Results 11 to 20 of about 42,053 (258)
Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been
Claudia Melis +9 more
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Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid MonolayersSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2018 Background & Aims: Human enteroids present a novel tool to study human intestinal ion transport physiology and pathophysiology. The present study describes the contributions of Cl- and HCO3- secretion to total cyclic adenosine monophosphate (cAMP ...
Jianyi Yin +6 more
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Quantitative Characterization of the Chemical Space Governed by Human Carbonic Anhydrases and selenium-containing derivatives of solfonamides [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2022 Due to the fact that different isoforms of carbonic anhydrase play distinct physiological roles, their diseases/disorders involvement are different as well.
Behnam Rasti
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X-linked Juvenile Retinoschisis in a Young Female
Journal of Nepal Health Research Council, 2022 X-linked juvenile retinoschisis has recessive inheritance which occurs due to RS1 gene mutation. We report an instance in a female managed with systemic and topical carbonic-anhydrase inhibitors.
Sudha Ranabhat +2 more
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A clinical case of choroidal effusion associated with the use of carbonic anhydrase inhibitors
Офтальмохирургия, 2021 Relevance. Choroidal effusion is a complication accompanying both surgical interventions and ophthalmopathies of predominantly inflammatory etiology. The release of proteins from choriocapillaries lumen and decrease of intraocular pressure relative to ...
N. I. Kurysheva +3 more
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Microbiology Spectrum, 2023 The ADC (AmpC) β-lactamase is universally present in the Acinetobacter baumannii chromosome, suggesting it may have a yet-to-be-identified cellular function. Using peptidoglycan composition analysis, we show that overexpressing the ADC-7 β-lactamase in A.
Jennifer M. Colquhoun +6 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 The Carbonic anhydrase isoforms IX and XII play a significant role in regulating the intracellular and extracellular pH in hypoxic tumours abetting the metastasis of solid tumours.
Shaik Mahammad Ghouse +8 more
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Multivalent Carbonic Anhydrases Inhibitors [PDF]
International Journal of Molecular Sciences, 2019 Biomolecular recognition using a multivalent strategy has been successfully applied, this last decade on several biological targets, especially carbohydrate-processing enzymes, proteases, and phosphorylases. This strategy is based on the fact that multivalent interactions of several inhibitory binding units grafted on a presentation platform may ...
Fabrizio Carta +3 more
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The structure of a tetrameric α-carbonic anhydrase fromThermovibrio ammonificansreveals a core formed around intermolecular disulfides that contribute to its thermostability [PDF]
, 2014 Carbonic anhydrase enzymes catalyse the reversible hydration of carbon dioxide to bicarbonate. A thermophilic Thermovibrio ammonificans α-carbonic anhydrase (TaCA) has been expressed in Escherichia coli and structurally and biochemically characterized ...
Berg, Svein +7 more
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Kidney and Blood Pressure Research, 1987 The purpose of the present review is to describe the use of carbonic anhydrase inhibitors in clinical medicine and renal physiology. We first describe the localization of carbonic anhydrase within the kidney and then discuss evidence for its role in renal acidification and NaCl absorption.
P A, Preisig, R D, Toto, R J, Alpern
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