Results 51 to 60 of about 695,880 (253)

Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The mitochondrial isoforms VA/VB of metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) are involved in metabolic processes, such as de novo lipogenesis and fatty acid biosynthesis.
Claudiu T. Supuran
doaj   +1 more source

Interaction of Coumarin, Daphnetin, Fraxetin from Natural Materials with Carbanoic anhydrase II in Inhibiting Glaucoma

Sains Natural
This article explores the interaction of Coumarin compounds and their derivatives obtained from natural extracts with Carbonic anhydrase II protein in inhibiting Glaucoma computationally.
Rismi Verawati, Fajri Ikhsan, Okta Suryani   +2 more
doaj   +1 more source

Carbonic Anhydrase Inhibitors from Marine Natural Products

Marine Drugs, 2022
Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread metalloenzymes in organisms in all life kingdoms, being involved in pH regulation, metabolic processes and many other physiological and pathological conditions.
Claudiu T. Supuran
doaj   +1 more source

Activity of carbonic anhydrase inhibitors in breast cancer models. [PDF]

, 2016
Evaluation of carbonic anhydrase inhibitors activity in breast cancer 2D and 3D ...
Želvytė, Aušra,
core  

Prospects for the application of inhibitors of carbonic anhydrase isoforms IX and XII in oncology

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Human carbonic anhydrase isoforms IX and XII play a key role in maintaining acid-base balance in solid tumors, creating a favorable microenvironment for the growth, invasion and metastasis of tumor cells.
S. А. Kalinin, Т. V. Sharonova, А. М. Malkova, S. V. Ageev, К. N. Semenov, V. V. Sharoyko   +5 more
doaj   +1 more source

MCM2 and Carbonic Anhydrase 9 Are Novel Potential Targets for Neuroblastoma Pharmacological Treatment

Biomedicines, 2020
To overcome the lack of effective pharmacological treatments for high-risk neuroblastoma (HR-NB), the development of novel in vitro and in vivo models that better recapitulate the disease is required.
Patrizia Garbati, Raffaella Barbieri, Davide Cangelosi, Carlo Zanon, Delfina Costa, Alessandra Eva, Stefano Thellung, Matilde Calderoni, Francesca Baldini, Gian Paolo Tonini, Paola Modesto, Tullio Florio, Aldo Pagano   +12 more
doaj   +1 more source

A new role for carbonic anhydrase 2 in the response of fish to copper and osmotic stress: Implications for multi-stressor studies [PDF]

, 2014
Copyright @ 2014 de Polo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
de Polo Anna, Scrimshaw, Mark D., Scrimshaw Mark D., Scrimshaw, MD, De Polo, A, Margiotta-Casaluci, Luigi; id_orcid, Margiotta-Casaluci, L, Margiotta-Casaluci Luigi, Lockyer, AE, Mark D. Scrimshaw (637445), Lockyer Anne E., de Polo, Anna, Anna de Polo, Anne E. Lockyer (107520), Luigi Margiotta-Casaluci, Margiotta-Casaluci, Luigi, Mark D Scrimshaw, Luigi Margiotta-Casaluci (637444), Lockyer, Anne E., Anna de Polo (637443), Anne E Lockyer   +20 more
core   +1 more source

Plasma Proteome Reflects Tissue Damage and Clinical Manifestations in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Tissue‐specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue‐derived proteins.
Yue‐Bei Luo, Josefin Kenrick, Angeles S. Galindo‐Feria, Antonella Notarnicola, Ana Daniela Ulloa Navas, Irene Peralta‐Garcia, Orane Demuynck, Andrea Kemp, Valérie Leclair, Karin Lodin, Eveline Van Gompel, Lara Dani, Fabricio Espinosa‐Ortega, Maryam Dastmalchi, Leonid Padyukov, Charlotta Preger, María Bueno Álvez, Mathias Uhlén, Peter Nilsson, Fredrik Edfors, Lina‐Marcela Diaz‐Gallo, Elisa Pin, Ingrid E. Lundberg, Begum Horuluoglu   +23 more
wiley   +1 more source

Quinazolinones as Competitive Inhibitors of Carbonic Anhydrase-II (Human and Bovine): Synthesis, in-vitro, in-silico, Selectivity, and Kinetics Studies

Frontiers in Chemistry, 2020
Carbonic anhydrase-II (CA-II) is associated with glaucoma, malignant brain tumors, and renal, gastric, and pancreatic carcinomas and is mainly involved in the regulation of the bicarbonate concentration in the eyes. CA-II inhibitors can be used to reduce
Ajmal Khan, Majid Khan, Majid Khan, Sobia Ahsan Halim, Zulfiqar Ali Khan, Zahid Shafiq, Ahmed Al-Harrasi   +6 more
doaj   +1 more source

A Theoretical Study of Conformation-Electronic Structure Relationships in Benzensulfonamide Inhibitors of Carbonic Anhydrase Enzyme.

, 1989
A Theoretical Study of Conformation-Electronic Structure Relationships in Benzensulfonamide Inhibitors of Carbonic Anhydrase ...
COCCHI, Marina, FRASSINETI, Chiara, DE BENEDETTI, Pier Giuseppe, MENZIANI, Maria Cristina   +3 more
core   +1 more source