Results 141 to 150 of about 22,853 (290)

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

Facile synthesis of aminobiphenyl sulfonamides via Chan-Lam coupling and their biological evaluation as potent carbonic anhydrase inhibitors. [PDF]

Sci Rep
Sharif M, Mahmood A, Kanwal A, Ahmad M, Rasool N, Qamar MU, Mughram MHA, Al-Harethi AAM, Shah TA, Shaikh II.   +9 more
europepmc   +1 more source

Recent Developments in Capillary and Microchip Electroseparations of Peptides (2023–mid 2025)

ELECTROPHORESIS, Volume 47, Issue 1, Page 106-136, January 2026.
ABSTRACT This review presents a comprehensive overview of the developments and applications of high‐performance capillary and microchip electromigration methods (zone electrophoresis in a free solution or in sieving media, isotachophoresis, isoelectric focusing, affinity electrophoresis, electrokinetic chromatography, and electrochromatography) for ...
Václav Kašička
wiley   +1 more source

Systemic Carbonic Anhydrase Inhibitors in Common Ophthalmic Diseases: A Scoping Review from A Clinical Standpoint. [PDF]

Curr Ophthalmol Rep
Hallaj S, Shalaby WS, Sinha S, Myers JS, Razeghinejad R.   +4 more
europepmc   +1 more source

The Impact of Aquaporin‐4 Deletion on K+‐Induced Astrocytic Swelling Depends on K+ Concentration

Glia, Volume 74, Issue 1, January 2026.
Swelling due to 10 mM [K+]o is reduced in astrocytes devoid of aquaporin‐4, while there is no difference between genotypes when exposed to 50 mM [K+]o. The two [K+]o concentrations induce distinct astrocytic Ca2+ signaling in the two genotypes pointing to a possible mechanistic basis of the differences observed. ABSTRACT Astrocytes swell in response to
Cecilie Bugge Bakketun, Lena Catherine Roth, Daniel Marelius Bjørnstad, Ole Petter Ottersen, Vidar Jensen, Rune Enger   +5 more
wiley   +1 more source

Hyaluronic Acid-Palmitate Nanoparticle Delivery of Carbonic Anhydrase Inhibitors Impairs Growth and Early Metabolism in <i>Escherichia coli</i> Through β- and γ-Carbonic Anhydrase-Associated Processes. [PDF]

Int J Mol Sci
De Luca V, Verdoliva V, Supuran CT, De Luca S, Capasso C.   +4 more
europepmc   +1 more source

Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors. [PDF]

J Enzyme Inhib Med Chem, 2023
Abdoli M, Bonardi A, Supuran CT, Žalubovskis R.   +3 more
europepmc   +1 more source

Arylsulfonamido-alkyl-sulfamates act as inhibitors of bovine carbonic anhydrase II

Toni C. Denner, Niels V. Heise, René Csük   +2 more
openalex   +1 more source

Discovery of Benzenesulfonamide Derivatives as Carbonic Anhydrase Inhibitors with Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Evaluation

, 2018
Chandra Bhushan Mishra, Shikha Kumari, Andrea Angeli, Silvia Bua, Manisha Tiwari, Claudiu T. Supuran   +5 more
openalex   +1 more source

Magnifying Glass on Sinonasal NUT Carcinoma Heterogeneity via Spatial Transcriptomics

Head &Neck, Volume 48, Issue 1, Page E1-E9, January 2026.
ABSTRACT Background Nuclear protein in testis (NUT) carcinomas (NCs) are rare, clinically aggressive tumors with characteristic translocation involving NUTM1 and BRD4 genes. While NCs are generally characterized by undifferentiated basaloid cells with focal/abrupt squamous differentiation, tumoral heterogeneity remains unexplored.
Diana Bell, Garret Choby, Michelle Afkhami, Ellie Maghami, Renata Ferrarotto, Carl Snyderman, Eric Wang, Ehab Hanna, Raja Seethala   +8 more
wiley   +1 more source