Novel thiazolone-benzenesulphonamide inhibitors of human and bacterial carbonic anhydrases [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 A small library of novel thiazolone-benzenesulphonamides has been prepared and evaluated for their ability to inhibit three human cytosolic carbonic anhydrases (hCA I, hCA II, and hCA VII) and three bacterial carbonic anhydrases (MscCAβ, StCA1, and StCA2)
Morteza Abdoli +4 more
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Acipimox inhibits human carbonic anhydrases [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Acipimox, a nicotinic acid derivative in clinical use for the treatment of hyperlipidaemia, incorporates a free carboxylic acid and an N-oxide moiety, functionalities known to interact with the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) and ...
Mattia Mori, Claudiu T. Supuran
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1,2,3-Benzoxathiazine-2,2-dioxides – effective inhibitors of human carbonic anhydrases [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 A series of 1,2,3-benzoxathiazine-2,2-dioxides possessing various substituents in the 5, 7, or 8 position was obtained from corresponding 2-hydroxybenzaldehydes in their reaction with sulfamoyl chloride.
Jekaterina Ivanova +4 more
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Carbonic Anhydrases: Different Active Sites, Same Metal Selectivity Rules [PDF]
MoleculesCarbonic anhydrases are mononuclear metalloenzymes catalyzing the reversible hydration of carbon dioxide in organisms belonging to all three domains of life.
Nikoleta Kircheva +2 more
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Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Carbonic anhydrases (CAs) from the pathogenic bacteria Nesseria gonorrhoeae and vancomycin-resistant enterococci (VRE) have recently been validated as antibacterial drug targets. Here we explored the inhibition of the α-CA from N.
Simone Giovannuzzi +9 more
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Coumarins effectively inhibit bacterial α-carbonic anhydrases [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Coumarins are known to act as prodrug inhibitors of mammalian α-carbonic anhydrases (CAs, EC 4.2.1.1) but they were not yet investigated for the inhibition of bacterial α-CAs.
Simone Giovannuzzi +5 more
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Investigation on N-Aryl-2-(4-sulfamoylphenyl)hydrazine-1-carbothioamide as Human Carbonic Anhydrases Inhibitors [PDF]
PharmaceuticalsBackground: Among the 15 human (h) carbonic anhydrase (CA; EC 4.2.1.1) isoforms, hCA IX and XII are particularly important due to their roles in tumor cell growth and survival, identifying them as promising targets for anticancer therapy.
Morteza Abdoli +7 more
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Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine setting of oxygen/glucose deprivation followed by re-oxygenation and is associated with improved neuronal function in ischemic rats [PDF]
HeliyonCarbonic anhydrases constitute a family of metalloenzymes vital for maintaining acid-base balance and regulating pH in physio-pathological processes. These findings suggest carbonic anhydrases as potential therapeutic targets for treating pH-associated ...
Sara Amiranda +13 more
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Inhibition studies of bacterial α-carbonic anhydrases with phenols [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 The α-class carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogens Neisseria gonorrhoeae (NgCAα) and Vibrio cholerae (VchCAα) were investigated for their inhibition by a panel of phenols and phenolic acids.
Simone Giovannuzzi +6 more
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Quantitative Characterization of the Chemical Space Governed by Human Carbonic Anhydrases and selenium-containing derivatives of solfonamides [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2022 Due to the fact that different isoforms of carbonic anhydrase play distinct physiological roles, their diseases/disorders involvement are different as well.
Behnam Rasti
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