Results 91 to 100 of about 23,970 (278)

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Anticancer evaluation of Myo-inositol through carbonic anhydrase IV inhibition activity: A spectroscopic, quantum computational, topological, drug-likeness and in-silico molecular docking studies

Results in Chemistry
Numerous inositol isomers, particularly myo-inositol, are beneficial in the treatment of polycystic ovary syndrome, diabetes, anxiety, and depression. This study established that myo-inositol has the potential to be utilized as a carbonic anhydrase IV ...
K. Rajkumar, V. Gokulakrishnan, S. Anand, R. Durga, G. Senthilkumar, S. Sri Karthick, R. Kayalvizhi Kothai   +6 more
doaj   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

SOME IN VITRO INHIBITORS OF CARBONIC ANHYDRASE

, 1958
Work on sulphonamides as in vitro inhibitors of carbonic anhydrase has been extended by the preparation and assay of novel types. Although diphenylsulphonamides, p-alkoxycarbonylbenzene sulphonamides and 5-alkoxycarbonylamino-1:3:4-thiadiazole-2-sulphon ...
V Petrow, B G Overell, O Stephenson, Y M Beasley   +3 more
core   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Activity of carbonic anhydrase inhibitors in breast cancer models.

, 2016
Evaluation of carbonic anhydrase inhibitors activity in breast cancer 2D and 3D ...
Želvytė, Aušra,
core  

Movement Disorders in Developmental and Epileptic Encephalopathies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Monogenic developmental and epileptic encephalopathies (DEE) frequently feature co‐occurring movement disorders. Gene discovery has expanded epilepsy‐dyskinesia syndromes (EDS) from classic associations such as stereotypies in Rett syndrome to PRRT2‐related infantile seizures with paroxysmal dyskinesia and crouched gait in SCN1A ...
Shekeeb Mohammad, Darius Ebrahimi‐Fakhari, Hugo Morales‐Briceno   +2 more
wiley   +1 more source

Evaluation of Benzenesulfonamide Derivatives; Quinazoline and Sulfonamide Selectively Targeting Carbonic Anhydrase XII for Tumor Microenvironment Modulation in Human Breast Cancer Cells

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Tumor cells evolve adaptive mechanisms to function optimally within an acidic microenvironment. This adaptation is driven by the enhanced metabolic activity of tumors, which frequently results in acidosis and hypoxia.
HIBA NABIL MIRAN, GHAITH ALI JASIM, TAREQ HAFDHI ABIDTAWFEEQ, AMMAR A. IBRAHIM AL-AZZAWI   +3 more
doaj   +1 more source

Carbonic Anhydrase IX Inhibitors: A Mini Review [PDF]

ERU Research Journal
Carbonic anhydrases inhibitors of human (h) (CA, EC 4.2.1.1) cytosolic isoforms hCA I and II, as well as transmembrane tumor-associated isoforms hCA IX and XII, we well illustrated isoforms hCA IX in details for all newly compounds have been synthesized ...
Mohamed Abdelrahman, Hadeer Ali, Mohamed Sayed   +2 more
doaj   +1 more source