Results 11 to 20 of about 648,149 (287)

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors [PDF]

Molecules, 2016
Phenols are among the largest and most widely distributed groups of secondary metabolites within the plant kingdom. They are implicated in multiple and essential physiological functions.
Anastasia Karioti, Fabrizio Carta, Claudiu T. Supuran   +2 more
doaj   +5 more sources

Drug-drug interaction signals between carbonic anhydrase inhibitors and vitamin D preparations in urinary tract stones: disproportionality analysis evaluation from Japanese spontaneous reports of adverse events [PDF]

Journal of Pharmaceutical Health Care and Sciences
Background Carbonic anhydrase inhibitors used as antiepileptic drugs promote calcium phosphate stones. Patients with epilepsy often receive vitamin D concurrently, which may increase urinary calcium and stone formation. We analyzed drug-drug interactions
Teruhisa Kinoshita, Yuki Kondo, Yuka Sakazaki, Norio Takimoto, Yoichi Ishitsuka   +4 more
doaj   +2 more sources

5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II.
Stanislav Kalinin, Alexander Kovalenko, Annika Valtari, Alessio Nocentini, Maxim Gureev, Arto Urtti, Mikhail Korsakov, Claudiu T. Supuran, Mikhail Krasavin   +8 more
doaj   +2 more sources

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been
Claudia Melis, Rita Meleddu, Andrea Angeli, Simona Distinto, Giulia Bianco, Clemente Capasso, Filippo Cottiglia, Rossella Angius, Claudiu T. Supuran, Elias Maccioni   +9 more
doaj   +2 more sources

Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients

Clinical Ophthalmology, 2010
Adam M Moss, Alon Harris, Brent Siesky, Deepam Rusia, Kathleen M Williamson, Yochai ShoshaniDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USAAbstract: Topical hypotensive therapy with both timolol and carbonic
Adam M Moss, Alon Harris, Brent Siesky, et al   +3 more
doaj   +1 more source

Investigation into the Mechanism of Human Carbonic Anhydrase II [PDF]

, 2012
Human carbonic anhydrase II (HCAII) acts as a carbon dioxide sequestration catalyst, removing carbon dioxide from the blood stream and converting it into bicarbonate and a proton. The active site contains a tetrahedrally coordinated zinc atom coordinated
Saunders, Michael
core   +6 more sources

Quantitative Characterization of the Chemical Space Governed by Human Carbonic Anhydrases and selenium-containing derivatives of solfonamides [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2022
Due to the fact that different isoforms of carbonic anhydrase play distinct physiological roles, their diseases/disorders involvement are different as well.
Behnam Rasti
doaj   +1 more source

X-linked Juvenile Retinoschisis in a Young Female

Journal of Nepal Health Research Council, 2022
X-linked juvenile retinoschisis has recessive inheritance which occurs due to RS1 gene mutation. We report an instance in a female managed with systemic and topical carbonic-anhydrase inhibitors.
Sudha Ranabhat, Raghunandan Byanju, Simanta Khadka   +2 more
doaj   +1 more source

A clinical case of choroidal effusion associated with the use of carbonic anhydrase inhibitors

Офтальмохирургия, 2021
Relevance. Choroidal effusion is a complication accompanying both surgical interventions and ophthalmopathies of predominantly inflammatory etiology. The release of proteins from choriocapillaries lumen and decrease of intraocular pressure relative to ...
N. I. Kurysheva, O. A. Pererva, A. A. Ivanova, G. A. Sharova   +3 more
doaj   +1 more source

Collateral Changes in Cell Physiology Associated with ADC-7 β-Lactamase Expression in Acinetobacter baumannii

Microbiology Spectrum, 2023
The ADC (AmpC) β-lactamase is universally present in the Acinetobacter baumannii chromosome, suggesting it may have a yet-to-be-identified cellular function. Using peptidoglycan composition analysis, we show that overexpressing the ADC-7 β-lactamase in A.
Jennifer M. Colquhoun, Marjan Farokhyfar, Alexander C. Anderson, Christopher R. Bethel, Robert A. Bonomo, Anthony J. Clarke, Philip N. Rather   +6 more
doaj   +1 more source