Results 21 to 30 of about 42,138 (273)

5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II.
Stanislav Kalinin, Alexander Kovalenko, Annika Valtari, Alessio Nocentini, Maxim Gureev, Arto Urtti, Mikhail Korsakov, Claudiu T. Supuran, Mikhail Krasavin   +8 more
doaj   +1 more source

Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111.
Mazin A. A. Najm, Walaa R. Mahmoud, Azza T. Taher, Safinaz E-S. Abbas, Fadi M. Awadallah, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran   +7 more
doaj   +1 more source

The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cardiovascular diseases are the leading cause of mortality worldwide. In recent years, the relationship between carbonic anhydrase inhibitors and atherosclerosis has attracted attention.
Onur Argan, Kübra Çıkrıkçı, Aybike Baltacı, Nahit Gencer   +3 more
doaj   +1 more source

Role of carbon dioxide and ion transport in the formation of sub-embryonic fluid by the blastoderm of the Japanese quail [PDF]

, 2002
1. The explanted blastoderm of the Japanese quail was used to explore the role of ions and carbon dioxide in determining the rate of sub-embryonic fluid (SEF) production between 54 and 72 h of incubation. 2.
AR A., BABIKER E.M., BECKER WA., BENOS DJ., BORON W.F., BRAKE J., COTTERILI O.J., DODGSON S.J., DODGSON S.J., EHRENFELD J., FRITSCHE C., HANSSON H.P.J., MAHEN T.H., MAREN T.H., MUELLER W.J., NEW D.A.T., NEW D.A.T., REUSS L., ROMANOFF A.L., ROMANOFF A.L., SIMKISS K., SOKAL R.R., STERN C.D., STERN C.D., TAYLOR L.W., TAYLOR L.W., WALSH T.J., ZEUTHEN T.   +27 more
core   +1 more source

Preclinical Evaluation of Ureidosulfamate Carbonic Anhydrase IX/XII Inhibitors in the Treatment of Cancers [PDF]

, 2019
Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Upregulation of the CAIX/XII isoforms is associated with hypoxic tumours and clinically linked with malignant progression, treatment ...
Gieling, Roben, Williams, Kaye J.
core   +2 more sources

Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I

Oftalʹmologiâ, 2020
Glaucoma is the main cause of irreversible blindness in the world. Carbonic anhydrase inhibitors (CAIS) used both systemically and topically, reduce intraocular pressure effectively.
N. I. Kurysheva
doaj   +1 more source

A glycosylphosphatidylinositol-anchored carbonic anhydrase-related protein of Toxoplasma gondii is important for rhoptry biogenesis and virulence [PDF]

, 2017
Carbonic anhydrase-related proteins (CARPs) have previously been described as catalytically inactive proteins closely related to α-carbonic anhydrases (α-CAs).
Beejan Asady, Isabelle Coppens, Jessica C. Kissinger, Leandro Lemgruber, Nathan M. Chasen, Rossiane C. Vommaro, Silvia N. J. Moreno, William J. Sullivan   +7 more
core   +2 more sources

Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N -Diethyl-Substituted AmidoMoieties [PDF]

, 2012
Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities.
Ajani, Olayinka O., Echeme, Johnbull O, Familoni, Oluwole B, Sujiang, Zheng, Wu, Feipeng   +4 more
core   +9 more sources

Bioinformatics Tools for the Analysis of Active Compounds Identified in Ranunculaceae Species

Pharmaceuticals, 2023
The chemical compounds from extracts of three Ranunculaceae species, Aconitum toxicum Rchb., Anemone nemorosa L. and Helleborus odorus Waldst. & Kit.
Cătălina Mareş, Ana-Maria Udrea, Nicoleta Anca Şuţan, Speranţa Avram   +3 more
doaj   +1 more source

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold [PDF]

, 2019
A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1).
Akdemir, A., Amoroso, R., Angeli, A., Carradori, S., Cirilli, R., De Filippis, B., De Monte, C., Guglielmi, P., Maccallini, C., Rotondi, G., Secci, D., Supuran, C. T.   +11 more
core   +2 more sources