Results 41 to 50 of about 695,880 (253)

SYNTHESIS, BIOCHEMICAL AND IN SILICO EXPLORATION OF NOVEL IMIDAZOLE BASED 1,2,3-TRIAZOLES AS POTENTIAL HIT AGAINST CARBONIC ANHYDRASE II ISOZYME [PDF]

Química Nova
This study aimed to synthesize novel compounds as more effective carbonic anhydrase II inhibitors. For this purpose, 2-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)-4,5-diphenyl-1H-imidazole (3) was reacted with 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde ...
Mumtaz Hussain, Pervaiz Ali Channar, Aisha A. Alsfouk, Syeda Abida Ejaz, Mubashir Aziz, Zahid Hussain, Ghulam Abbas Kandhro, Hafiz Muhammad Attaullah, Rabail Ujhan, Mushtaque Ali Jakhrani, Aamer Saeed, Qamar Abbas, Laith Abualigah   +12 more
doaj   +1 more source

Conformational effects on the Circular Dichroism of Human Carbonic Anhydrase II: a multilevel computational study [PDF]

, 2013
Circular Dichroism (CD) spectroscopy is a powerful method for investigating conformational changes in proteins and therefore has numerous applications in structural and molecular biology. Here a computational investigation of the CD spectrum of the Human
Uno Carlsson, Kia Balali-Mood (210078), Karabencheva-Christova, Tatyana G, Balali-Mood Kia, Gary W. Black (382116), Black Gary W., Carlsson, Uno,, Kia Balali-Mood, Christov, Christo Z., Carlsson, Uno, Balali-Mood, Kia,, Christo Z Christov, Christov, Christo, Christov Christo Z., Karabencheva-Christova, Tatyana G,, Tatyana G. Karabencheva-Christova (382114), Uno Carlsson (382115), Black, Gary W., Karabencheva-Christova, Tatyana, Christo Z. Christov (382117), Tatyana G Karabencheva-Christova, Balali-Mood, Kia, Karabencheva-Christova Tatyana G., Carlsson Uno, Black, Gary W.,, Gary W Black, Black, Gary, Christov, Christo Z.,   +27 more
core   +1 more source

The Effect of Hydrophilic Headgroup Chemistry on Peptoid‐Directed Mineralization of CaCO3

Advanced Functional Materials, EarlyView.
Amphiphilic peptoids alter the pathway and outcome of calcium carbonate crystallization, which progresses through amorphous calcium carbonate (ACC) to vaterite to calcite rhombs in the absence of peptoids. In contrast, amine‐terminated peptoids produce vaterite disks and carboxyl‐terminated peptoids produce calcite mesocrystals.
Biao Jin, Chunhui Wu, Thi Kim Hoang Trinh, Wenhao Zhou, Chun‐Long Chen, James J De Yoreo   +5 more
wiley   +1 more source

Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
We report the synthesis and characterisation of a novel series of triazole benzenesulfonamide derivatives, which incorporate the general pharmacophore associated with carbonic anhydrase (CA, EC 4.2.1.1) inhibitors.
Marwa G. El-Gazzar, Nessma H. Nafie, Alessio Nocentini, Mostafa M. Ghorab, Helmi I. Heiba, Claudiu T. Supuran   +5 more
doaj   +1 more source

A Combined in Silico and Structural Study Opens New Perspectives on Aliphatic Sulfonamides, a Still Poorly Investigated Class of CA Inhibitors

Biology, 2023
Aliphatic sulfonamides are an interesting class of carbonic anhydrase inhibitors (CAIs) proven to be effective for several carbonic anhydrase (CA) isoforms involved in pathologic states. Here we report the crystallographic structures of hCA II in complex
Emma Langella, Davide Esposito, Simona Maria Monti, Claudiu T. Supuran, Giuseppina De Simone, Vincenzo Alterio   +5 more
doaj   +1 more source

Synthesis of some natural sulphonamide derivatives as carbonic anhydrase inhibitors

, 2017
Carbonic anhydrase inhibitor; sulphonamides; p-hydroxybenzoic acid; 3,4,5-trihydroxybenzoic acid (gallic acid).Carbonic anhydrase inhibitors are both in clinical use as antiglaucoma, diuretics, antiepileptics and management of altitude sickness, and ...
Melike Al, Turan Ozturk, Ahmet C Goren, Topal, Meryem, Goren, Ahmet C., OZTURK, Turan, Meryem Topal, AL, Melike, Gokcen, Taner, GÜLÇİN, İlhami, İlhami Gulcin, Taner Gokcen   +11 more
core   +1 more source

Catechols: A new class of carbonic anhydrase inhibitors [PDF]

, 2020
To date, catechols have been only poorly investigated as carbonic anhydrase (CA) inhibitors. Here we report the first structural information on the CA inhibition mechanismof these molecules, showing that they adopt a peculiar binding mode to the ...
D'Ambrosio K., Carradori S., Supuran C. T., Monti S. M., Cesa S., De Simone G., Angeli A., Cesa Stefania, Carradori Simone, Angeli, A., Supuran Claudiu T, Angeli Andrea, De Simone Giuseppina, D'Ambrosio Katia, Supuran, C. T., Monti Simona M, Simona M. Monti, Simone Carradori, Giuseppina De Simone, Katia D'Ambrosio, Stefania Cesa, Andrea Angeli, Claudiu T. Supuran   +22 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to Neisseria gonorrhoeae α‑Carbonic Anhydrase

, 2022
Drug-resistant Neisseria gonorrhoeae is a critical threat to public health, and bacterial carbonic anhydrases expressed by N. gonorrhoeae are potential new therapeutic targets to combat this pathogen.
Katrina J. Holly (10452264), Ravi Yadav (6860603), Claudiu T. Supuran (24658), Anil Kumar Marapaka (1936357), Molly S. Youse (10452261), Alessio Nocentini (3355211), Mohamed N. Seleem (680869), Chittaranjan Das (143441), Daniel P. Flaherty (1340721), Weiwei An (767986)   +9 more
core   +2 more sources

Exploring the multi-target enzyme inhibition potential of new sulfonamido-thiazoline derivatives; synthesis and computational studies

Results in Chemistry, 2022
A small library of ten new Nimesulide-iminothiazolines conjugates was synthesized by the reduction of nitro group of Nimesulide followed by conversion into variously substituted acyl thioureas.
Imran Shafique, Aamer Saeed, Atteeque Ahmed, Ghulam Shabir, Anwar Ul-Hamıd, Ajmal Khan, Burak Tüzün, Mahinur Kirici, Parham Taslimi, Muhammad Latif   +9 more
doaj   +1 more source