Results 21 to 30 of about 20,404 (233)

Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis: a systematic review and meta-analysis of randomized controlled trials

Critical Care, 2018
Background Metabolic alkalosis is common in patients with respiratory failure and may delay weaning in mechanically ventilated patients. Carbonic anhydrase inhibitors block renal bicarbonate reabsorption, and thus reverse metabolic alkalosis.
Bassem Y Tanios, Maryam O Omran, Carlos Noujeim, Tamara Lotfi, Samir S Mallat, Pierre K Bou-Khalil, Elie A Akl, Houssam S Itani   +7 more
doaj   +1 more source

First episode psychotic disorder possibly associated with acetazolamide in a male adolescent with congenital glaucoma [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2015
Primer congenital glaucoma is an uncommon ophthalmological disease manifesting at birth and accounting for 0.01-0.04% of total blindness. Acetozalamide, a carbonic anhydrase inhibitor is one of the options in the medical treatment of glaucoma and acute ...
ozhan yalcin
doaj  

Inhibitory effects of sulfenimides on human and bovine carbonic anhydrase enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A series of sulfenimide derivatives (1a-i) were investigated as inhibitors of human (hCA-I, hCA-II) and bovine (bCA) carbonic anhydrase enzymes. The compounds were synthesised by the reaction of substituted thiophenols with phthalimide by means of an ...
Hasan Yakan, Gürkan Bilir, Şükriye Çakmak, Ömer Taş, Nalan Türköz Karakullukçu, Ercan Soydan, Halil Kütük, Coşkun Güçlü, Murat Şentürk, Tayfun Arslan, Seyhan Öztürk, Ercüment Aksakal, Deniz Ekinci   +12 more
doaj   +1 more source

Beyond Canonical CO Oxidation: Structural and Evolutionary Insights Into a Non‐Canonical Carbon Monoxide Dehydrogenase

Angewandte Chemie, EarlyView.
Clade B carbon monoxide dehydrogenases (CODHs) remain enigmatic, diverging from canonical CODHs in structure and function. Here, we present the first characterization of Ruminococcus flavefaciens CODH (RfCODH), revealing occluded substrate pathways and attenuated CO oxidation activity.
Maximilian Böhm, Vivek Srinivas, Benjamin Wiseman, Ping Huang, Moritz Senger, Martin Högbom, Henrik Land   +6 more
wiley   +2 more sources

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

Angewandte Chemie, EarlyView.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, Renzo Luisi   +9 more
wiley   +2 more sources

Carbonic anhydrase inhibitory properties of some uracil derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Inhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4–12) to inhibit human CA I (hCA I) and II (hCA II) isoenzymes. The KI
Emir Alper Türkoğlu, Murat Şentürk, Claudiu T. Supuran, Deniz Ekinci   +3 more
doaj   +1 more source

Carbonic Anhydrase Inhibitors suppress platelet procoagulant responses and in vivo thrombosis: Carbonic Anhydrase Inhibitors as Antithrombotics

Platelets, 2020
Carbonic anhydrase (CA) inhibitors have a long history of safe clinical use as mild diuretics, in the treatment of glaucoma and for altitude sickness prevention.
Ejaife O. Agbani, Xiaojuan Zhao, Christopher M. Williams, Riyaad Aungraheeta, Ingeborg Hers, Erik R. Swenson, Alastair W. Poole   +6 more
doaj   +1 more source

Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Click chemistry reactions constitute an important and relatively new approach in the medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms of overcoming the limitations of facile chemical synthesis, increased ...
Andrea Angeli, Claudiu T. Supuran
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

SYNTHESIS, BIOCHEMICAL AND IN SILICO EXPLORATION OF NOVEL IMIDAZOLE BASED 1,2,3-TRIAZOLES AS POTENTIAL HIT AGAINST CARBONIC ANHYDRASE II ISOZYME [PDF]

Química Nova
This study aimed to synthesize novel compounds as more effective carbonic anhydrase II inhibitors. For this purpose, 2-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)-4,5-diphenyl-1H-imidazole (3) was reacted with 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde ...
Mumtaz Hussain, Pervaiz Ali Channar, Aisha A. Alsfouk, Syeda Abida Ejaz, Mubashir Aziz, Zahid Hussain, Ghulam Abbas Kandhro, Hafiz Muhammad Attaullah, Rabail Ujhan, Mushtaque Ali Jakhrani, Aamer Saeed, Qamar Abbas, Laith Abualigah   +12 more
doaj   +1 more source