Results 11 to 20 of about 23,970 (278)

5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II.
Stanislav Kalinin, Alexander Kovalenko, Annika Valtari, Alessio Nocentini, Maxim Gureev, Arto Urtti, Mikhail Korsakov, Claudiu T. Supuran, Mikhail Krasavin   +8 more
doaj   +2 more sources

Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients

Clinical Ophthalmology, 2010
Adam M Moss, Alon Harris, Brent Siesky, Deepam Rusia, Kathleen M Williamson, Yochai ShoshaniDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USAAbstract: Topical hypotensive therapy with both timolol and carbonic
Adam M Moss, Alon Harris, Brent Siesky, et al   +3 more
doaj   +1 more source

Prospects for the application of inhibitors of carbonic anhydrase isoforms IX and XII in oncology [PDF]

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Human carbonic anhydrase isoforms IX and XII play a key role in maintaining acid-base balance in solid tumors, creating a favorable microenvironment for the growth, invasion and metastasis of tumor cells.
S. А. Kalinin, Т. V. Sharonova, А. М. Malkova, S. V. Ageev, К. N. Semenov, V. V. Sharoyko   +5 more
doaj   +2 more sources

Coumarin carbonic anhydrase inhibitors from natural sources

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Coumarins constitute a relatively new class of inhibitors of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), possessing a unique inhibition mechanism, acting as “prodrug inhibitors.” They undergo the hydrolysis of the lactone ring mediated by the ...
Claudiu T. Supuran
doaj   +2 more sources

Synthesis of New 1H-1,2,3-Triazole Analogs in Aqueous Medium via “Click” Chemistry: A Novel Class of Potential Carbonic Anhydrase-II Inhibitors

Frontiers in Chemistry, 2021
A series of novel 1H-1,2,3-triazole analogs (9a–j) were synthesized via “Click” chemistry and Suzuki–Miyaura cross-coupling reaction in aqueous medium. The compounds were evaluated for their carbonic anhydrase-II enzyme inhibitory activity in vitro.
Satya Kumar Avula, Majid Khan, Majid Khan, Sobia Ahsan Halim, Ajmal Khan, Samia Ahmed Al-Riyami, Rene Csuk, Biswanath Das, Ahmed Al-Harrasi   +8 more
doaj   +1 more source

Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111.
Mazin A. A. Najm, Walaa R. Mahmoud, Azza T. Taher, Safinaz E-S. Abbas, Fadi M. Awadallah, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran   +7 more
doaj   +1 more source

Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to Neisseria gonorrhoeae α‑Carbonic Anhydrase

, 2022
Drug-resistant Neisseria gonorrhoeae is a critical threat to public health, and bacterial carbonic anhydrases expressed by N. gonorrhoeae are potential new therapeutic targets to combat this pathogen.
Katrina J. Holly (10452264), Ravi Yadav (6860603), Claudiu T. Supuran (24658), Anil Kumar Marapaka (1936357), Molly S. Youse (10452261), Alessio Nocentini (3355211), Mohamed N. Seleem (680869), Chittaranjan Das (143441), Daniel P. Flaherty (1340721), Weiwei An (767986)   +9 more
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Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models [PDF]

, 2015
This research was financed in part by a Grant of the 7th Framework Program of the European Union (METOXIA project; HEALTH‐F2‐2009‐222741) and the NGI Pre- Seed grant (NWO n° 93613002).Triple negative, resistant or metastatic disease are major factors in ...
Kunkler, Ian H., Jarman, Edward J, Kunkler, Ian, Pavathaneni, Nanda- Kumar, Meehan, James, Jarman, Edward, Ward, Carol, Harrison, David James, Langdon, Simon P., Dixon, J. Michael, Um, In Hwa, Supuran, Claudiu, Lambin, Philippe, Winum, Jean-Yves, Um, Inhwa, Dixon, MIchael, Supuran, Claudiu Trandafir, Renshaw, Lorna, Harrison, David J, Dubois, Ludwig, Langdon, Simon, Thomas, Jeremy, Mullen, Peter, Kay, Charlene, Jarman, Edward J., Kay, Charlene; id_orcid, Supuran, Claudiu T, Harrison, David, Pavathaneni, Nanda-Kumar, Thomas, Jeremy S., Harrison, David J.   +30 more
core   +1 more source

The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cardiovascular diseases are the leading cause of mortality worldwide. In recent years, the relationship between carbonic anhydrase inhibitors and atherosclerosis has attracted attention.
Onur Argan, Kübra Çıkrıkçı, Aybike Baltacı, Nahit Gencer   +3 more
doaj   +1 more source

Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I

Oftalʹmologiâ, 2020
Glaucoma is the main cause of irreversible blindness in the world. Carbonic anhydrase inhibitors (CAIS) used both systemically and topically, reduce intraocular pressure effectively.
N. I. Kurysheva
doaj   +1 more source