Results 171 to 180 of about 648,149 (287)

Retrospective Assessment of Carbonic Anhydrase Inhibitors in Topical or Episcleral Implant Form for the Treatment of Equine Glaucoma. [PDF]

Vet Ophthalmol
Tucker-Retter EK, Yamagata M, Gilger B, Oh A.   +3 more
europepmc   +1 more source

Carbonic anhydrase inhibitors limit complications in X-linked retinoschisis. [PDF]

Front Med (Lausanne), 2023
Wey S, Brill DA, Miraldi Utz V, Sisk RA.
europepmc   +1 more source

From Identification to Enzymatic Activity Profiling: Comprehensive Characterization of BloCAβ, a Probiotic β‐Carbonic Anhydrase From Bifidobacterium longum

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
Production and biochemical characterization of a new β‐carbonic anhydrase from the probiotic Bifidobacterium longum, one of the main players of human gut microbiota. ABSTRACT The microbiota comprises communities of microorganisms that establish complex relationships with the host and play key roles in physiology, metabolism, and immunity.
Simone Giovannuzzi, Andrea Ammara, Simone Carradori, Viviana De Luca, Marialucia Gallorini, Damiano Iacovozzi, Amelia Cataldi, Ilaria D'Agostino, Davide Moi, Valentina Onnis, Claudiu T. Supuran, Clemente Capasso   +11 more
wiley   +1 more source

Structure-Activity Relationship Studies for 1,3,4-Thiadiazole-Based Bacterial Carbonic Anhydrase Inhibitors with <i>In Vivo</i> Efficacy against Drug-Resistant <i>Neisseria gonorrhoeae</i>. [PDF]

J Med Chem
Tharra PR, Youse MS, Abutaleb NS, Abdelsattar AS, Holly KJ, Nocentini A, Abouelkhair AA, Metcalfe CK, Liao CJ, Thriumalaikumar VP, Ali F, Marapaka AK, Drummond FL, Snell OC, Supuran CT, Seleem MN, Flaherty DP.   +16 more
europepmc   +1 more source

Fragment‐Based Screening of Heterocyclic Electrophiles Identified Acrylamide Bioisoteres for Covalent KRasG12C Inhibitors

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
We screened acrylamide bioisosteres against KRasG12C and prioritized primary hits by their GSH reactivity, labeling efficiency and specificity. The most promising fragment was combined with a KRas‐binding scaffold. Covalent binding, inhibitory activity and selectivity were confirmed via MS, NMR, biochemical and cell viability assays.
Nikolett Péczka, Aaron Keeley, Péter Ábrányi‐Balogh, Zoltán Orgován, László Petri, Emma K. Grant, Chad Quinn, Soma Csanády, Ivan Randelovic, József Tóvári, Jacob Bush, György M. Keserű   +11 more
wiley   +1 more source

Development of new anticancer thiadiazole-sulfonamides as dual EGFR/carbonic anhydrase inhibitors. [PDF]

Future Med Chem
Eissa IH, Elkady H, Elgammal WE, Mahdy HA, Elshennawy HS, Husein DZ, Amin FG, Ibrahim IM, Alsfouk BA, Elkaeed EB, Metwaly AM.   +10 more
europepmc   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1961-1974, September 2026.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Facile synthesis of aminobiphenyl sulfonamides via Chan-Lam coupling and their biological evaluation as potent carbonic anhydrase inhibitors. [PDF]

Sci Rep
Sharif M, Mahmood A, Kanwal A, Kanwal A, Ahmad M, Rasool N, Qamar MU, Mughram MHA, Al-Harethi AAM, Shah TA, Shaikh II.   +10 more
europepmc   +1 more source

Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors. [PDF]

J Enzyme Inhib Med Chem, 2023
Abdoli M, Bonardi A, Supuran CT, Žalubovskis R.   +3 more
europepmc   +1 more source

Combining Phytochemical and Computational Approach on Citrus hystrix DC. (Kaffir Lime) Peel Extract: Anti‐Diabetic and Anti‐Inflammatory Activities

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Citrus hystrix DC. (kaffir lime) peel was dried and subjected to ethanolic extract. The GC‐MS analysis showed the presence of significant phyto‐ingredients. Pharmacokinetic and ADMET filters were applied to major constituents, and molecular docking, Gene Ontology (GO), and KEGG pathway enrichment analyses on mechanistic plausibility were also performed.
Malathy Soundara Rajan, Sankarganesh Palaniyandi, Swetha Sunkar   +2 more
wiley   +1 more source