Results 21 to 30 of about 42,138 (273)

5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2022
Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II.
Stanislav Kalinin   +8 more
doaj   +1 more source

Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2022
The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111.
Mazin A. A. Najm   +7 more
doaj   +1 more source

The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cardiovascular diseases are the leading cause of mortality worldwide. In recent years, the relationship between carbonic anhydrase inhibitors and atherosclerosis has attracted attention.
Onur Argan   +3 more
doaj   +1 more source

Role of carbon dioxide and ion transport in the formation of sub-embryonic fluid by the blastoderm of the Japanese quail [PDF]

open access: yes, 2002
1. The explanted blastoderm of the Japanese quail was used to explore the role of ions and carbon dioxide in determining the rate of sub-embryonic fluid (SEF) production between 54 and 72 h of incubation. 2.
AR A.   +27 more
core   +1 more source

Preclinical Evaluation of Ureidosulfamate Carbonic Anhydrase IX/XII Inhibitors in the Treatment of Cancers [PDF]

open access: yes, 2019
Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Upregulation of the CAIX/XII isoforms is associated with hypoxic tumours and clinically linked with malignant progression, treatment ...
Gieling, Roben, Williams, Kaye J.
core   +2 more sources

Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I

open access: yesOftalʹmologiâ, 2020
Glaucoma is the main cause of irreversible blindness in the world. Carbonic anhydrase inhibitors (CAIS) used both systemically and topically, reduce intraocular pressure effectively.
N. I. Kurysheva
doaj   +1 more source

A glycosylphosphatidylinositol-anchored carbonic anhydrase-related protein of Toxoplasma gondii is important for rhoptry biogenesis and virulence [PDF]

open access: yes, 2017
Carbonic anhydrase-related proteins (CARPs) have previously been described as catalytically inactive proteins closely related to α-carbonic anhydrases (α-CAs).
Beejan Asady   +7 more
core   +2 more sources

Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N -Diethyl-Substituted AmidoMoieties [PDF]

open access: yes, 2012
Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities.
Ajani, Olayinka O.   +4 more
core   +9 more sources

Bioinformatics Tools for the Analysis of Active Compounds Identified in Ranunculaceae Species

open access: yesPharmaceuticals, 2023
The chemical compounds from extracts of three Ranunculaceae species, Aconitum toxicum Rchb., Anemone nemorosa L. and Helleborus odorus Waldst. & Kit.
Cătălina Mareş   +3 more
doaj   +1 more source

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold [PDF]

open access: yes, 2019
A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1).
Akdemir, A.   +11 more
core   +2 more sources

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