Polyamines and α-Carbonic Anhydrases [PDF]
Molecules, 2016 Natural products represent a straightforward source for molecular structures bearing a vast array of chemical features and potentially useful for biomedical purposes.
Andrea Scozzafava +2 more
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Transport metabolons with carbonic anhydrases [PDF]
Frontiers in Physiology, 2013 THE CONCEPT OF THE TRANSPORT METABOLON A metabolon has been defined as a “temporary, structural-functional, supramolecular complex of sequential metabolic enzymes and cellular structural elements, in which metabolites are passed from one active site to another without complete equilibration with the bulk cellular fluids” (Srere, 1985, 1987).
Joachim W Deitmer, Holger M Becker
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Inhibition studies of bacterial α-carbonic anhydrases with phenols. [PDF]
J Enzyme Inhib Med Chem, 2022 The α-class carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogens Neisseria gonorrhoeae (NgCAα) and Vibrio cholerae (VchCAα) were investigated for their inhibition by a panel of phenols and phenolic acids.
Giovannuzzi S +6 more
europepmc +2 more sources
Carbonic Anhydrases and Their Biotechnological Applications [PDF]
Biomolecules, 2013 The carbonic anhydrases (CAs) are mostly zinc-containing metalloenzymes which catalyze the reversible hydration/dehydration of carbon dioxide/bicarbonate.
Robert McKenna +3 more
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Gastric carbonic anhydrase [PDF]
The Journal of Physiology, 1939 Horace W. Davenport
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An Overview of the Bacterial Carbonic Anhydrases
Metabolites, 2017 Bacteria encode carbonic anhydrases (CAs, EC 4.2.1.1) belonging to three different genetic families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these metalloenzymes interfere with pH regulation and other crucial physiological ...
Claudiu T. Supuran, Clemente Capasso
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Carbonic anhydrases in the cell wall and plasma membrane of Arabidopsis thaliana are required for optimal plant growth on low CO2. [PDF]
Front Mol BiosciIntroduction: Plants have many genes encoding both alpha and beta type carbonic anhydrases. Arabidopsis has eight alpha type and six beta type carbonic anhydrase genes.
Weerasooriya HN +5 more
europepmc +2 more sources
An overview on the recently discovered iota-carbonic anhydrases. [PDF]
J Enzyme Inhib Med Chem, 2021 Carbonic anhydrases (CAs, EC 4.2.1.1) have been studied for decades and have been classified as a superfamily of enzymes which includes, up to date, eight gene families or classes indicated with the Greek letters α, β, γ, δ, ζ, η, θ, ι.
Nocentini A, Supuran CT, Capasso C.
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Quantitative Characterization of the Chemical Space Governed by Human Carbonic Anhydrases and selenium-containing derivatives of solfonamides [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2022 Due to the fact that different isoforms of carbonic anhydrase play distinct physiological roles, their diseases/disorders involvement are different as well.
Behnam Rasti
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AlphaFold predicts the most complex protein knot and composite protein knots [PDF]
Protein Science. 2022; 31( 8):e4380, 2022 The computer artificial intelligence system AlphaFold has recently predicted previously unknown three-dimensional structures of thousands of proteins. Focusing on the subset with high-confidence scores, we algorithmically analyze these predictions for cases where the protein backbone exhibits rare topological complexity, i.e. knotting.
arxiv +1 more source