Results 161 to 170 of about 23,970 (278)

Retrospective Assessment of Carbonic Anhydrase Inhibitors in Topical or Episcleral Implant Form for the Treatment of Equine Glaucoma. [PDF]

Vet Ophthalmol
Tucker-Retter EK, Yamagata M, Gilger B, Oh A.   +3 more
europepmc   +1 more source

Th17 cells favor migration and invasiveness of cervical cancer cells under hypoxia in an IGF2BP2‐dependent manner

International Journal of Cancer, Volume 158, Issue 11, Page 3021-3037, 1 June 2026.
What's new? Hypoxic regions and inflammatory Th17 cells in the tumor environment are both associated with poor prognosis in cervical cancer. However, synergistic mechanisms between hypoxia and Th17 cells remain elusive. This study demonstrated Th17–hypoxia‐driven mechanisms underlying cervical cancer progression.
Selina Gies, Maike Pohlers, Tanja Tänzer, Emmanuel Ampofo, Matthias W. Laschke, Moritz Schäfer, Yoo‐Jin Kim, Rainer Maria Bohle, Erich‐Franz Solomayer, Konrad Wagner, Martin Empting, Alexandra K. Kiemer, Barbara Walch‐Rückheim   +12 more
wiley   +1 more source

Carbonic anhydrase inhibitors limit complications in X-linked retinoschisis. [PDF]

Front Med (Lausanne), 2023
Wey S, Brill DA, Miraldi Utz V, Sisk RA.
europepmc   +1 more source

Innovative Drug Delivery Systems for the Treatment of Glaucoma

MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
This review aims to provide a comprehensive overview of current topical drug delivery strategies for ocular hypotensive agents in glaucoma therapy. Additionally, it discusses the potential impact of emerging nanotechnological and biomaterial‐based systems in shaping the future of ophthalmic drug delivery, with an emphasis on enhancing efficacy, safety,
Jing Chu, Junzhi Li, Zhenlin Chen, Jinyu Zhang, Siqi Feng, Jiaying Huang, Yawen Chu, Xue Zhou, Wei Wang, Shangsi Chen   +9 more
wiley   +1 more source

Structure-Activity Relationship Studies for 1,3,4-Thiadiazole-Based Bacterial Carbonic Anhydrase Inhibitors with <i>In Vivo</i> Efficacy against Drug-Resistant <i>Neisseria gonorrhoeae</i>. [PDF]

J Med Chem
Tharra PR, Youse MS, Abutaleb NS, Abdelsattar AS, Holly KJ, Nocentini A, Abouelkhair AA, Metcalfe CK, Liao CJ, Thriumalaikumar VP, Ali F, Marapaka AK, Drummond FL, Snell OC, Supuran CT, Seleem MN, Flaherty DP.   +16 more
europepmc   +1 more source

Quantitative Competition Binding of Fluorinated Ligands by Real‐Time 19F In‐Cell NMR to Assess Isoform Selectivity in Human Cells

Magnetic Resonance in Chemistry, Volume 64, Issue 6, Page 584-593, June 2026.
Real‐time in‐cell 19F NMR spectroscopy in a flow NMR bioreactor was used to monitor the binding of fluorinated compounds to three cytosolic carbonic anhydrase isoforms in living human cells. The simultaneous observation of the two ligands allowed for the quantitative ranking of their intracellular affinities by competition binding. This approach allows
Azzurra Costantino, Letizia Barbieri, Simone Giovannuzzi, Alessio Nocentini, Claudiu T. Supuran, Enrico Luchinat   +5 more
wiley   +1 more source

Development of new anticancer thiadiazole-sulfonamides as dual EGFR/carbonic anhydrase inhibitors. [PDF]

Future Med Chem
Eissa IH, Elkady H, Elgammal WE, Mahdy HA, Elshennawy HS, Husein DZ, Amin FG, Ibrahim IM, Alsfouk BA, Elkaeed EB, Metwaly AM.   +10 more
europepmc   +1 more source

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, Volume 26, Issue 6, Page 9-21, June 2026.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

Facile synthesis of aminobiphenyl sulfonamides via Chan-Lam coupling and their biological evaluation as potent carbonic anhydrase inhibitors. [PDF]

Sci Rep
Sharif M, Mahmood A, Kanwal A, Ahmad M, Rasool N, Qamar MU, Mughram MHA, Al-Harethi AAM, Shah TA, Shaikh II.   +9 more
europepmc   +1 more source

Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors. [PDF]

J Enzyme Inhib Med Chem, 2023
Abdoli M, Bonardi A, Supuran CT, Žalubovskis R.   +3 more
europepmc   +1 more source