Results 121 to 130 of about 41,221 (304)
Bacterial carbonic anhydrases as drug targets: towards novel antibiotics ?
Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes which catalyze the hydration of carbon dioxide to bicarbonate and protons. Many pathogenic bacteria encode such enzymes belonging to the a-, b-, and/or g-CA families.
Claudiu T. Supuran
doaj +1 more source
ABSTRACT Posttraumatic osteoarthritis (PTOA) is a common sequela to anterior cruciate ligament (ACL) injury in humans and dogs. Identification of conserved targets between species may hasten biomarker identification and therapeutic development. To identify differentially regulated synovial fluid (SF) proteins in ACL injury, SF samples were collected ...
Sydney J. Womack+4 more
wiley +1 more source
Carbon dioxide to carbon nanotube scale-up [PDF]
Team C2CNT, or team Carbon dioxide to carbon nanotubes, proprietary technology directly removes the widest range of carbon dioxide from the ecosystem. C2CNT technology simply transforms low to high carbon dioxide into carbon and oxygen, and the carbon produced is permanently removed, that is stable on the order of geologic time frames. C2CNT technology
arxiv
Abstract Ocean alkalinity enhancement (OAE) is a widely considered marine CO2 removal method. Ocean alkalinity enhancement works by converting seawater CO2 into HCO3−$$ {\mathrm{HCO}}_3^{-} $$ and CO32−$$ {\mathrm{CO}}_3^{2-} $$ by electrochemical methods or the addition of alkaline minerals.
Damon Britton+2 more
wiley +1 more source
Calculating the energy profile of an enzymatic reaction on a quantum computer [PDF]
Quantum computing (QC) provides a promising avenue toward enabling quantum chemistry calculations, which are classically impossible due to a computational complexity that increases exponentially with system size. As fully fault-tolerant algorithms and hardware, for which an exponential speedup is predicted, are currently out of reach, recent research ...
arxiv
Abstract The formation of initial bivalve shell is sensitive to ocean acidification, encoding the basis of shell formation and environmental information. Here, we demonstrated how the initial shell building processes were affected under various acidified conditions.
Yang Xu+4 more
wiley +1 more source
Abstract PSBO is essential for the assembly of the oxygen‐evolving complex in plants and green algae. Despite its importance, we lack essential information on its lifetime and how it depends on the environmental conditions. We have generated nitrate‐inducible PSBO amiRNA lines in the green alga Chlamydomonas reinhardtii.
André Vidal‐Meireles+6 more
wiley +1 more source
Guiding Generative Protein Language Models with Reinforcement Learning [PDF]
Autoregressive protein language models (pLMs) have emerged as powerful tools to efficiently design functional proteins with extraordinary diversity, as evidenced by the successful generation of diverse enzyme families, including lysozymes or carbonic anhydrases.
arxiv
The Sunk Carbon Fallacy: Rethinking Carbon Footprint Metrics for Effective Carbon-Aware Scheduling [PDF]
The rapid increase in computing demand and its corresponding energy consumption have focused attention on computing's impact on the climate and sustainability. Prior work proposes metrics that quantify computing's carbon footprint across several lifecycle phases, including its supply chain, operation, and end-of-life.
arxiv +1 more source