Results 231 to 240 of about 42,138 (273)

Carbonic Anhydrase Inhibitors Drug Design

2013
Inhibition of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) has pharmacologic applications in the field of antiglaucoma, anticonvulsant, antiobesity, and anticancer agents but is also emerging for designing anti-infectives (antifungal and antibacterial agents) with a novel mechanism of action. As a consequence, the drug design of CA inhibitors (
Robert, McKenna, Claudiu T, Supuran
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Patient Tolerance to Carbonic Anhydrase Inhibitors

American Journal of Ophthalmology, 1978
We evaluated carbonic anhydrase inhibitors in a crossover study with a placebo and random allocation of treatment administration. Drugs evaluated included acetazolamide tablets and Sequels, dichlorphenamide, ethoxzolamide, methazolamide, and an ascorbic acid placebo. The best tolerated drug was acetazolamide Sequels. Methazolamide was next.
P R, Lichter, L P, Newman, N C, Wheeler, O V, Beall   +3 more
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Boron-containing carbonic anhydrases inhibitors

Bioorganic Chemistry
Over the last decades, the medicinal chemistry of boron-based compounds has been extensively explored, designing valuable small molecule drugs to tackle diseases and conditions, such as cancer, infections, inflammatory and neurological disorders.
Giovannuzzi, Simone, Nikitjuka, Anna, Pereira Resende, Bruna Rafaela, Smietana, Michael, Nocentini, Alessio, Supuran, Claudiu T., Winum, Jean-Yves   +6 more
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Hydroxyurea is a carbonic anhydrase inhibitor

Bioorganic & Medicinal Chemistry, 2003
The interaction of hydroxyurea with the cytosolic isozymes of carbonic anhydrase (CA), hCA I and hCA II has been investigated by means of kinetic and spectroscopic techniques. Hydroxyurea acts as a weak, non-competitive inhibitor of both isozymes, for the 4-nitrophenyl acetate esterase activity, with inhibition constants around 0.1 mM for both isozymes.
SCOZZAFAVA, ANDREA, SUPURAN, CLAUDIU TRANDAFIR   +1 more
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Safety of carbonic anhydrase inhibitors

Expert Opinion on Drug Safety, 2014
Carbonic anhydrase (CA) inhibitors have an impressive safety record despite the multiple functions that CA isozymes serve because they are not fully inhibited with most dosing. While reducing the targeted CA-dependent process sufficiently for disease control, residual activity and uncatalyzed rates in combination with compensations are adequate to ...
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Carbonic anhydrase inhibitor in trout plasma

Respiration Physiology, 1976
A manometric assay has been constructed such that carbonic anhydrase dehydration activity can be determined utilizing intact erythrocytes. It was found that unwashed whole trout blood lacks any dehydration activity quite in contrast to whole rat blood.
M S, Haswell, D J, Randall
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CARBONIC ANHYDRASE INHIBITORS

Pharmacological Reviews, 1956
R W, BERLINER, J, ORLOFF
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Carbonic anhydrase inhibitors

Bioorganic & Medicinal Chemistry, 1999
Joaquin Borras, Andrea Scozzafava, Luca Menabuoni, Francesco Mincione, Fabrizio Briganti, Giovanna Mincione, Claudiu T. Supuran   +6 more
openaire   +1 more source

Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology

Physiological Reviews, 2022
Ashok Aspatwar, Harlan R Barker, Susanna Valanne   +2 more
exaly  

Carbonic Anhydrase Inhibitors

Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents, 2001
Claudiu Supuran, Andrea Scozzafava
openaire   +1 more source