Results 91 to 100 of about 41,221 (304)

The Effect of Nanoparticles on the Structure and Enzymatic Activity of Human Carbonic Anhydrase I and II

Molecules, 2020
Human carbonic anhydrases (hCAs) belong to a well characterized group of metalloenzymes that catalyze the conversion of carbonic dioxide into bicarbonate.
Celia Cabaleiro-Lago, Martin Lundqvist
doaj   +1 more source

Legionella pneumophila Carbonic Anhydrases: Underexplored Antibacterial Drug Targets

Pathogens, 2016
Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes which catalyze the hydration of carbon dioxide to bicarbonate and protons. Many pathogenic bacteria encode such enzymes belonging to the α-, β-, and/or γ-CA families.
Claudiu T. Supuran
doaj   +1 more source

Primary mono- and bis-sulfonamides obtained via regiospecific sulfochlorination of N-arylpyrazoles: inhibition profile against a panel of human carbonic anhydrases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
A diverse set of mono- and bis-sulfonamide was obtained via a direct, chemoselective sulfochlorination of readily available yet hitherto unexplored N-arylpyrazole template.
Mikhail Krasavin, Mikhail Korsakov, Oksana Ronzhina, Tiziano Tuccinardi, Stanislav Kalinin, Muhammet Tanç, Claudiu T. Supuran   +6 more
doaj   +1 more source

Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Here, we report a toxicity study, conducted on zebrafish larvae, of a series of coumarin and sulfamide compounds that were previously reported as inhibitors of human (h) metalloenzymes, carbonic anhydrases (CAs, EC 4.2.1.1).
Ashok Aspatwar, Emanuela Berrino, Silvia Bua, Fabrizio Carta, Clemente Capasso, Seppo Parkkila, Claudiu T. Supuran   +6 more
doaj   +1 more source

Breaking barriers: Smart vaccine platforms for cancer immunomodulation

Cancer Communications, EarlyView.
Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines. Leveraging the immune system's natural ability to target and kill cancer cells holds great therapeutic potential ...
Mohammad Mahmoudi Gomari, Taha Ghantabpour, Nima Pourgholam, Neda Rostami, Stephen M. Hatfield, Farzaneh Namazifar, Shadi Abkhiz, Seyed Sadegh Eslami, Mahsa Ramezanpour, Mahsa Darestanifarahani, Igor Astsaturov, Sidi A. Bencherif    +11 more
wiley   +1 more source

Magnetism in Carbon Structures [PDF]

, 2004
We discuss different magnetic phenomena observed in carbon-based structures, in particular the diamagnetism, paramagnetism and ferromagnetism observed in graphite, disordered carbon, fullerenes and irradiated carbon structures.
arxiv   +1 more source

Cucurbit[7]uril‐Styryl Dye Complexes for Fluorescent Recognition of DNA and Cell Imaging

ChemBioChem, EarlyView.
Recognition properties in solution and in cancer cells: a two dicationic cyanine dyes with different functionalities were developed and studied for their fluorescent properties, cytotoxicity and cellular imaging. The effect of encapsulation was checked using synthetic molecular container of cucurbit[7]uril.
Ekaterina Y. Chernikova, Maria A. Ustimova, Yuri V. Fedorov, Polina A. Chernikova, Ivan A. Godovikov, Nelly S. Chmelyuk, Maxim A. Abakumov, Olga A. Fedorova   +7 more
wiley   +1 more source

Factors associated with the early emergence of atypical feeding behaviours in infants and young children: A scoping review

Child: Care, Health and Development, Volume 49, Issue 1, Page 1-19, January 2023., 2023
Abstract Background Atypical feeding behaviours such as significantly limited food preferences, hypersensitivity to food textures or temperatures and pocketing food without swallowing are common concerns in child health. Current reports indicate an inter‐relationship between early growth, feeding problems and developmental disorders, yet little is ...
Asmita Mudholkar, Larissa Korostenski, Dianne Blackwell, Alison E. Lane   +3 more
wiley   +1 more source

Carbonic Anhydrases: Role in pH Control and Cancer

Metabolites, 2018
The pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of new ...
Mam Y. Mboge, Brian P. Mahon, Robert McKenna, Susan C. Frost   +3 more
doaj   +1 more source

Designing Enzymatic Reactivity with an Expanded Palette

ChemBioChem, EarlyView.
Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley   +1 more source