Results 81 to 90 of about 42,053 (258)

Carbonic anhydrase inhibitors: an editorial [PDF]

Expert Opinion on Therapeutic Patents, 2013
This issue of Expert Opinion on Therapeutic Patents is dedicated to carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs), a highly dynamic research topic in the last years. Several review articles and patent analyses on diuretics and antiglaucoma, antiepileptic, anti-obesity and anticancer agents belonging to the pharmacological class of the CAIs are ...
openaire   +2 more sources

Technobiological Pathways for High‐CO₂ Capture Using Micro‐/Macroalgae: Genetic Engineering, Process Automation, and Value‐Added Bioproducts

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Greenhouse gas (GHG) emissions have emerged as one of the most critical drivers of climate change; this is primarily due to high concentrations and long atmospheric life of carbon dioxide (CO2). For a significant amount of time, various biological processes such as microalgal cultivation, cyanobacterial systems, photosynthetic microorganisms ...
Sadhana Semwal, Harish Chandra Joshi
wiley   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Quantitative assessment of specific carbonic anhydrase inhibitors effect on hypoxic cells using electrical impedance assays

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Carbonic anhydrase IX (CA IX) is an important orchestrator of hypoxic tumour environment, associated with tumour progression, high incidence of metastasis and poor response to therapy.
Luciana Stanica, Mihaela Gheorghiu, Miruna Stan, Cristina Polonschii, Sorin David, Dumitru Bratu, Anca Dinischiotu, Claudiu T. Supuran, Eugen Gheorghiu   +8 more
doaj   +1 more source

ANIDRASI CARBONICA:SINTESI DI SOLFONAMMIDI BENZOTIOPIRANO-PIRIMIDINICHE QUALI POTENZIALI INIBITORI ISOFORMA SELETTIVI [PDF]

, 2015
Le anidrasi carboniche (CA) sono una superfamiglia di metallo-enzimi che catalizzano l’interconversione tra anidride carbonica e ione bicarbonato. Ad oggi sono conosciute cinque distinte famiglie genetiche di diversa evoluzione: α-CA, β-CA, γ-CA, δ-CA e ...
PESCAGLINI, SARA
core  

Major contribution of the type II beta carbonic anhydrase CanB (Cj0237) to the capnophilic growth phenotype of Campylobacter jejuni [PDF]

, 2016
Campylobacter jejuni, the leading cause of human bacterial gastroenteritis, requires low environmental oxygen and high carbon dioxide for optimum growth, but the molecular basis for the carbon dioxide requirement is unclear. One factor may be inefficient
Alazzam, Alber, Allos, Bolton, Bury-Moné, Capasso, Carta, Covarrubias, Cronk, Cronk, De Simone, Dugar, Eichler, Epps, Fernandez, Ferry, Fraser, Gai, Gaskin, Gibson, Gielda, Guccione, Guilloton, Gundogdu, Hani, Hermans, Hofreuter, Hofreuter, Hofreuter, Innocenti, Jitrapakdee, Kakuda, Kaur, Kelley, Kelly, Kelly, Kendall, Kusian, Lotlikar, Marcus, Menefee, Merlin, Muraoka, Ozensoy Guler, Parkhill, Pinard, Sheppard, Smith, Sokol, St Maurice, Stahl, Stahl, Stähler, Supuran, Supuran, Supuran, Velayudhan, Velayudhan, Vilas, Vliet, Vorwerk, Wilks   +61 more
core   +1 more source

Heterocyclic compounds as carbonic anhydrase inhibitor [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2011
The carbonic anhydrases (CAs, EC 4.2.1.1) constitute interesting targets for the design of pharmacological agents useful in the treatment or prevention of a variety of disorders such as, glaucoma, acid-base disequilibria, epilepsy, and other neuromuscular diseases, altitude sickness, edema, and obesity.
Asif, Husain, Diwakar, Madhesia
openaire   +2 more sources

Beyond CO2: Incorporating Bicarbonate, Dynamic Carbon Speciation, and Stoichiometric Plasticity Into Algal Growth Models

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The design of biological carbon capture systems to uptake carbon dioxide by photoautotrophic cultivation of algae has been proposed to mitigate atmospheric carbon emissions. Multiple models to predict algal growth as a function of nutrients have been proposed, but few have delved into the complex dynamic reactions of algal growth as influenced
Elizabeth Flanagan, Caye Drapcho, Mary Katherine Watson   +2 more
wiley   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Innovative molecular diagnosis of Trichinella species based on β-carbonic anhydrase genomic sequence [PDF]

, 2015
Trichinellosis is a helminthic infection where different species of Trichinella nematodes are the causative agents. Several molecular assays have been designed to aid diagnostics of trichinellosis. These assays are mostly complex and expensive.
Ancelle T., Fawcett T.W., Froscher W., Kumar V., Merlin C., Nelson M.   +5 more
core   +1 more source