Results 31 to 40 of about 3,688 (211)

Pharmacological development of target-specific delocalized lipophilic cation-functionalized carboranes for cancer therapy [PDF]

, 2016
PURPOSE: Tumor cell heterogeneity and microenvironment represent major hindering factors in the clinical setting toward achieving the desired selectivity and specificity to malignant tissues for molecularly targeted cancer therapeutics. In this study,
A Kreso, AI García-Pérez, Aikaterini Rova, AL Gartel, AR Delbridge, B Ribeiro, CC Engels, D Hanahan, D Pathania, D Theodoropoulos, DA Alcorta, Dimitrios G. Fatouros, EA Slee, ED Israels, Eirini D. Tseligka, Elsa P. Amanatiadou, F Ismail, G Calabrese, G He, Gianpiero Calabrese, Ioannis S. Vizirianakis, IS Vizirianakis, IS Vizirianakis, J Bullwinkel, J Irving, J-H Chen, JH Atkins, John Tsibouklis, JS Fridman, JS Modica-Napolitano, JS Modica-Napolitano, JS Modica-Napolitano, JT Madak, K Zhang, KF Macleod, M Kurtoglu, M Sochalska, ML Agarwal, MM Gottesman, N Parikh, P Borst, R Binet, R Galli, R Galli, R Tong, R Würth, RF Barth, S Fulda, S Haupt, S Wen, T Abbas, T Waldman, V Marcel   +52 more
core   +1 more source

Ir-catalyzed enantioselective B−H alkenylation for asymmetric synthesis of chiral-at-cage o‑carboranes

Nature Communications, 2021
Chiral-at-cage o-carboranes are clusters of carbon and boron atoms that, when functionalized, can lower the symmetry of the cluster. Here the authors present a method to alkenylate B–H bonds on ocarboranes enantioselectively via iridium catalysis.
Ruofei Cheng, Jie Zhang, Huifang Zhang, Zaozao Qiu, Zuowei Xie   +4 more
doaj   +1 more source

Carborane bis-pyridylalcohols as linkers for coordination polymers : synthesis, crystal structures and guest-framework dependent mechanical properties [PDF]

, 2017
We report the synthesis and characterization of six novel coordination polymers (CPs) based on M(II) (M: Zn and Co), di-, tri-, and tetracarboxylate linkers and two novel bis-pyridylalcohol 1,7-bis{(pyridin-n'-yl)methanol}-1,7-dicarba-closo-dodecaboranes
Choquesillo-Lazarte, Duane, Divya, Negi, Giner Planas, José, Guerrero Hernández, Miguel, Juanhuix, Judith, Maspoch Comamala, Daniel, Rodríguez-Hermida, Sabina, Sort Viñas, Jordi, Stylianou, Kyriakos C., Tan, Fangchang, Teixidor, Francesc, Verdugo-Escamilla, Cristóbal, Viñas, Clara, Ying Tsang, Min.   +13 more
core   +1 more source

Synthesis and Structure of the Bis- and Tris-Polyhedral Hybrid Carboranoclathrochelates with Functionalizing Biorelevant Substituents—The Derivatives of Propargylamine Iron(II) Clathrochelates with Terminal Triple C≡C Bond(s)

Molecules, 2021
A synthetic strategy for obtaining structurally flexible hybrid iron(II) carboranoclatrochelates functionalized with biorelevant groups, based on a combination of a 1,3-dipolar cycloaddition reaction with nucleophilic substitution of an appropriate ...
Genrikh E. Zelinskii, Ilya P. Limarev, Anna V. Vologzhanina, Valentina A. Olshevskaya, Anton V. Makarenkov, Pavel V. Dorovatovskii, Alexander S. Chuprin, Mikhail A. Vershinin, Semyon V. Dudkin, Yan Z. Voloshin   +9 more
doaj   +1 more source

Boron-containing delocalised lipophilic cations for the selective targeting of cancer cells [PDF]

, 2016
Correction for “Boron-containing delocalised lipophilic cations for the selective targeting of cancer cells” by Gianpiero Calabrese et al., Med. Chem. Commun., 2017, 8, 67–72.
Calabrese, Gianpiero, Daou, Anis, Fatouros, Dimitris, Rova, Aikaterini, Tseligka, Eirini D., Tsibouklis, John, Vizirianakis, Ioannis S   +6 more
core   +1 more source

Synthesis of Bis(Carboranyl)amides 1,1′-μ-(CH₂NH(O)C(CH₂)_n-1,2-C₂B₁₀H₁₁)₂ (n = 0, 1) and Attempt of Synthesis of Gadolinium Bis(Dicarbollide)

Molecules, 2021
Bis(carboranyl)amides 1,1′-μ-(CH2NH(O)C(CH2)n-1,2-C2B10H11)2 (n = 0, 1) were prepared by the reactions of the corresponding carboranyl acyl chlorides with ethylenediamine.
Yasunobu Asawa, Aleksandra V. Arsent’eva, Sergey A. Anufriev, Alexei A. Anisimov, Kyrill Yu. Suponitsky, Oleg A. Filippov, Hiroyuki Nakamura, Igor B. Sivaev   +7 more
doaj   +1 more source

Fabrication and Application of Isotopically Labelled Gold Arrays for Multiplexed Peptide Analysis [PDF]

, 2016
A new array-based technology for the simultaneous capture, chemical labelling and mass spectrometry analysis of peptides is presented. Isotopically labelled self-assembled monolayer (SAM) gold arrays are constructed and used simultaneously to capture and
Batalha, Buckley, Böhm, Chowdhury, Dayon, Gevaert, Gygi, Haddoub, Hudson, Kim, Laurent, Leitner, Ong, Qiu, Qui, Ross, Shi, Shi, Thompson, Valero, Washburn, Zhou, Šardzik, Šardzik   +23 more
core   +2 more sources

Carborane-Based Analog of Rev-5901 Attenuates Growth of Colon Carcinoma In Vivo

Molecules, 2022
Lipoxygenases convert polyunsaturated fatty acids into biologically active metabolites such as inflammatory mediators—prostaglandins and leukotrienes. The inhibition of lipoxygenases is increasingly employed in the treatment of cancer.
Svetlana Paskaš, Blagoje Murganić, Robert Kuhnert, Evamarie Hey-Hawkins, Sanja Mijatović, Danijela Maksimović-Ivanić   +5 more
doaj   +1 more source

Carborane–β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces [PDF]

, 2015
Supramolecular chemistry provides an attractive entry to generate dynamic and well-controlled bioactive surfaces. Novel host–guest systems are urgently needed to provide a broader affinity and applicability portfolio.
Brunsveld, Luc, Cigler, P., Jonkheijm, Pascal, Milroy, L.G., Neirynck, P., Neirynck, Pauline, Schimer, J.   +6 more
core   +5 more sources

The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications

Angewandte Chemie, EarlyView.
This work describes the synthesis of bench‐stable dicationic carboranes. Their enhanced electrophilicity is documented by opening the clusters with weak nucleophiles or dihydrogen. The surprising stability of positively charged carboranes in water enabled a study of their in vitro antiproliferative activity, which surpassed the effects of doxorubicin ...
Vlastimil Němec, Josef Holub, Maksim A. Samsonov, Zdeňka Růžičková, Josef Cvačka, Ján Vančo, Zdeněk Trávníček, Jan Belza, Zdeněk Dvořák, Jan Vrána, Aleš Růžička   +10 more
wiley   +2 more sources