Results 181 to 190 of about 648,149 (287)

Systemic Carbonic Anhydrase Inhibitors in Common Ophthalmic Diseases: A Scoping Review from A Clinical Standpoint. [PDF]

Curr Ophthalmol Rep
Hallaj S, Shalaby WS, Sinha S, Myers JS, Razeghinejad R.   +4 more
europepmc   +1 more source

Recent Advances in Microwave and Ultrasound Assisted Synthesis of Quinoline Derivatives as Anticancer Agents

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Green microwave‐ and ultrasound‐assisted synthesis enables the rapid, sustainable preparation of quinoline‐based anticancer agents with improved reaction efficiency, higher yields, and enhanced biological activity. ABSTRACT Quinoline derivatives represent a privileged class of heterocyclic compounds with remarkable structural diversity and broad ...
Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Ghanshyam Teli, Manjushree B V, Vipin K. Pandey, Shourya Pratap   +5 more
wiley   +1 more source

Computational, In Vitro, and In Vivo Evaluation of Benzimidazole–Pyrazole Hybrid Scaffolds as Multi‐Target Anti‐Ulcer Agents

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The hybrid pharmacophore approach involves the combination of benzimidazole‐pyrazole moieties to form multi‐functional anti‐ulcer compounds. Molecular modeling and biological evaluations show significant proton pump inhibition, anti‐inflammatory action, antioxidant property, and remarkable prevention of gastric ulcers.
Hafiz Aamir Ali Kharl, Abdul Malik, Humaira Nadeem, Mohammad Shamsul Ola, Sara Aiman, Arif Ullah Khan, Muhammad Akmal Farooq, Humaira Muzaffar, Syed Muzzammil Masaud   +8 more
wiley   +1 more source

Redesigning oxazolidinones as carbonic anhydrase inhibitors against vancomycin-resistant enterococci. [PDF]

Eur J Med Chem
Ammara A, Giovannuzzi S, Bonardi A, Abutaleb NS, Abouelkhair AA, Flaherty DP, Seleem MN, Capasso C, Gratteri P, Nocentini A, Supuran CT.   +10 more
europepmc   +1 more source

A Machine Learning Platform for Isoform-Specific Identification and Profiling of Human Carbonic Anhydrase Inhibitors. [PDF]

Pharmaceuticals (Basel)
Piazza L, Di Stefano M, Poles C, Bononi G, Poli G, Renzi G, Galati S, Giordano A, Macchia M, Carta F, Supuran CT, Tuccinardi T.   +11 more
europepmc   +1 more source

SHIP1 Restrains Hypoxia/Reoxygenation‐Induced Cytokine Secretion in Mouse Bone Marrow–Derived Mast Cells

European Journal of Immunology, Volume 56, Issue 9, September 2026.
(A) BMMCs are substantially more resistant to oxygen deprivation than neurons, microglia, oligodendrocytes, astrocytes, and fibroblasts. (B) Role of SHIP‐1 in primary mouse bone marrow mast cells’ hypoxia response. Under hypoxia, SHIP‐1 induces cytokine release. SHIP1 restrains hypoxia/reoxygenation‐induced cytokine secretion in BMMCs via the RAS/ RAF,
Lara Gubeljak, Jonas Pes, Eren Arik, Aaron T. Fehr, Mara Schietinger, Thomas Wilhelm, Sandro Capellman, Michael Huber, Pardes Habib   +8 more
wiley   +1 more source

Prescribing carbonic anhydrase inhibitors to patients with "sulfa" antibiotics allergy: do we dare? [PDF]

Eye (Lond)
Quintanilla R, van Leeuwen L, Sharma A, Chang TC, Hodapp E, McSoley J, Grajewski A, Bitrian E.   +7 more
europepmc   +1 more source

Stereoselective Construction of Benzo‐Fused Tetrahydropyrrole Thiazines From Saccharin

European Journal of Organic Chemistry, Volume 29, Issue 33, 1 September 2026.
Saccharin was used as a template to construct a series of 10a‐substituted, benzo‐fused, pyrrolo thiazinone dioxides. Thereafter, diastereo‐divergent 10‐keto reduction gave either diastereomeric alcohol in a process that did not rely on the substituent at 10a's identity.
Seanán Doyle, Matthew Kiernan, Jordan Smyth, Ajay Mathew, Conor J. Crawford, Julia Bruno‐Colmenarez, Patrick J. Guiry, Aisha Khalifa, Paul Evans   +8 more
wiley   +1 more source

Cerebral proteome adaptations to amyloid angiopathy are prevented by carbonic anhydrase inhibitors. [PDF]

Alzheimers Dement
Carlsen J, Fossati S, Østergaard L, Gutiérrez-Jiménez E, Palmfeldt J.   +4 more
europepmc   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, Volume 58, Issue 5, Page 1396-1412, September 2026.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source