonate and is involved in a multitude of physiological/pathological processes. CA inhibitors are in clinical use as diuretics, anti-glaucoma drugs, anti-epileptics, and anti-obesity agents.
openaire   +2 more sources

Dexamethasone implant versus topical carbonic anhydrase inhibitors in patients with bilateral retinitis pigmentosa–related cystoid macular edema [PDF]

Purpose: To compare within-subject efficacy and safety of intravitreal dexamethasone implant and topical carbonic anhydrase inhibitors in the treatment of retinitis pigmentosa–related cystoid macular edema. Methods: Patients with bilateral retinitis
Colizzi, B., Autelitano, A., Montesano, G., Bertelli, M., Rossetti, L., Maltese, P., Colombo, L., Di Domenico, A., Rissotto, R.   +8 more
core   +1 more source

Parallel Analysis of Acidic and Basic Proteoforms in Cell Lysates via Native Cation and Anion Exchange Chromatography—Native Mass Spectrometry

PROTEOMICS, EarlyView.
ABSTRACT Comprehensive characterization of proteoforms in complex biological systems remains a significant challenge. While native ion‐exchange chromatography (IEC) hyphenated with native mass spectrometry (nMS) is a powerful tool for resolving proteoforms, three critical limitations persist: restricted volatile buffers causing nonlinear pH gradients ...
Ziran Zhai, Hafsa Zakri, Matteo Damian, Francesco G. Mutti, Garry Corthals, Andrea F. G. Gargano   +5 more
wiley   +1 more source

Exploring the binding potential of natural compounds to carbonic anhydrase of cyanobacteria through computer-based simulations

Discover Applied Sciences
Cyanobacteria in water bodies cause harmful cyanobacterial blooms, releasing toxins that degrade water quality and cause health issues. Common Harmful Algal Bloom-related disorders (HABs) include neurotoxic shellfish poisoning, ciguatera poisoning ...
Archana Padhiary, Showkat Ahmad Mir, Aiswarya Pati, Binata Nayak   +3 more
doaj   +1 more source

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, EarlyView.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

Discovery of Strecker-type α-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry

, 2017
A new type of carbonic anhydrase inhibitors was identified via differential scanning fluorimetry (DSF) screening. The compounds displayed interesting inhibition profile against human carbonic anhydrase isoforms I, II, IX and XII with an obvious ...
Mikhail Krasavin (820851), Roman Stavniichuk (2563918), Petro Borysko (2563921), Claudiu T. Supuran (24658), Sergey Zozulya (26170), Daniela Vullo (818130)   +5 more
core   +1 more source

DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity

Small, EarlyView.
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley   +1 more source

(Z)-N-(3-([1,1'-biphenyl]-2-yl)-4-heptyl-4-hydroxythiazolidin-2-ylidene)-4-bromobenzamide as carbonic anhydrase inhibitor: exploration of its in vitro and in silico studies

BMC Chemistry
Human Carbonic Anhydrase inhibitors (CAIs) have been clinically used to treat a variety of disorders, such as cancer, obesity, haemolytic anaemia, glaucoma, retinopathy, and epilepsy.
Aftab Ahmed, Sara Ilyas, Pervaiz Ali Channar, Syeda Abida Ejaz, Aamer Saeed, Seema Sarwar Ghumro, Mohamad Ahmad Saleem Khasawneh, Shagufta Naz Channar, Rabail Ujan, Qamar Abbas, Tuncer Hökelek   +10 more
doaj   +1 more source

Carbonic Anhydrase Inhibitors

Pratap Challa, David L. Epstein
openaire   +2 more sources