Results 71 to 80 of about 23,970 (278)

Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII)

, 2015
Carbonic anhydrases (CAs) are widespread metalloenzymes in higher vertebrates including humans. A series of phenolic compounds, including guaiacol, 4-methylguaiacol, 4-propylguaiacol, eugenol, isoeugenol, vanillin, syringaldehyde, catechol, 3-methyl ...
Passaponti, Maurizio, SUPURAN, Claudiu T., GÜLÇİN, İlhami, Scozzafava, Andrea   +3 more
core   +1 more source

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, EarlyView.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm, Jachym Hrusak, Paul E. Reyes‐Gutierrez, Milan Vrabel   +6 more
wiley   +1 more source

Synthesis of Novel C‐Acyl‐Glycosyl Sulfonamides via Pd‐Catalyzed Carbonylative Coupling

European Journal of Organic Chemistry, EarlyView.
A Pd‐catalyzed carbonylative coupling of 1‐iodo‐glycals with diverse sulfonamides using Mo(CO)6 enables efficient access to C‐acyl‐glycosyl sulfonamides.This robust and versatile strategy delivers novel glycoside derivatives in good to excellent yields, highlighting their potential for drug discovery.
João A. F. Silva, Mônica F. Z. J. Toledo, Flávia Manarin, João H. de Araujo‐Neto, Milene M. Hornink, Hélio A. Stefani   +5 more
wiley   +1 more source

Investigation of Bacterial Carbonic Anhydrase Stability

, 2020
The purpose of this study was to investigate the stability of Bartonella henselae carbonic anhydrase in an effort to design screening methods for potential inhibitors.
Sutaria, Yatri
core  

Ketogenic diet therapy for children with super‐refractory status epilepticus in intensive care: International clinical practice recommendations

Epilepsia Open, EarlyView.
Abstract Objective We aimed to create practical recommendations to support healthcare teams starting ketogenic diet therapy (KDT) for children with super‐refractory status epilepticus in intensive care settings. Methods A literature review was conducted to extract published data on patient selection, diet prescription, diet initiation, monitoring, fine‐
Robyn Blackford, Victoria J. Whiteley, Isobel Hardy, Marisa Armeno, Tessa Bollard, J. Helen Cross, Christin Eltze, Susan George, Charlotte Howard, A. Laura Nijstad, Erin Talzzia, Chris Paget, Samiran Ray, Zoe Simpson, Elizabeth Song‐Pozderac, Agnieszka Szmurlo, Charlene Tan‐Smith, Lisa Vanatta, Elles van der Louw, Natasha E. Schoeler, on behalf of the Ketogenic Dietitians Research Network   +20 more
wiley   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Isoxazole–Thiazole Hybrids: Synthesis, Structural Characterisation, Carbonic Anhydrase Inhibition, and Molecular Docking Studies

Molecules
A new series of isoxazole-fused thiazole–oxazole derivatives (11a–n) was rationally designed and synthesised with the aim of developing potent carbonic anhydrase (CA) I and II inhibitors.
Nurcan Berber, Özge Nur Türkeri, Faika Başoğlu, Kubra Çıkrıkcı, Adem Ergün, Nahit Gencer   +5 more
doaj   +1 more source

The interaction of inhibitors with carbonic anhydrase

, 1991
The binding of several inhibitors to the metal site of carbonic anhydrase has been investigated through multinuclear ...
I. Bertini, SOLA, Marco, C. Luchinat, L. Banci   +3 more
core  

Carbonic anhydrase inhibitors for the treatment of epilepsy and obesity

, 2019
Recent advances in the management of epilepsy and obesity or obesity-related diseases have accounted for the carbonic anhydrase inhibitors becoming clinically used drugs.
Carta, F., Fabrizio Carta, Carta F., Berrino, E., Berrino E., Emanuela Berrino   +5 more
core   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source