Results 21 to 30 of about 27,386 (335)
Breast Cancer Research, 2023 Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing.
Soojung Lee +13 more
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Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors
Molecules, 2023 Sulfonamides remain an important class of drugs, especially because of their inhibitory effects on carbonic anhydrases. Herein, we have synthesized several sulfonamides and tested them for their inhibitory activity against carbonic anhydrases hCA I, hCA ...
Toni C. Denner +4 more
doaj +1 more source
Carbonic anhydrases CA1 and CA4 function in atmospheric CO2-modulated disease resistance [PDF]
, 2020 Main conclusion Carbonic anhydrases CA1 and CA4 attenuate plant immunity and can contribute to altered disease resistance levels in response to changing atmospheric CO2 conditions.
Pieterse, Corné M. J. +6 more
core +2 more sources
Structural Basis for the Inhibition of Helicobacter pylori α-Carbonic Anhydrase by Sulfonamides. [PDF]
PLoS ONE, 2015 Periplasmic α-carbonic anhydrase of Helicobacter pylori (HpαCA), an oncogenic bacterium in the human stomach, is essential for its acclimation to low pH. It catalyses the conversion of carbon dioxide to bicarbonate using Zn(II) as the cofactor.
Joyanta K Modak +4 more
doaj +1 more source
Prokaryotic carbonic anhydrases [PDF]
FEMS Microbiology Reviews, 2000 Carbonic anhydrases catalyze the reversible hydration of CO(2) [CO(2)+H(2)Oright harpoon over left harpoon HCO(3)(-)+H(+)]. Since the discovery of this zinc (Zn) metalloenzyme in erythrocytes over 65 years ago, carbonic anhydrase has not only been found in virtually all mammalian tissues but is also abundant in plants and green unicellular algae.
K S, Smith, J G, Ferry
openaire +2 more sources
Nanomaterials, 2021 Carbonic anhydrases are enzymes capable of transforming carbon dioxide into bicarbonate to maintain functionality of biological systems. Synthetic isolation and implementation of carbonic anhydrases into membrane have recently raised hopes for emerging ...
Qian Liu +4 more
doaj +1 more source
Preclinical Evaluation of Ureidosulfamate Carbonic Anhydrase IX/XII Inhibitors in the Treatment of Cancers [PDF]
, 2019 Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Upregulation of the CAIX/XII isoforms is associated with hypoxic tumours and clinically linked with malignant progression, treatment ...
Gieling, Roben, Williams, Kaye J.
core +2 more sources
Medical Sciences Forum, 2022 Carbonic anhydrases are metalloenzymes that regulate the interconversion of CO2 and H2CO3, a reaction involved in many physiological processes. A disfunction of these enzymes is known to induce many diseases such as glaucoma, epilepsy and cancer.
Yousra Ouafa Bouone +2 more
doaj +1 more source
A glycosylphosphatidylinositol-anchored carbonic anhydrase-related protein of Toxoplasma gondii is important for rhoptry biogenesis and virulence [PDF]
, 2017 Carbonic anhydrase-related proteins (CARPs) have previously been described as catalytically inactive proteins closely related to α-carbonic anhydrases (α-CAs).
Beejan Asady +7 more
core +2 more sources
Carbonic Anhydrases in Photosynthesizing Cells of C3 Higher Plants
Metabolites, 2019 The review presents data on the location, nature, properties, number, and expression of carbonic anhydrase genes in the photosynthesizing cells of C3 plants.
Lyudmila Ignatova +4 more
doaj +1 more source