Results 21 to 30 of about 648,149 (287)

Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models [PDF]

, 2015
This research was financed in part by a Grant of the 7th Framework Program of the European Union (METOXIA project; HEALTH‐F2‐2009‐222741) and the NGI Pre- Seed grant (NWO n° 93613002).Triple negative, resistant or metastatic disease are major factors in ...
Kunkler, Ian H., Meehan, James, Renshaw, Lorna, Ward, Carol, Dubois, Ludwig, Harrison, David James, Langdon, Simon P., Dixon, J. Michael, Mullen, Peter, Um, In Hwa, Kay, Charlene, Jarman, Edward J., Supuran, Claudiu, Lambin, Philippe, Winum, Jean-Yves, Pavathaneni, Nanda-Kumar, Thomas, Jeremy S.   +16 more
core   +4 more sources

Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XII

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The Carbonic anhydrase isoforms IX and XII play a significant role in regulating the intracellular and extracellular pH in hypoxic tumours abetting the metastasis of solid tumours.
Shaik Mahammad Ghouse, Kavyaraj Bahatam, Andrea Angeli, Gaurav Pawar, Krishna Kartheek Chinchilli, Venkata Madhavi Yaddanapudi, Arifuddin Mohammed, Claudiu T. Supuran, Srinivas Nanduri   +8 more
doaj   +1 more source

Multivalent Carbonic Anhydrases Inhibitors [PDF]

International Journal of Molecular Sciences, 2019
Biomolecular recognition using a multivalent strategy has been successfully applied, this last decade on several biological targets, especially carbohydrate-processing enzymes, proteases, and phosphorylases. This strategy is based on the fact that multivalent interactions of several inhibitory binding units grafted on a presentation platform may ...
Fabrizio Carta, Pascal Dumy, Claudiu T. Supuran, Jean-Yves Winum   +3 more
openaire   +3 more sources

Carbonic Anhydrase Inhibitors

Kidney and Blood Pressure Research, 1987
The purpose of the present review is to describe the use of carbonic anhydrase inhibitors in clinical medicine and renal physiology. We first describe the localization of carbonic anhydrase within the kidney and then discuss evidence for its role in renal acidification and NaCl absorption.
P A, Preisig, R D, Toto, R J, Alpern
openaire   +3 more sources

Synthesis of New 1H-1,2,3-Triazole Analogs in Aqueous Medium via “Click” Chemistry: A Novel Class of Potential Carbonic Anhydrase-II Inhibitors

Frontiers in Chemistry, 2021
A series of novel 1H-1,2,3-triazole analogs (9a–j) were synthesized via “Click” chemistry and Suzuki–Miyaura cross-coupling reaction in aqueous medium. The compounds were evaluated for their carbonic anhydrase-II enzyme inhibitory activity in vitro.
Satya Kumar Avula, Majid Khan, Majid Khan, Sobia Ahsan Halim, Ajmal Khan, Samia Ahmed Al-Riyami, Rene Csuk, Biswanath Das, Ahmed Al-Harrasi   +8 more
doaj   +1 more source

Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111.
Mazin A. A. Najm, Walaa R. Mahmoud, Azza T. Taher, Safinaz E-S. Abbas, Fadi M. Awadallah, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran   +7 more
doaj   +1 more source

The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cardiovascular diseases are the leading cause of mortality worldwide. In recent years, the relationship between carbonic anhydrase inhibitors and atherosclerosis has attracted attention.
Onur Argan, Kübra Çıkrıkçı, Aybike Baltacı, Nahit Gencer   +3 more
doaj   +1 more source

Inorganic carbon acquisition in Palmaria palmata (Rhodophyta) [PDF]

, 2010
PhDDIC acquisition mechanisms and the use of DIC in photosynthesis were examined in the temperate red macroalga, Palmaria palmata (Linnaeus) O. Kuntze.
Hill, Gregg
core   +4 more sources

Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I

Oftalʹmologiâ, 2020
Glaucoma is the main cause of irreversible blindness in the world. Carbonic anhydrase inhibitors (CAIS) used both systemically and topically, reduce intraocular pressure effectively.
N. I. Kurysheva
doaj   +1 more source

Role of carbon dioxide and ion transport in the formation of sub-embryonic fluid by the blastoderm of the Japanese quail [PDF]

, 2002
1. The explanted blastoderm of the Japanese quail was used to explore the role of ions and carbon dioxide in determining the rate of sub-embryonic fluid (SEF) production between 54 and 72 h of incubation. 2.
Latter, G.V., Baggott, Glenn K.
core   +1 more source