Results 11 to 20 of about 22,853 (290)
Frontiers in Chemistry, 2021 A series of novel 1H-1,2,3-triazole analogs (9a–j) were synthesized via “Click” chemistry and Suzuki–Miyaura cross-coupling reaction in aqueous medium. The compounds were evaluated for their carbonic anhydrase-II enzyme inhibitory activity in vitro.
Satya Kumar Avula +8 more
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5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II.
Stanislav Kalinin +8 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111.
Mazin A. A. Najm +7 more
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The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Cardiovascular diseases are the leading cause of mortality worldwide. In recent years, the relationship between carbonic anhydrase inhibitors and atherosclerosis has attracted attention.
Onur Argan +3 more
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Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I
Oftalʹmologiâ, 2020 Glaucoma is the main cause of irreversible blindness in the world. Carbonic anhydrase inhibitors (CAIS) used both systemically and topically, reduce intraocular pressure effectively.
N. I. Kurysheva
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Bioinformatics Tools for the Analysis of Active Compounds Identified in Ranunculaceae Species
Pharmaceuticals, 2023 The chemical compounds from extracts of three Ranunculaceae species, Aconitum toxicum Rchb., Anemone nemorosa L. and Helleborus odorus Waldst. & Kit.
Cătălina Mareş +3 more
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Management of glaucoma in pregnancy: risks or choices, a dilemma? [PDF]
International Journal of Ophthalmology, 2016 The treatment of glaucoma in and around pregnancy offers the unique challenge of balancing the risk of vision loss to the mother as against the potential harm to the fetus or newborn. Most anti-glaucoma drugs (i.e. beta-blockers, prostaglandin analogues,
Harinder Singh Sethi +2 more
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Dithiocarbamates effectively inhibit the α-carbonic anhydrase from Neisseria gonorrhoeae
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Recently, inorganic anions and sulphonamides, two of the main classes of zinc-binding carbonic anhydrase inhibitors (CAIs), were investigated for inhibition of the α-class carbonic anhydrase (CA, EC 4.2.1.1) from Neisseria gonorrhoeae, NgCA.
Simone Giovannuzzi +7 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 In search of selective carbonic anhydrase (CA) IX inhibitors endowed with apoptotic inducing properties, we designed and synthesised two subsets of 4- and 3-(5-aryl-(4-phenylsulphonyl)-1H-1,2,3-triazol-1-yl)benzenesulphonamides.
Kiran Siwach +7 more
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Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been
Claudia Melis +9 more
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