Results 11 to 20 of about 695,880 (253)
5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II.
Stanislav Kalinin +8 more
doaj +2 more sources
Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been
Claudia Melis +9 more
doaj +2 more sources
Phenols and Polyphenols as Carbonic Anhydrase Inhibitors [PDF]
Molecules, 2016 Phenols are among the largest and most widely distributed groups of secondary metabolites within the plant kingdom. They are implicated in multiple and essential physiological functions.
Anastasia Karioti +2 more
doaj +4 more sources
Clinical Ophthalmology, 2010 Adam M Moss, Alon Harris, Brent Siesky, Deepam Rusia, Kathleen M Williamson, Yochai ShoshaniDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USAAbstract: Topical hypotensive therapy with both timolol and carbonic
Adam M Moss +3 more
doaj +1 more source
Human Carbonic Anhydrase Inhibitors. [PDF]
ACS Med Chem LettHumans encode 15 isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), which catalyzes the interconversion between CO2 and bicarbonate and is involved in a multitude of physiological/pathological processes. CA inhibitors are in clinical use as diuretics, anti-glaucoma drugs, anti-epileptics, and anti-obesity agents.
Supuran CT.
europepmc +3 more sources
Investigation into the Mechanism of Human Carbonic Anhydrase II [PDF]
, 2012 Human carbonic anhydrase II (HCAII) acts as a carbon dioxide sequestration catalyst, removing carbon dioxide from the blood stream and converting it into bicarbonate and a proton. The active site contains a tetrahedrally coordinated zinc atom coordinated
Saunders, Michael
core +6 more sources
Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models [PDF]
, 2015 This research was financed in part by a Grant of the 7th Framework Program of the European Union (METOXIA project; HEALTH‐F2‐2009‐222741) and the NGI Pre- Seed grant (NWO n° 93613002).Triple negative, resistant or metastatic disease are major factors in ...
Kunkler, Ian H. +16 more
core +3 more sources
Multivalent Carbonic Anhydrases Inhibitors [PDF]
International Journal of Molecular Sciences, 2019 Biomolecular recognition using a multivalent strategy has been successfully applied, this last decade on several biological targets, especially carbohydrate-processing enzymes, proteases, and phosphorylases. This strategy is based on the fact that multivalent interactions of several inhibitory binding units grafted on a presentation platform may ...
Carta, Fabrizio +3 more
openaire +3 more sources
Kidney and Blood Pressure Research, 1987 The purpose of the present review is to describe the use of carbonic anhydrase inhibitors in clinical medicine and renal physiology. We first describe the localization of carbonic anhydrase within the kidney and then discuss evidence for its role in renal acidification and NaCl absorption.
P A, Preisig, R D, Toto, R J, Alpern
openaire +3 more sources
, 2022 Mass spectrometry, SPR and CD data to accompany "Quantitative characterisation of three carbonic anhydrase inhibitors by LESA mass ...
Cooper, Helen; id_orcid, Biosciences
core +2 more sources