Results 181 to 190 of about 23,970 (278)

Hyaluronic Acid-Palmitate Nanoparticle Delivery of Carbonic Anhydrase Inhibitors Impairs Growth and Early Metabolism in <i>Escherichia coli</i> Through β- and γ-Carbonic Anhydrase-Associated Processes. [PDF]

Int J Mol Sci
De Luca V, Verdoliva V, Supuran CT, De Luca S, Capasso C.   +4 more
europepmc   +1 more source

T Cell Dysfunction in the Acidic Tumor Microenvironment

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Solid tumors are characterized by profound metabolic and vascular abnormalities that generate a hostile tumor microenvironment (TME) marked by extracellular acidosis, hypoxia, and nutrient deprivation. While the consequences of these conditions for cancer cell behavior have been extensively studied, their impact on anti‐tumor immune responses ...
F. B. Christiansen, E. S. Novella, A. V. Lindemann, J. F. H. Cordes, S. F. Pedersen   +4 more
wiley   +1 more source

Carbonic anhydrase inhibitors:

Journal of Enzyme Inhibition and Medicinal Chemistry, 2013
Derya Ekinci, Lutfi Karagoz, Deniz Ekinci, Murat Senturk, Claudiu T. Supuran   +4 more
openaire   +1 more source

Cerebral proteome adaptations to amyloid angiopathy are prevented by carbonic anhydrase inhibitors. [PDF]

Alzheimers Dement
Carlsen J, Fossati S, Østergaard L, Gutiérrez-Jiménez E, Palmfeldt J.   +4 more
europepmc   +1 more source

Functional and structural insights into cyanobacterial CO2 concentrating mechanisms: from compartmentalization to regulation

The Plant Journal, Volume 126, Issue 5, June 2026.
Significance Statement Life on Earth depends on photosynthetic CO2 fixation via the Calvin–Benson–Bassham cycle to form organic carbon. This process evolved first in cyanobacteria and was later conveyed to eukaryotes, giving rise to plastids in algae and plants. To cope with low atmospheric CO2 concentrations that developed over the course of evolution,
Erik Zimmer, Carolin Poppitz, Stephan Klähn, Khaled A. Selim   +3 more
wiley   +1 more source

Cascade-activatable NIR-II fluorescent carbonic anhydrase inhibitors for imaging-guided cuproptosis/chemodynamic combination therapy of colorectal cancer. [PDF]

Chem Sci
Xu P, Huang Y, Liu G, Gu X, Sun X, Bi Y, Zhou W, Xie C, Fan Q.   +8 more
europepmc   +1 more source

Privileged Scaffold Hybridization in the Design of Carbonic Anhydrase Inhibitors. [PDF]

Molecules
Secci D, Sanna E, Distinto S, Onali A, Lupia A, Demuru L, Atzeni G, Meleddu R, Cottiglia F, Angeli A, Supuran CT, Maccioni E.   +11 more
europepmc   +1 more source

Construction of a CO2‐Fixing Compartment Using a Shape‐Transforming DNA Scaffold

Chemistry – A European Journal, Volume 32, Issue 19, 22 May 2026.
A shape‐transforming DNA scaffold encapsulates RuBisCO within a controllable, self‐contacting compartment that mimics the carboxysome. The scaffold switches between open and closed states, enabling direct comparison of identical enzyme populations in different microenvironments.
Hui Yang, Peng Lin, Surachada Chuaychob, Huyen Dinh, Mei Nakabayashi, Eiji Nakata, Takashi Morii   +6 more
wiley   +1 more source

Hit-to-Lead Optimization of Acetazolamide-Based Bacterial Carbonic Anhydrase Inhibitors with Efficacy In Vivo for Treatment of Vancomycin-Resistant Enterococci Septicemia. [PDF]

J Med Chem
Holly KJ, Tharra PR, Abutaleb NS, Nocentini A, Abouelkhair AA, Youse MS, Marapaka AK, S Abdelsattar A, An W, Drummond FL, Snell OC, Supuran CT, Seleem MN, Flaherty DP.   +13 more
europepmc   +1 more source

Dual targeting carbonic anhydrase inhibitors as promising therapeutic approach: a structural overview. [PDF]

Front Mol Biosci
D'Ambrosio K, Di Fiore A, Langella E.
europepmc   +1 more source