Results 41 to 50 of about 27,386 (335)

Chemical probing suggests redox-regulation of the carbonic anhydrase activity of mycobacterial Rv1284 [PDF]

, 2015
The mycobacterial enzyme Rv1284 is a member of the ߭carbonic anhydrase family that is considered essential for survival of the pathogen. The active site cavity of this dimeric protein is characterized by an exceptionally small volume and harbours a ...
Abas, Adams, Betts, Bhat, Bryson, Brünger, Brünger, Chim, Collaborative Computational Project Number 4, Dolinsky, Ehrt, Emsley, Gnielinski, Hofmann, Hofmann, Jones, Kabsch, Kang, Khalifah, Kimber, Kumar, Lane, McPhillips, Radchenko, Rowlett, Sassetti, Schnappinger, Schoepfer, Shiloh, Suarez Covarrubias, Suarez Covarrubias, Thakur, Tripp, Voskuil, Wang, Wang, Wang, Wayne, Zimmerman   +38 more
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Medium alkalization due to carbon metabolism is largely responsible for inhibition of bacterial growth by Vibrio cholerae supernatants [PDF]

, 2017
Vibrio cholerae is the causative agent of the diarrheal disease cholera. Many Vibrio species secrete antimicrobial factors, though the identity of such a factor has not been determined for any V. cholerae strain.
Becker, Miranda
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Carbonic Anhydrases and Metabolism

Metabolites, 2018
Although the role of carbonic anhydrases (CAs, EC 4.2.1.1) in metabolism is well-established, pharmacological applications of this phenomenon started to be considered only recently.
Claudiu T. Supuran
doaj   +1 more source

Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
A series of 6-substituted ureido- and thioureido-benzoxaboroles were investigated as inhibitors of carbonic anhydrases from Trypanosoma cruzi (TcCA), and Leishmania donovani chagasi (LdcCA). Both enzymes were inhibited by benzoxaboroles in the micromolar
Alessio Nocentini, Roberta Cadoni, Pascal Dumy, Claudiu T. Supuran, Jean-Yves Winum   +4 more
doaj   +1 more source

Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage [PDF]

, 2016
Carbonic anhydrases (CAs) III and VII are two cytosolic isoforms of the α-CA family which catalyze the physiological reaction of carbon dioxide hydration to bicarbonate and proton.
De Simone, Giuseppina, Di Fiore, Anna, Langella, Emma, Monti, Daria M, Monti, Simona M, Supuran, Claudiu T   +5 more
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Polyamines and α-Carbonic Anhydrases

Molecules, 2016
Natural products represent a straightforward source for molecular structures bearing a vast array of chemical features and potentially useful for biomedical purposes.
Andrea Scozzafava, Claudiu T. Supuran, Fabrizio Carta   +2 more
doaj   +1 more source

Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates [PDF]

, 2010
BACKGROUND: The beta-carbonic anhydrase (CA, EC 4.2.1.1) enzymes have been reported in a variety of organisms, but their existence in animals has been unclear.
Gorr, T A, Hilvo, M, Hytönen, V P, Innocenti, A, Leppiniemi, J, Niederhauser, B, Olatubosun, A, Parkkila, S, Scozzafava, A, Supuran, C T, Syrjänen, L, Tolvanen, M   +11 more
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Zinc(II)-methimazole complexes: synthesis and reactivity [PDF]

, 2015
The tetrahedral S-coordinated complex [Zn(MeImHS)(4)](ClO4)(2), synthesised from the reaction of [Zn(ClO4)(2)] with methimazole (1-methyl-3H-imidazole-2-thione, MeImHS), reacts with triethylamine to yield the homoleptic complex [Zn(MeImS)(2)] (MeImS ...
Aragoni M C, Arca M, Bettoschi A, Caltagirone C, Castellano C, Demartin F, Isaia F, Lippolis V, Pivetta T, Valletta E   +9 more
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Coral Carbonic Anhydrases: Regulation by Ocean Acidification

Marine Drugs, 2016
Global change is a major threat to the oceans, as it implies temperature increase and acidification. Ocean acidification (OA) involving decreasing pH and changes in seawater carbonate chemistry challenges the capacity of corals to form their skeletons ...
Didier Zoccola, Alessio Innocenti, Anthony Bertucci, Eric Tambutté, Claudiu T. Supuran, Sylvie Tambutté   +5 more
doaj   +1 more source

Proteomic Analysis of Chloroplast-to-Chromoplast Transition in Tomato Reveals Metabolic Shifts Coupled with Disrupted Thylakoid Biogenesis Machinery and Elevated Energy-Production Components [PDF]

, 2012
A comparative proteomic approach was performed to identify differentially expressed proteins in plastids at three stages of tomato(Solanum lycopersicum) fruit ripening (mature-green, breaker, red). Stringent curation and processing of the data from three
Alba, Aldridge, Altschul, Andersson, Andon, Armbruster, Asano, Baginsky, Balmer, Bannai, Barry, Barsan, Benjamini, Benning, Bian, Birtić, Blanke, Booth, Botella-Pavía, Bouvier, Bouyssié, Bramley, Bräutigam, Cai, Camara, Chen, Chen, Cho, Deborde, Delmar, Delmar, Demartini, Dieterle, Egea, Egea, Emanuelsson, Emes, Fan, Faurobert, Ferro, Fischer, Harris, Heazlewood, Heazlewood, Hetherington, Huang, Issaq, Jebanathirajah, Jeong, Jimenez, Kahlau, Kato, Kato, Kleffmann, Krech, Lee, Li, Li, Liu, Liu, Liu, Ljubesić, Lopez-Juez, Lundquist, Lytovchenko, Maple, Maple, Marano, McAndrew, Millar, Moing, Neta-Sharir, Niewiadomski, Onishi, Osorio, Palma, Paoletti, Pech, Peng, Pierleoni, Pirrello, Plücken, Ren, Richly, Rocco, Rutschow, Schauer, Seigneurin-Berny, Shipman-Roston, Siddique, Simkin, Small, Smith, Spurr, Su, Sun, Suzuki, Thelen, Thimm, Thomson, Tiwari, Torgrip, van Wijk, Vitha, von Zychlinski, Waters, Yakir-Tamang, Zeng, Zhang, Zhu, Zybailov   +110 more
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