Results 61 to 70 of about 695,880 (253)

Artificial Cell Catalysts for Biotransformation: Design Principles and Process Integration

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Artificial cell catalysts are emerging as programmable biocatalytic platforms for sustainable molecular conversion. By reconstituting enzymes and functional modules within synthetic compartments, they combine the selectivity of biological catalysis with the design flexibility of synthetic materials.
Iori Kobayashi, Shogo Yoshimoto, Katsutoshi Hori   +2 more
wiley   +1 more source

Out of the active site binding pocket for carbonic anhydrase inhibitors

, 2015
A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this ...
De Simone, G., CARRADORI, Simone, Supuran, Ct, Secci, D, D'Ambrosio, K, Monti, Sm, Vullo, D, Buonanno, M   +7 more
core   +2 more sources

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis   +12 more
wiley   +1 more source

Stereochemistry matters: Inhibition of carbonic anhydrase II by amino acid derived sulfamates depends on their absolute configuration

European Journal of Medicinal Chemistry Reports
Aminoalcohols were converted into the corresponding enantiomeric phenylsulfonamide sulfamates. These compounds proved to be inhibitors of carbonic anhydrase II.
Toni C. Denner, Elsa L. Klett, Niels V. Heise, René Csuk   +3 more
doaj   +1 more source

Exploring Elimination Profiles and Metabolite Patterns of Brinzolamide and Dorzolamide After Transdermal Exposure for Doping Control Purposes

ELECTROPHORESIS, EarlyView.
Dermal exposure to the carbonic anhydrase inhibitors dorzolamide and brinzolamide is detected in blood and urine using liquid chromatography–high‐resolution/high‐accuracy mass spectrometry. Contamination at milligram level can, therefore, lead to adverse analytical findings in sports drug testing.
Yao Jin, Andreas Thomas, Mario Thevis
wiley   +1 more source

CARBONIC ANHYDRASE IN Plasmodium falciparum: A USEFUL TARGET FOR ANTIMALARIAL DRUG DESIGNING AND MALARIA blocking TRANSMISSION COMPOUNDS

Vitae, 2010
Carbonic anhydrase is a metalloenzyme that catalyzes the reversible conversion of CO2 to bicarbonate, an essential metabolic component used by the malaria parasites for de novo synthesis of pyrimidines and the exflagelation of gametocytes inside the ...
Carlos D. AGUDELO R., María CORENA-Mcleod, Sara M. ROBLEDO R.   +2 more
doaj  

Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Testing of an expanded, 800-compound set of analogues of the earlier described Strecker-type α-aminonitriles (selected from publicly available Enamine Ltd.
Mikhail Krasavin, Stanislav Kalinin, Sergey Zozulya, Anastasia Griniukova, Petro Borysko, Andrea Angeli, Claudiu T. Supuran   +6 more
doaj   +1 more source

Synthesis And Biological Evaluation Of New 4-Thiazolidinone Derivatives As Carbonic Anhydrase Inhibitors [PDF]

, 2017
Conclusion: New aminoindane thiazolidinone derivatives have been designed, synthesized and evaluated as Carbonic Anhydrase Inhibitors. According to the results, these compounds can be conceivable as new candidates for the treatment of the illness that ...
Busra Ceken, Sackes, Zubeyde, Bilen, Cigdem, Arslan, Oktay, Cigdem Bilen, Zubeyde Sackes, Gencer, Nahit, Hayriye Genc, Nahit Gencer, Genç Bilgiçli, Hayriye, Genc, Hayriye, Ceken, Busra, Oktay Arslan, Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü, Bilgiçli, Hayriye Genç   +14 more
core   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Topical carbonic anhydrase inhibitors and visual function in glaucoma and ocular hypertension

, 2010
Dorzolamide and brinzolamide are topical carbonic anhydrase inhibitors (CAI) indicated for patients with glaucoma and ocular ...
Gugleta, Konstantin, Gugleta K, Konstantin Gugleta   +2 more
core   +1 more source