Novel thiazolone-benzenesulphonamide inhibitors of human and bacterial carbonic anhydrases. [PDF]
J Enzyme Inhib Med Chem, 2023 A small library of novel thiazolone-benzenesulphonamides has been prepared and evaluated for their ability to inhibit three human cytosolic carbonic anhydrases (hCA I, hCA II, and hCA VII) and three bacterial carbonic anhydrases (MscCAβ, StCA1, and StCA2)
Abdoli M +4 more
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Carbonic Anhydrases and Metabolism [PDF]
Metabolites, 2018 Although the role of carbonic anhydrases (CAs, EC 4.2.1.1) in metabolism is well-established, pharmacological applications of this phenomenon started to be considered only recently.
Claudiu T. Supuran
doaj +4 more sources
1,2,3-Benzoxathiazine-2,2-dioxides - effective inhibitors of human carbonic anhydrases. [PDF]
J Enzyme Inhib Med Chem, 2023 A series of 1,2,3-benzoxathiazine-2,2-dioxides possessing various substituents in the 5, 7, or 8 position was obtained from corresponding 2-hydroxybenzaldehydes in their reaction with sulfamoyl chloride.
Ivanova J +4 more
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Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates. [PDF]
J Enzyme Inhib Med Chem, 2023 Carbonic anhydrases (CAs) from the pathogenic bacteria Nesseria gonorrhoeae and vancomycin-resistant enterococci (VRE) have recently been validated as antibacterial drug targets. Here we explored the inhibition of the α-CA from N.
Giovannuzzi S +9 more
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Carbonic Anhydrases: Different Active Sites, Same Metal Selectivity Rules. [PDF]
MoleculesCarbonic anhydrases are mononuclear metalloenzymes catalyzing the reversible hydration of carbon dioxide in organisms belonging to all three domains of life.
Kircheva N, Angelova S, Dudev T.
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Acipimox inhibits human carbonic anhydrases. [PDF]
J Enzyme Inhib Med Chem, 2022 Acipimox, a nicotinic acid derivative in clinical use for the treatment of hyperlipidaemia, incorporates a free carboxylic acid and an N-oxide moiety, functionalities known to interact with the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) and ...
Mori M, Supuran CT.
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CARBONIC ANHYDRASE IN MOLLUISCS
The Biological Bulletin, 1948 Carbonic anhydrase has been demonstrated in the mantle tissues and body fluids of most of 12 species of pelecypods and 8 species of gastropods.
John A. Freeman, Karl M. Wilbur
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Roles of Carbonic Anhydrases and Carbonic Anhydrase Related Proteins in Zebrafish. [PDF]
Int J Mol Sci, 2022 During the last decades, zebrafish (Danio rerio) has become one of the most important model organisms to study different physiological and biological phenomena. Research field of carbonic anhydrases (CAs) and carbonic anhydrase related proteins (CARPs) is not an exception in this.
Aspatwar A, Syrjänen L, Parkkila S.
europepmc +5 more sources
Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer. [PDF]
Breast Cancer Res, 2023 Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing.
Lee S +13 more
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Coumarins effectively inhibit bacterial α-carbonic anhydrases. [PDF]
J Enzyme Inhib Med Chem, 2022 Coumarins are known to act as prodrug inhibitors of mammalian α-carbonic anhydrases (CAs, EC 4.2.1.1) but they were not yet investigated for the inhibition of bacterial α-CAs.
Giovannuzzi S +5 more
europepmc +2 more sources