Results 61 to 70 of about 42,053 (258)

Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The mitochondrial isoforms VA/VB of metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) are involved in metabolic processes, such as de novo lipogenesis and fatty acid biosynthesis.
Claudiu T. Supuran
doaj   +1 more source

Chemical probing suggests redox-regulation of the carbonic anhydrase activity of mycobacterial Rv1284 [PDF]

, 2015
The mycobacterial enzyme Rv1284 is a member of the ߭carbonic anhydrase family that is considered essential for survival of the pathogen. The active site cavity of this dimeric protein is characterized by an exceptionally small volume and harbours a ...
Abas, Adams, Betts, Bhat, Bryson, Brünger, Brünger, Chim, Collaborative Computational Project Number 4, Dolinsky, Ehrt, Emsley, Gnielinski, Hofmann, Hofmann, Jones, Kabsch, Kang, Khalifah, Kimber, Kumar, Lane, McPhillips, Radchenko, Rowlett, Sassetti, Schnappinger, Schoepfer, Shiloh, Suarez Covarrubias, Suarez Covarrubias, Thakur, Tripp, Voskuil, Wang, Wang, Wang, Wayne, Zimmerman   +38 more
core   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Interaction of Coumarin, Daphnetin, Fraxetin from Natural Materials with Carbanoic anhydrase II in Inhibiting Glaucoma

Sains Natural
This article explores the interaction of Coumarin compounds and their derivatives obtained from natural extracts with Carbonic anhydrase II protein in inhibiting Glaucoma computationally.
Rismi Verawati, Fajri Ikhsan, Okta Suryani   +2 more
doaj   +1 more source

MCM2 and Carbonic Anhydrase 9 Are Novel Potential Targets for Neuroblastoma Pharmacological Treatment

Biomedicines, 2020
To overcome the lack of effective pharmacological treatments for high-risk neuroblastoma (HR-NB), the development of novel in vitro and in vivo models that better recapitulate the disease is required.
Patrizia Garbati, Raffaella Barbieri, Davide Cangelosi, Carlo Zanon, Delfina Costa, Alessandra Eva, Stefano Thellung, Matilde Calderoni, Francesca Baldini, Gian Paolo Tonini, Paola Modesto, Tullio Florio, Aldo Pagano   +12 more
doaj   +1 more source

Organic Photoelectrochemical Cells Beyond Performance: Interface and Catalyst Engineering for Durability

Advanced Energy Materials, EarlyView.
Organic photoelectrochemical cells based on π‐conjugated semiconductors offer a versatile platform for solar fuel generation. This review outlines operating principles, device architectures, and key metrics, and highlights advances in p‐ and n‐type photoelectrodes, interfacial engineering, and catalyst integration.
Jaehyeong Kim, Jung Min Ha, Yeonjeong Lee, Seung Won Oh, Wangyeon Lee, Munsu Kwon, Soonyong Lee, Jin Young Kim, Han Young Woo   +8 more
wiley   +1 more source

Rare diseases leading to childhood Glaucoma. epidemiology, pathophysiogenesis, and management [PDF]

, 2015
Noteworthy heterogeneity exists in the rare diseases associated with childhood glaucoma. Primary congenital glaucoma is mostly sporadic; however, 10% to 40% of cases are familial. CYP1B1 gene mutations seem to account for 87% of familial cases and 27% of
Abdolrahimzadeh, Solmaz, CONTESTABILE, Maria Teresa, FAMELI, VALERIA, Mollo, Roberto, Perdicchi, Andrea, RECUPERO, Santi Maria   +5 more
core   +9 more sources

Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients

Clinical Ophthalmology, 2010
Adam M Moss, Alon Harris, Brent Siesky, Deepam Rusia, Kathleen M Williamson, Yochai ShoshaniDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USAAbstract: Topical hypotensive therapy with both timolol and carbonic
Adam M Moss, Alon Harris, Brent Siesky, et al   +3 more
doaj  

Prospects for the application of inhibitors of carbonic anhydrase isoforms IX and XII in oncology

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Human carbonic anhydrase isoforms IX and XII play a key role in maintaining acid-base balance in solid tumors, creating a favorable microenvironment for the growth, invasion and metastasis of tumor cells.
S. А. Kalinin, Т. V. Sharonova, А. М. Malkova, S. V. Ageev, К. N. Semenov, V. V. Sharoyko   +5 more
doaj   +1 more source

Quinazolinones as Competitive Inhibitors of Carbonic Anhydrase-II (Human and Bovine): Synthesis, in-vitro, in-silico, Selectivity, and Kinetics Studies

Frontiers in Chemistry, 2020
Carbonic anhydrase-II (CA-II) is associated with glaucoma, malignant brain tumors, and renal, gastric, and pancreatic carcinomas and is mainly involved in the regulation of the bicarbonate concentration in the eyes. CA-II inhibitors can be used to reduce
Ajmal Khan, Majid Khan, Majid Khan, Sobia Ahsan Halim, Zulfiqar Ali Khan, Zahid Shafiq, Ahmed Al-Harrasi   +6 more
doaj   +1 more source