Results 21 to 30 of about 41,221 (304)
Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors
Molecules, 2023 Sulfonamides remain an important class of drugs, especially because of their inhibitory effects on carbonic anhydrases. Herein, we have synthesized several sulfonamides and tested them for their inhibitory activity against carbonic anhydrases hCA I, hCA ...
Toni C. Denner +4 more
doaj +1 more source
Measuring kinetic parameters using quantum plasmonic sensing [PDF]
Phys. Rev. A 105, 032619 (2022), 2021 The measurement of parameters that describe kinetic processes is important in the study of molecular interactions. It enables a deeper understanding of the physical mechanisms underlying how different biological entities interact with each other, such as viruses with cells, vaccines with antibodies, or new drugs with specific diseases. In this work, we
arxiv +1 more source
Structural Basis for the Inhibition of Helicobacter pylori α-Carbonic Anhydrase by Sulfonamides. [PDF]
PLoS ONE, 2015 Periplasmic α-carbonic anhydrase of Helicobacter pylori (HpαCA), an oncogenic bacterium in the human stomach, is essential for its acclimation to low pH. It catalyses the conversion of carbon dioxide to bicarbonate using Zn(II) as the cofactor.
Joyanta K Modak +4 more
doaj +1 more source
Diverse Carbonates in Exoplanet Oceans Promote the Carbon Cycle [PDF]
Astrophys. J. Lett. 942 (2023) L20, 2023 Carbonate precipitation in oceans is essential for the carbonate-silicate cycle (inorganic carbon cycle) to maintain temperate climates. By considering the thermodynamics of carbonate chemistry, we demonstrate that the ocean pH decreases by approximately 0.5 for a factor of 10 increase in the atmospheric carbon dioxide content.
arxiv +1 more source
The immunolocalization of HIF‐2α, GLUT1 and CAIX in porcine oviduct during the estrous cycle
The Anatomical Record, Volume 306, Issue 1, Page 176-186, January 2023., 2023 Abstract Oxygen (O2) rates in the oviduct are essential to human and animal reproduction. These rates are regulated by the activity of hypoxia markers such as the hypoxia‐inducible factors (HIFs), the glucose transporters (GLUT), and the carbonic anhydrase (CA).
Ester Párraga‐Ros +4 more
wiley +1 more source
Nanomaterials, 2021 Carbonic anhydrases are enzymes capable of transforming carbon dioxide into bicarbonate to maintain functionality of biological systems. Synthetic isolation and implementation of carbonic anhydrases into membrane have recently raised hopes for emerging ...
Qian Liu +4 more
doaj +1 more source
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Combining ligand‐based and structure‐based methodologies, the applied virtual screening approach identified a collection of sulfonamides targeting the human carbonic anhydrase (hCA) VA isoform. 2‐(3,4‐Dihydro‐2H‐quinolin‐1‐yl)‐N‐(4‐sulfamoylphenyl)acetamide was identified as a potent and selective lead compound as a candidate for further exploitation ...
Laura De Luca +4 more
wiley +1 more source
Medical Sciences Forum, 2022 Carbonic anhydrases are metalloenzymes that regulate the interconversion of CO2 and H2CO3, a reaction involved in many physiological processes. A disfunction of these enzymes is known to induce many diseases such as glaucoma, epilepsy and cancer.
Yousra Ouafa Bouone +2 more
doaj +1 more source
Carbonic Anhydrases in Photosynthesizing Cells of C3 Higher Plants
Metabolites, 2019 The review presents data on the location, nature, properties, number, and expression of carbonic anhydrase genes in the photosynthesizing cells of C3 plants.
Lyudmila Ignatova +4 more
doaj +1 more source
Optimal pricing for carbon dioxide removal under inter-regional leakage [PDF]
Journal of Environmental Economics and Management 2022 102769, 2022 Carbon dioxide removal (CDR) moves atmospheric carbon to geological or land-based sinks. In a first-best setting, the optimal use of CDR is achieved by a removal subsidy that equals the optimal carbon tax and marginal damages. We derive second-best policy rules for CDR subsidies and carbon taxes when no global carbon price exists but a national ...
arxiv +1 more source