Results 121 to 130 of about 27,386 (335)
4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases
Molecules, 2014 A series of N-aryl-β-alanine derivatives and diazobenzenesulfonamides containing aliphatic rings were designed, synthesized, and their binding to carbonic anhydrases (CA) I, II, VI, VII, XII, and XIII was studied by the fluorescent thermal shift assay ...
Kęstutis Rutkauskas +12 more
doaj +1 more source
The structure of a tetrameric α-carbonic anhydrase fromThermovibrio ammonificansreveals a core formed around intermolecular disulfides that contribute to its thermostability [PDF]
, 2014 Carbonic anhydrase enzymes catalyse the reversible hydration of carbon dioxide to bicarbonate. A thermophilic Thermovibrio ammonificans α-carbonic anhydrase (TaCA) has been expressed in Escherichia coli and structurally and biochemically characterized ...
Berg, Svein +7 more
core +1 more source
Epilepsia, EarlyView.Abstract Objective Topiramate has been linked to increased glaucoma risk, potentially through mechanisms involving ocular fluid shifts. However, comparative risks vs other antiseizure medications (ASMs) and variation by sex or indication remain uncertain.
Cuiling Wei +10 more
wiley +1 more source
Early alterations on photosynthesis-related parameters in Chlamydomonas reinhardtii cells exposed to atrazine: A multiple approach study [PDF]
, 2016 Chlamydomonas reinhardtii cells were exposed to a sublethal concentration of thewidespread herbicide atrazine for 3 h. Physiological cellular parameters, such as chlorophyll a fluorescence and oxidative stress monitored by flow cytometry and pigments ...
Cid, Ángeles +4 more
core +2 more sources
Environmental Toxicology and Chemistry, EarlyView.Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers +10 more
wiley +1 more source
Peptide-Gold Nanoparticle Conjugates as Artificial Carbonic Anhydrase Mimics [PDF]
, 2019 We herein describe the design and synthesis of a catalytically active peptide–gold nanoparticle conjugate (Pep-Au-NP) that binds Zn(II) within its peptide monolayer and develops carbonic anhydrase activity. Specifically, a modified variant of the β-sheet
Koksch, Beate, Mikolajczak, Dorian J.
core +1 more source
Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies [PDF]
, 2022 Virginia Pontecorvi +12 more
openalex +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka +4 more
wiley +1 more source
Protective role of carbonic anhydrases III and VII in cellular defense mechanisms upon redox unbalance [PDF]
, 2018 Under oxidative stress conditions, several constitutive cellular defense systems are activated, which involve both enzymatic systems and molecules with antioxidant properties such as glutathione and vitamins.
De Simone, Giuseppina +4 more
core +1 more source
International Journal of Cancer, EarlyView.What's New? Hypoxic regions and inflammatory Th17 cells in the tumor environment are both associated with poor prognosis in cervical cancer. However, synergistic mechanisms between hypoxia and Th17 cells remain elusive. This study demonstrated Th17–hypoxia‐driven mechanisms underlying cervical cancer progression.
Selina Gies +12 more
wiley +1 more source